LEADER 04547nam 22005775 450 001 9911049089103321 005 20260102122637.0 010 $a981-9536-28-6 024 7 $a10.1007/978-981-95-3628-3 035 $a(MiAaPQ)EBC32470092 035 $a(Au-PeEL)EBL32470092 035 $a(CKB)44768765500041 035 $a(DE-He213)978-981-95-3628-3 035 $a(EXLCZ)9944768765500041 100 $a20260102d2026 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdvancement in CAR T-Cell Therapy in Tumors $eCurrent Challenges and Future Directions /$fedited by Umesh Kumar, Anil Kumar, Deepak Parashar 205 $a1st ed. 2026. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2026. 215 $a1 online resource (474 pages) 225 1 $aBiomedical and Life Sciences Series 311 08$a981-9536-27-8 327 $aChapter 1: History and Evolution of CAR T-Cell Therapy -- Chapter 2: CAR T-Cell Therapy: Basic Principles and Mechanisms -- Chapter 3: Engineering CAR T-Cells: Advances in Vector Design and Gene Editing -- Chapter 4: Optimizing CAR T-Cell Efficacy: Enhancing Proliferation, Persistence, and Memory -- Chapter 5: Clinical Success of CAR T-Cells in Hematologic Cancers: Lessons from Leukemia and Lymphoma -- Chapter 6: Adverse Effects of CAR T-Cell Therapy and Management: Cytokine Release Syndrome and Neurotoxicity -- Chapter 7: Overcoming Challenges of CAR T-Cell Therapy in Solid Tumor Microenvironments -- Chapter 8: From Bench to Bedside: Innovations and Challenges in CAR-T Cell Therapy Manufacturing and Regulation -- Chapter 9: Combining CAR T Cells with Immunotherapies to Enhance Treatment Effectiveness -- Chapter 10: Next-Generation CARs and Beyond: Synthetic Biology and Logic-Gated in Next-Generation CARs -- Chapter 11: Regulatory landscape and challenges in CAR-T cell therapy development and clinical trials -- Chapter 12: Personalized CAR T-Cell Therapy: Tailoring to Patient-Specific Tumors. 330 $aThis contributed volume provides a comprehensive overview of CAR T-cell therapy, focusing on its application in solid tumors, an area where treatment success has been more elusive. While CAR T-cell therapy has revolutionized the treatment of hematologic malignancies, its potential in solid tumors remains a frontier of intense research and development. This volume bridges the knowledge gap by addressing both the successes and challenges faced by researchers and clinicians in this evolving field. The chapters cover topics such as the design of next-generation CAR T-cells, novel targets for solid tumors, and the integration of CAR T-cell therapy with other immunotherapeutic strategies. Readers will discover cutting-edge techniques like CRISPR-mediated gene editing, bispecific CARs, and synthetic biology. The book also explores critical questions about manufacturing challenges, regulatory hurdles, and clinical trial outcomes, providing a holistic view of CAR T-cell therapy. Contributions from leading experts in oncology, immunology, and molecular biology offer a multidisciplinary perspective, making this book a valuable resource for understanding the molecular and clinical dynamics of CAR T-cell therapy. This book is designed for a diverse audience, including researchers, clinicians, and industry professionals involved in cancer research, immunotherapy, and clinical applications. It is also a key reference for graduate and postgraduate students in fields like oncology, immunology, and biotechnology. By offering a comprehensive analysis of the technical, clinical, and regulatory aspects of CAR T-cell therapy, this book serves as a critical resource in the advancement of cancer treatment. 410 0$aBiomedical and Life Sciences Series 606 $aTumors$xImmunological aspects 606 $aCancer$xTreatment 606 $aCancer 606 $aTumour Immunology 606 $aCancer Therapy 606 $aCancer Biology 615 0$aTumors$xImmunological aspects. 615 0$aCancer$xTreatment. 615 0$aCancer. 615 14$aTumour Immunology. 615 24$aCancer Therapy. 615 24$aCancer Biology. 676 $a571.96 676 $a616.99 700 $aKumar$b Umesh$01886520 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911049089103321 996 $aAdvancement in CAR T-Cell Therapy in Tumors$94522063 997 $aUNINA