LEADER 03602nam 2200733Ia 450 001 9911101047603321 005 20251017110117.0 010 $a9786611109905 010 $a9780309178891 010 $a0309178894 010 $a9781281109903 010 $a1281109908 010 $a9780309112994 010 $a0309112990 035 $a(CKB)1000000000481354 035 $a(OCoLC)290499734 035 $a(CaPaEBR)ebrary10201098 035 $a(SSID)ssj0000104639 035 $a(PQKBManifestationID)11127846 035 $a(PQKBTitleCode)TC0000104639 035 $a(PQKBWorkID)10080192 035 $a(PQKB)10874639 035 $a(MiAaPQ)EBC3564131 035 $a(Au-PeEL)EBL3564131 035 $a(CaPaEBR)ebr10201098 035 $a(CaONFJC)MIL110990 035 $a(OCoLC)932320413 035 $a(Perlego)4736484 035 $a(DNLM)1464987 035 $a(BIP)14742161 035 $a(EXLCZ)991000000000481354 100 $a20080102d2007 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aApplications of toxicogenomic technologies to predictive toxicology and risk assessment /$fCommittee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$dc2007 215 $a1 online resource (299 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a9780309112987 311 08$a0309112982 320 $aIncludes bibliographical references. 327 $aIntroduction -- Toxicogenomic technologies -- Experimental design and data analysis -- Application to exposure assessment -- Application to hazard screening -- Application to analyzing variation in human susceptibility -- Application to the study of mechanisms of action -- Other potential applications of toxicogenomic technologies to risk assessment -- Validation -- Sample and data collection and analysis -- Ethical, legal, and social issues -- Conculsions and recommendations. 330 $aThe new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new ways--an effort requiring funding, interagency coordination, and data management strategies. 606 $aGenetic toxicology 606 $aDNA microarrays$xStatistical methods 606 $aHealth risk assessment 606 $aCarcinogenesis 615 0$aGenetic toxicology. 615 0$aDNA microarrays$xStatistical methods. 615 0$aHealth risk assessment. 615 0$aCarcinogenesis. 676 $a616/.042 712 02$aNational Academies Press (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911101047603321 996 $aApplications of toxicogenomic technologies to predictive toxicology and risk assessment$94753865 997 $aUNINA LEADER 01756nam 2200433zu 450 001 9911034575203321 005 20251027170509.0 010 $a1-60606-953-5 035 $a(CKB)41693464500041 035 $a(EXLCZ)9941693464500041 100 $a20251023|2025uuuu || | 101 0 $aeng 135 $aur||||||||||| 200 00$aEd Ruscha's Streets of Los Angeles $eartist, image, archive, city /$fedited by Andrew Perchuk, Emily Pugh, and Zanna Gilbert, with Tracy Stuber and Isabel Frampton Wade 210 $cGetty Publications$d2025 311 08$a1-60606-952-7 330 $a"Through analysis of Ed Ruscha's visionary Streets of Los Angeles Archive, this volume provides new understandings of Ruscha's artistic practice, the history of L.A., and the innovative role of technology in the archive"--$cProvided by publisher. 606 $aStreet photography$zCalifornia$zLos Angeles 606 $aArchitectural photography$zCalifornia$zLos Angeles 606 $aDocumentary photography$zCalifornia$zLos Angeles 606 $aRepeat photography$zCalifornia$zLos Angeles 606 $aPhotography$xArchive applications 606 $aArchives$xProcessing 607 $aLos Angeles (Calif.)$xHistory$y20th century 615 0$aStreet photography 615 0$aArchitectural photography 615 0$aDocumentary photography 615 0$aRepeat photography 615 0$aPhotography$xArchive applications. 615 0$aArchives$xProcessing. 676 $a779/.9979494 702 $aPerchuk$b Andrew 702 $aPugh$b Emily 702 $aGilbert$b Zanna$f1980- 712 02$aGetty Research Institute, 906 $aBOOK 912 $a9911034575203321 996 $aEd Ruscha's Streets of Los Angeles$94795120 997 $aUNINA LEADER 11996oam 22005773 450 001 9911133052503321 005 20260605202343.0 010 $a9781118272114$b(electronic bk.) 035 $a(MiAaPQ)EBC1372259 035 $a(Au-PeEL)EBL1372259 035 $a(CaPaEBR)ebr10748680 035 $a(CaONFJC)MIL511740 035 $a(OCoLC)859161266 035 $a(MiAaPQ)EBC7103473 035 $a(CKB)17684668000041 035 $a(FR-PaCSA)88838967 035 $a(FRCYB88838967)88838967 035 $a(EXLCZ)9917684668000041 100 $a20220831d2013 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aClinical Biochemistry 205 $a9th ed. 210 1$aNew York :$cJohn Wiley & Sons, Incorporated,$d2013. 