LEADER 02534nam 2200457z- 450 001 9910557223103321 005 20211118 035 $a(CKB)5400000000041713 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/73676 035 $a(oapen)doab73676 035 $a(EXLCZ)995400000000041713 100 $a20202111d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aApplying Next Generation Sequencing and Transgenic Models to Rare Disease Research 210 $cFrontiers Media SA$d2020 215 $a1 online resource (119 p.) 311 08$a2-88963-524-4 330 $aA rare disease is a disease that occurs infrequently in the general population, typically affecting fewer than 200,000 Americans at any given time. More than 30 million people in the United States of America (USA) and 350 million people globally suffer from rare diseases. Out of the 7000+ known rare diseases, less than 5% have approved treatments. Rare diseases are frequently chronic, progressive, degenerative, and life-threatening, compromising the lives of patients by loss of autonomy. In the USA, it can take years for a rare disease patient to receive a correct diagnosis. The socioeconomic burden for rare disease is huge. For those living with diagnosed rare diseases, there is no support system or resource bank for navigating financial, educational, or other aspects of having a rare disease. The purpose of this Research Topic is to bring together leading researchers, non-profit organizations, healthcare providers/diagnostic companies, and pharma/biotech/CROs in the field to provide a broad perspective on the latest advances, challenges, and opportunities in rare disease research. 606 $aMedical genetics$2bicssc 606 $aScience: general issues$2bicssc 610 $agenetic analysis 610 $aGenomics 610 $aNext generation sequencing 610 $aRare disease 610 $atransgenic 615 7$aMedical genetics 615 7$aScience: general issues 700 $aGouw$b Arvin M$4edt$01317941 702 $aJaishankar$b Amritha$4edt 702 $aBrooks$b George A$4edt 702 $aGouw$b Arvin M$4oth 702 $aJaishankar$b Amritha$4oth 702 $aBrooks$b George A$4oth 906 $aBOOK 912 $a9910557223103321 996 $aApplying Next Generation Sequencing and Transgenic Models to Rare Disease Research$93033116 997 $aUNINA LEADER 03333nam 22005775 450 001 9911034859503321 005 20251030133401.0 010 $a3-032-02721-7 024 7 $a10.1007/978-3-032-02721-4 035 $a(MiAaPQ)EBC32352795 035 $a(Au-PeEL)EBL32352795 035 $a(CKB)41645656400041 035 $a(OCoLC)1545538540 035 $a(DE-He213)978-3-032-02721-4 035 $a(EXLCZ)9941645656400041 100 $a20251015d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Multifacetedness of Reasonableness in Legal and in Political Theory /$fby Michele Mangini 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (313 pages) 225 1 $aPhilosophy and Politics - Critical Explorations,$x2352-8389 ;$v32 311 08$a3-032-02720-9 327 $aChapter 1. Social Psychology Theories, Unity of Virtues and Reasonableness -- Chapter 2. Human Flourishing: Between Epistemic and Ethical Reasonableness -- Chapter 3. Toward a Theory of Reasonableness -- Chapter 4. Is the Reasonable Person a Person of Virtue? -- Chapter 5. Ethics of Virtues and the Education of the Reasonable Judge -- Chapter 6. Continuity Between Ethics and Politics in EU Citizenship. The Model of the Reasonable Citizen -- Chapter 7. Taking Populism Seriously: A Conservative Ethos for Liberal Democracy? -- Chapter 8. Liberal Perfectionism and the Virtues -- Chapter 9. Environmental Virtue Ethics According to Reasonableness. 330 $aThis book offers a complete overview of the complex topic of reasonableness. Ranging through ethics, political theory and legal theory, the author shows how ?reasonable? is an unescapable evaluative term. One uses this concept to evaluate positively or negatively ? ?it is unreasonable!? ? both our conduct and that of others. However, we are often not aware of the presuppositions behind our use of the concept. Especially the legal use, both in civil and in common law, reveals a large variety of meanings and the so called ?multifacetedness? of reasonableness. In an age in which the environmental crisis or ?global climate change? threatens our style of life we badly need criteria of evaluation that we all can share. This book therefore provides a unitary conception that connects to the ethics of virtues as the fabric that links the many uses of ?the reasonable?. 410 0$aPhilosophy and Politics - Critical Explorations,$x2352-8389 ;$v32 606 $aPolitical science$xPhilosophy 606 $aPolitical science 606 $aPhilosophy 606 $aPolitical Philosophy 606 $aPolitical Theory 606 $aPhilosophy 615 0$aPolitical science$xPhilosophy. 615 0$aPolitical science. 615 0$aPhilosophy. 615 14$aPolitical Philosophy. 615 24$aPolitical Theory. 615 24$aPhilosophy. 676 $a320.01 700 $aMangini$b Michele$0323833 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911034859503321 996 $aThe Multifacetedness of Reasonableness in Legal and in Political Theory$94450891 997 $aUNINA