LEADER 00919nam a2200229 i 4500 001 991003068179707536 005 20021122115143.0 008 021001s2001 it ||| | ita 035 $ab11750030-39ule_inst 035 $aLE00646028$9ExL 040 $aDip.to Fisica$bita 100 1 $aCucinelli, Rosanna$0530277 245 12$aL'acqua su Marte :$bpassato e presente. Tesi di laurea /$claureanda Rosanna Cucinelli ; relatore Sergio Fonti 260 $aLecce :$bUniversità degli Studi, Lecce. Facoltà di Scienze. Corso di laurea in Fisica,$ca.a. 2000-01 300 $a110 p. :$bill. ;$c30 cm. 700 1 $aFonti, Sergio 907 $a.b11750030$b02-04-14$c22-11-02 912 $a991003068179707536 945 $aLE006 T724$g1$i2006000087346$lle006$o-$pE0.00$q-$rn$so $t0$u0$v0$w0$x0$y.i11992554$z22-11-02 996 $aAcqua su Marte$9905537 997 $aUNISALENTO 998 $ale006$b01-01-02$cm$da $e-$fita$git $h2$i1 LEADER 03946nam 22005415 450 001 9911021142303321 005 20250814124701.0 010 $a981-9678-90-0 024 7 $a10.1007/978-981-96-7890-7 035 $a(MiAaPQ)EBC32263292 035 $a(Au-PeEL)EBL32263292 035 $a(CKB)40336142600041 035 $a(DE-He213)978-981-96-7890-7 035 $a(EXLCZ)9940336142600041 100 $a20250814d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Biological Role of Small Leucine-Rich Proteoglycans (SLRPs) in Matrix Homeostasis and Diseases /$fedited by Polly Lama 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (288 pages) 311 08$a981-9678-89-7 327 $aCh 1 The family, structure, and functions of small leucine rich proteoglycans (SLRPs).-Ch 2 Diseases of the matrix and the role of SLRPs in inflammatory catabolism -- Ch 3 Regulatory role and significance of class I SLRPs: Biglycan, Decorin and Asporin -- Ch 4 Regulatory role and significance of Class II SLRP?s: Fibromodulin, Lumican, Osteoadherin, PRELP, and keratocan -- Ch 5 Regulatory role and significance of Class III SLRPs: Osteoglycin, Epiphycan and Opticin -- Ch 6 Regulatory role and significance of Class IV SLRPs: Tsukushi, Chondroadherin and Nyctalopin -- Ch 7 Regulatory role and significance of Class V SLRPs: Podocan and Podocan-like protein-1 -- Ch 8 Biological basis behind molecular fragmentation of SLRPs as DAMPs -- Ch 9 SLRPs and its therapeutic relevance -- Ch 10: Critical conclusive overview: SLRPs as DAMPs. 330 $aThis book covers advanced and up-to-date analyses of the synthesis, fragmentation, and dysregulation of Small Leucine-Rich Proteoglycans (SLRPs) in some common matrix-related diseases. These SLRPs act as autonomous triggers of inflammation in conditions such as cancer, cartilage tissue degeneration, renal (kidney) diseases, as well as skin, tendon, musculoskeletal, and craniofacial tissues, responding to stress, injury, and impairment of normal function. Chapters describe the significance behind the formation of proteolytic molecular fragments of SLRPs and why they alter inflammatory cell-signaling pathways, acting as Damage-Associated Molecular Patterns (DAMPs), that can function as Pathogen-Associated Molecular Patterns (PAMPs) in the early, intermediate, and advanced stages of matrix dysregulation and diseases. It also discusses evidence-based therapeutic approaches useful for identifying molecular fragments as potential biomarkers of matrix degeneration, providing a thorough understanding on the regulatory role of SLRPs in matrix homeostasis and diseases. The book is supplemented with well-illustrated figures, tabulated analysis, and critical review questions for further investigations that identifies gap in current understanding. The book is relevant for experts in medical sciences specializing in cell, extracellular matrix-based tissue analysis, researchers, as well as students interested in investigating matrix-related changes during the pathological progression of diseases. 606 $aCytology 606 $aImmunology 606 $aClinical biochemistry 606 $aCell Biology 606 $aImmunology 606 $aMedical Biochemistry 615 0$aCytology. 615 0$aImmunology. 615 0$aClinical biochemistry. 615 14$aCell Biology. 615 24$aImmunology. 615 24$aMedical Biochemistry. 676 $a571.6 700 $aLama$b Polly$01439871 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911021142303321 996 $aThe Biological Role of Small Leucine-Rich Proteoglycans (SLRPs) in Matrix Homeostasis and Diseases$94427107 997 $aUNINA