210 4$d©2014. 215 $a1 online resource (304 pages) 225 1 $aLecture Notes Ser. 311 08$aPrint version: Walker, Simon W. Clinical Biochemistry New York : John Wiley & Sons, Incorporated,c2013 9781118272138 327 $aIntro -- Clinical Biochemistry: Lecture Notes -- Contents -- Preface -- List of abbreviations -- How to use your textbook -- About the companion website -- 1 Requesting and interpreting tests -- Introduction -- Collection of specimens -- The use of clinical biochemistry tests -- Point of care testing (POCT) (Table 1.5) -- Interpretation of clinical biochemistry tests -- Sources of variation intest results -- Analytical sources of variation -- Blunders -- Biological causes of variation -- How do results vary in health? -- How do results vary in disease? -- The assessment of diagnostic tests -- Audit in clinical biochemistry -- The audit process -- FURTHER READING -- Appendix 1.1: Screening for rare diseases -- 2 Disturbances of water, sodium and potassium balance -- Introduction -- Water and sodium balance -- Internal distribution of water and sodium -- Osmolality and tonicity -- Colloid osmotic pressure (oncotic pressure -- Regulation of external water balance -- Regulation of external sodium balance -- Disorders of water and sodium homeostasis -- Hyponatraemia -- Hypernatraemia -- Other chemical investigations influid balance disorders -- Blood specimens -- Urine specimens -- Potassium balance -- Abnormalities of plasma potassium concentration -- Hypokalaemia -- Hyperkalaemia -- Other investigations in disordered K+ metabolism -- Fluid and electrolyte balance in surgical patients -- Intravenous fluid administration -- FURTHER READING -- 3 Acid-base balance and oxygen transport -- Introduction -- Transport of carbondioxide -- Renal mechanisms for HCO3 reabsorption and H+ excretion -- Buffering of hydrogen ions -- Investigating acid-base balance -- Collection and transport of specimens -- Temperature effects -- Disturbances of acid-base status -- Respiratory acidosis -- Respiratory alkalosis -- Metabolic acidosis -- Metabolic alkalosis. 327 $aInterpretation of results of acid-base assessment -- Plasma [H+] is increased -- Plasma [H+] is decreased -- Plasma [H+] is normal -- Mixed acid-base disturbances -- Other investigations in acid-base assessment -- Total CO2 (reference range 24-30 mmol/L) -- Anion gap (reference range 10-20 mmol/L) -- Plasma chloride (reference range 95-107 mmol/L) -- Treatment of acid-base disturbances -- Oxygen transport -- Indications for full blood acid-base and oxygen measurements -- Respiratory insufficiency -- Type I: low PO2 with normal or low PCO2 -- Type II: low PO2 with high PCO2 -- Oxygen therapy -- FURTHER READING -- 4 Renal disease -- Introduction -- Impaired renal function -- Tests of glomerular function -- Measurement of creatinine clearance -- Estimation of creatinine clearance -- Plasma creatinine -- Creatinine clearance or plasma [creatinine]? -- Low plasma [creatinine] -- High plasma [creatinine] -- Plasma urea -- Tests of tubular function -- Urine osmolality and renal concentration tests -- Fluid deprivation test -- DDAVP test -- Urinary acidification tests -- Renal tubular acidosis -- Glycosuria -- The amino acidurias -- Fanconi syndrome -- Renal handling of sodium and potassium -- Sodium excretion -- Potassium excretion -- Acute kidney injury -- Chronic kidney disease -- Proteinuria -- Overflow proteinuria -- Glomerular proteinuria -- Nephrotic syndrome -- Glomerulonephritis -- Orthostatic proteinuria -- Tubular proteinuria -- Renal stones -- Hypercalciuria -- Oxalate, cystine and xanthine excretion -- Chemical investigations on patients with renal stones -- FURTHER READING -- 5 Disorders of calcium, phosphate and magnesium metabolism -- Calcium homeostasis -- Calcium balance -- Biological function of calcium -- Control of calcium metabolism -- Investigation of abnormal calcium metabolism -- Hypercalcaemia -- Primary hyperparathyroidism. 