LEADER 03697nam  22005895  450 
001 9911040909703321
005 20251110124915.0
010   $a3-032-04125-2
024 7 $a10.1007/978-3-032-04125-8
035   $a(MiAaPQ)EBC32407107
035   $a(Au-PeEL)EBL32407107
035   $a(CKB)42574844800041
035   $a(DE-He213)978-3-032-04125-8
035   $a(EXLCZ)9942574844800041
100   $a20251110d2025      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aTransposable Elements, Transcriptomics, and Diseases /$fedited by Luis M. Vaschetto
205   $a1st ed. 2025.
210  1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025.
215   $a1 online resource (631 pages)
225 1 $aEpigenetics and Human Health,$x2191-2270 ;$v14
311 08$a3-032-04124-4 
327   $aChapter 1. Transposable Elements and Genome Evolution in Vertebrates -- Chapter 2. Transposable Elements and Gene Duplication -- Chapter 3. Transposable Elements and their Roles in Genome Architecture -- Chapter 4. Epigenetic Control of Transposable Elements -- Chapter 5. Transposable Element-Derived Non-coding RNAs -- Chapter 6. Transposable Elements: The Role of the piRNA Pathway -- Chapter 7. The Role of Transposable Elements in Development -- Chapter 8. The Impact of Transposable Elements on Immune Pathways -- Chapter 9. Transposable Elements and Hereditary Diseases -- Chapter 10. Transposable Elements in Cancer -- Chapter 11. Transposable Elements as Drivers of Age-Related Neurodegenerative Disease -- Chapter 12. Retrotransposons: Silent Architects of Vascular Aging and Disease -- Chapter 13. The Role of Transposable Elements in Therapeutics.
330   $aTransposable elements (TEs) are mobile DNA sequences once referred to as "selfish DNA". While they have contributed significantly to genome evolution, their movement can often disrupt genes and lead to disease. To counteract this, organisms have developed post-transcriptional, transcriptional, and epigenetic mechanisms to control TE activity. This book explores the complex interplay between mobile genetic elements and human health, providing a comprehensive overview of TE biology, their modes of action, and the strategies employed to suppress their movement, and offering valuable insights into potential therapeutic interventions targeting TE-related diseases. In particular, the book reviews how TEs affect gene expression and contribute to diseases such as cancer, neurodegenerative diseases, and inherited disorders. Other topics include TE polymorphisms, epigenetic control, co-opted functions, non-coding RNAs, and their roles in environmental stress and immune pathways. Providing a comprehensive reference on the subject, this book is intended for researchers and advanced students in genetics and related disciplines. .
410  0$aEpigenetics and Human Health,$x2191-2270 ;$v14
606   $aEpigenetics
606   $aMedical genetics
606   $aCytology
606   $aDiseases
606   $aEpigenetics
606   $aMedical Genetics
606   $aMechanisms of Disease
615  0$aEpigenetics.
615  0$aMedical genetics.
615  0$aCytology.
615  0$aDiseases.
615 14$aEpigenetics.
615 24$aMedical Genetics.
615 24$aMechanisms of Disease.
676   $a572.865
700   $aVaschetto$b Luis M$01740613
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9911040909703321
996   $aTransposable Elements, Transcriptomics, and Diseases$94456079
997   $aUNINA