LEADER 01241nam a2200289 i 4500 001 991000675899707536 005 20020503194517.0 008 990416s1997 it ||| | ita 020 $a8814064237 035 $ab10112686-39ule_inst 035 $aLE02520236$9ExL 040 $aFac. Economia$bita 082 0 $a368.32 100 1 $aBazzano, Claudio$0117492 245 13$aLa previdenza complementare e integrativa :$bdal 1. al 4. pilastro :$bi fondi pensione, i fondi aperti, l'assicurazione sulla vita, i fondi comuni di investimento, le prestazioni dell'Inps; aspetti tecnici, fiscali e giuridici, esemplificazioni pratiche /$cClaudio Bazzano 260 $aMilano :$bGiuffrè,$cc1997 300 $axiv, 347 p. ;$c24 cm. 490 0 $aCosa & come. Lavoro e previdenza [Giuffrè] 650 4$aAssicurazioni vita 650 4$aFondi comuni di investimento mobiliare 650 4$aFondi pensione 907 $a.b10112686$b17-02-17$c27-06-02 912 $a991000675899707536 945 $aLE025 ECO 368 BAZ01.01$g1$i2025000059030$lle025$o-$pE0.00$q-$rl$s- $t0$u26$v22$w26$x0$y.i10131735$z27-06-02 996 $aPrevidenza complementare e integrativa$9198098 997 $aUNISALENTO 998 $ale025$b01-01-99$cm$da $e-$fita$git $h3$i1 LEADER 05344nam 22006615 450 001 9911034962703321 005 20251020130418.0 010 $a3-031-92526-2 024 7 $a10.1007/978-3-031-92526-9 035 $a(MiAaPQ)EBC32364864 035 $a(Au-PeEL)EBL32364864 035 $a(CKB)41689377100041 035 $a(DE-He213)978-3-031-92526-9 035 $a(EXLCZ)9941689377100041 100 $a20251020d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCerebrotendinous Xanthomatosis $eA Treatable Rare Neurometabolic Disorder /$fedited by Antonio Federico, Andrea E. DeBarber, Tzipora C. Falik-Zaccai, Hidde H. Huidekoper, Robert D. Steiner 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (458 pages) 225 1 $aMedicine Series 311 08$a3-031-92525-4 327 $a1. Cerebrotendinous Xantomatosis (CTX): general review and history of the research on its pathogenesis and therapy -- 2. CerebroTendinous Xanthomatosis (CTX) in Italy -- 3. CTX in The Netherlands -- 4. CTX in Brazil -- 5. Cerebrotendinous xanthomatosis in France -- 6.CTX in Japan -- 7. Cerebrotendinous Xanthomatosis: remaining challenges and the need for international collaboration -- 8. Genetics of CTX -- 9. General Overview Biochemistry with Focus on Clinical Laboratory -- 10. Focus on CTX Cases Identified with Atypical Biochemistry -- 11.Cholestanol accumulation in the brain and eye in cerebrotendinous xanthomatosis -- 12. Role of Bile Acid Pathway Intermediates in Pathology of CTX -- 13. Overview of Neuroimaging in Cerebrotendinous Xanthomatosis Diagnosis -- 14. Novel tools for neuroimaging in cerebrotendinous xanthomatosis -- 15. Epidemiology of Cerebrotendinous Xanthomatosis -- 16. Chenodeoxycholic acid treatment in the italian cohort of CTX patients -- 17. Long-term treatment effect in CTX depends on age at treatment -- 18.Can we improve outcomes? Lessons taken from the Israeli CTX Cohort -- 19. Treatment during Pregnancy in CTX -- 20. Cerebrotendinous xanthomatosis (CTX) presenting as neonatal cholestasis, its diagnosis and treatment with primary bile acids, cholic and chenodeoxycholic acids -- 21. Cholic acid treatment in adults with cerebrotendinous xanthomatosis -- 22. Gene Therapy for CTX -- 23. CTX Pediatric presentation -- 24. Ophthalmic manifestation in CTX -- 25. Update on Newborn Screening for Cerebrotendinous Xanthomatosis -- 26. Early treatment improves outcomes for patients with cerebrotendinous xanthomatosis (CTX) -- 27. Cerebrotendinous Xanthomatosis Patient and Family Opinions and International CTX Patient Advocacy. 330 $aThis book represents an update on the clinical, biochemical and molecular genetic findings of a rare neurometabolic disorder. Cerebrotendinous xanthomatosis (CTX), first described in 1937, is a rare genetic disorder of bile acid synthesis that can cause developmental and cognitive disability, irreversible neurological damage and premature death. Left untreated, the syndrome is slowly progressive but can now be considered a treatable rare neurologic disease of lipid and bile metabolism. Early identification of this disorder, for example with newborn screening, would be highly significant as the burden of disease if left untreated can be profound, and morbidity and mortality easily prevented through early detection and treatment. The book collects the experience of expert physician-scientists and researchers from all over the world, beginning with the history of the disease and providing updates on the new molecular genetic data, the therapies and the international patient advocacy organizations, also with chapters reporting the experiences of the patients and calling for improved international basic research and clinical collaboration, aiming to advance understanding and enhance outcomes for CTX patients and their families, and foster patient group partnerships. The volume stems from the proceedings of an international meeting held in Jerusalem, Israel, where this disease was investigated for many years by a pioneer in the field, Prof. Vladimir Berginer at the Ben-Gurion University of the Negev. This meeting was hosted by the CTX Alliance, a patient advocacy group based in the USA. 410 0$aMedicine Series 606 $aNeurology 606 $aPediatrics 606 $aMedical genetics 606 $aInternal medicine 606 $aNeurology 606 $aPediatrics 606 $aClinical Genetics 606 $aInternal Medicine 615 0$aNeurology. 615 0$aPediatrics. 615 0$aMedical genetics. 615 0$aInternal medicine. 615 14$aNeurology. 615 24$aPediatrics. 615 24$aClinical Genetics. 615 24$aInternal Medicine. 676 $a616.39 700 $aFederico$b Antonio$0343850 701 $aDeBarber$b Andrea E$01852727 701 $aFalik-Zaccai$b Tzipora C$01852728 701 $aHuidekoper$b Hidde H$01852729 701 $aSteiner$b Robert D$018807 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911034962703321 996 $aCerebrotendinous Xanthomatosis$94448611 997 $aUNINA