327 $aHypercalcaemia of malignancy -- Other causes of hypercalcaemia -- Hypocalcaemia -- Vitamin D deficiency -- Hypoparathyroidism -- Metabolic bone disease -- Markers of bone turnover -- Rickets and osteomalacia -- Osteoporosis -- Paget's disease -- Renal osteodystrophy -- Phosphate metabolism -- Hypo- and hyperphosphataemia -- Magnesium metabolism -- Hypomagnesaemia and magnesium deficiency -- Hypermagnesaemia -- 6 Diabetes mellitus and hypoglycaemia -- Glucose homeostasis -- Insulin secretion -- Diabetes mellitus -- Diagnosis -- Blood and plasma glucose -- Oral glucose tolerance test (OGTT) -- Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) -- Monitoring the treatment of diabetic patients -- Home blood glucose monitoring -- Glycated haemoglobin -- Glycated plasma proteins -- Microalbumin -- Metabolic complications of diabetes mellitus -- Diabetic ketoacidosis (DKA) -- Laboratory assessment and management of diabetic ketoacidosis -- Nonketotic, hyperglycaemic coma -- Hypoglycaemia -- Fasting hypoglycaemia -- Reactive or postprandial hypoglycaemia -- Insulinoma -- Other causes of fasting hypoglycaemia -- FURTHER READING -- 7 Disorders of the hypothalamus and pituitary -- Introduction -- The hypothalamus -- Anterior pituitary hormones -- Corticotrophin-releasing hormone and adrenocorticotrophic hormone -- Gonadotrophin-releasing hormone and the gonadotrophins luteinising hormone and follicle-stimulating hormone -- Thyrotrophin-releasing hormone and thyroid-stimulating hormone -- Growth hormone-releasing hormone and growth hormone -- Acromegaly and gigantism -- Prolactin -- Hyperprolactinaemia and its investigation -- Hyperprolactinaemia in psychiatric patients -- Endocrine changes in anorexia nervosa -- Anterior pituitary disease and its investigation -- Causes -- Investigation -- Treatment. 327 $aDynamic function tests - insulin stress test -- Monitoring treatment in hypopituitarism -- Monitoring hormone replacement therapy -- Posterior pituitary hormones -- Vasopressin -- 8 Abnormalities of thyroid function -- Introduction -- Thyroid hormone synthesis, action and metabolism -- Synthesis and metabolism -- Plasma transport and cellular action -- Regulation of thyroid function -- Investigations to determine thyroid status -- Selective use of thyroid function tests -- Interpreting results of thyroid function tests -- Hyperthyroidism -- Hypothyroidism -- T4 replacement therapy -- T4 replacement in subclinical hypothyroidism -- T4 therapy in central hypothyroidism (hypopituitarism) -- Situations in which thyroid function test results may be misleading -- Thyroid hormone resistance (THR) -- Causes of abnormal results for thyroid hormone measurements in euthyroid subjects -- Miscellaneous chemical tests and thyroid disease -- TRH test -- Anti-thyroid peroxidase antibodies (TPOAbs) -- Thyrotrophin receptor antibodies (TRAbs) -- Tests affected by thyroid dysfunction -- 9 Disorders of the adrenal cortex and medulla -- Introduction -- Regulation of adrenal steroid hormone synthesis and secretion -- Glucocorticoid secretion -- Aldosterone secretion -- Androgen secretion -- Investigation of suspected adrenocortical hyperfunction -- Cushing's syndrome -- Tests used to establish if a clinical diagnosis of Cushing's syndrome is likely -- Treatment -- Investigation of suspected adrenocortical hypofunction -- Diagnosis of primary adrenal hypofunction (Addison's disease) -- Diagnosis of secondary adrenocortical insufficiency -- Other pituitary function tests -- Biochemical tests in the investigation of hypertension -- Secondary hypertension -- Primary hyperaldosteronism (low-renin hyperaldosteronism) -- Investigation of suspected primary hyperaldosteronism. 327 $aSecondary hyperaldosteronism (high-renin hyperaldosteronism) -- Mineralocorticoid deficiency -- Inherited adrenocortical enzyme defects -- Phaeochromocytoma -- Diagnosis -- Urine fractionated metadrenalines -- 10 Investigation of gonadal function infertility, menstrual irregularities and hirsutism -- Introduction -- Male gonadal function -- Spermatogenesis and its control -- Transport, metabolism and actions of testosterone -- Investigation of infertility and male hypogonadism -- Hypergonadotrophic and hypogonadotrophic hypogonadism -- Female gonadal function -- Menstrual disorders and infertility -- Ovarian dysfunction and its investigation -- Oligomenorrhoea and amenorrhoea -- Infertility -- Hirsutism and virilism -- Polycystic ovarian syndrome (PCOS) -- Ovarian failure -- Hormone replacement therapy -- Steroid contraceptives -- 11 Pregnancy and antenatal screening -- Introduction -- The foetoplacental unit -- Human chorionic gonadotrophin -- Steroids in pregnancy -- Effect of pregnancy on biochemical tests -- Reproductive hormones -- Cortisol -- Thyroid function tests -- Plasma volume and renal function -- Serum lipids and proteins -- Liver function tests -- Iron and ferritin -- Complications in pregnancy -- Ectopic pregnancy -- Diabetes mellitus -- Thyroid disorders -- Pre-eclampsia -- Obstetric cholestasis -- Pre-natal diagnosis of foetal abnormalities -- Screening for trisomy 21 -- Neural tube defects -- 12 Cardiovascular disorders -- The diagnosis of myocardial infarction -- Biochemical tests in myocardial infarction and ischaemia -- Time-course of changes -- Optimal times for blood sampling -- Creatine kinase -- The diagnosis of heart failure -- The diagnosis of thromboembolic disease -- Cardiovascular risk factors -- Lipids -- Enzymes involved in lipid transport -- Metabolism of plasma lipoproteins -- Chylomicron metabolism. 327 $aVLDL and IDL metabolism. 330 $aConcise yet comprehensive, Clinical Biochemistry Lecture Notes contains all the essential information for students and foundation doctors to understand the biochemical basis of disease and principles of biochemical diagnostics. It presents scientific principles in a clinical setting, with a range of case studies integrated into the text to clearly demonstrate how knowledge should be applied to real-life situations. Key features include:  The fundamental science underpinning common biochemical disorders and their investigation in clinical practice  Accessible flow charts of biochemical processes and the reasoning behind specific tests, making look-up and understanding easy  A brand new companion website at www.lecturenoteseries.com/clinicalbiochemistry with self-assessment and downloadable summary slides for revision Clinical Biochemistry Lecture Notes is an ideal overview and revision guide for medical students, foundation doctors, general practitioners, and nurses. It also provides a core text for scientific and medical staff pursuing a career in clinical biochemistry. 410 0$aLecture Notes Ser. 606 $aBiochemical Phenomena 615 0$aBiochemical Phenomena. 676 $a616.07/56 700 $aWalker$b Simon W 701 $aBeckett$b Geoffrey J 701 $aRae$b Peter 701 $aAshby$b Peter 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9911133052503321 997 $aUNINA