LEADER 02724nam 22006614a 450 001 9911020438903321 005 20251116153007.0 010 $a9786611381455 010 $a9781281381453 010 $a1281381454 010 $a9780470281895 010 $a0470281898 010 $a9780470281871 010 $a0470281871 035 $a(CKB)1000000000535839 035 $a(EBL)353409 035 $a(OCoLC)476174736 035 $a(SSID)ssj0000112224 035 $a(PQKBManifestationID)11819492 035 $a(PQKBTitleCode)TC0000112224 035 $a(PQKBWorkID)10087746 035 $a(PQKB)11538174 035 $a(MiAaPQ)EBC353409 035 $a(Perlego)2752591 035 $a(EXLCZ)991000000000535839 100 $a20071026d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBioorganic and medicinal chemistry of fluorine /$fJean-Pierre Begue, Daniele Bonnet-Delpon ; translated from French by Julien Legros 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2008 215 $a1 online resource (385 p.) 300 $aTranslated from the French. 311 08$a9780470278307 311 08$a0470278307 320 $aIncludes bibliographic references and index. 327 $aGeneral remarks on structural, physical, and chemical properties of fluorinated compounds -- Overview on the preparation of fluorinated compounds -- Effects of fluorine substitution on biological properties -- Fluorinated analogues of natural products -- Fluorinated derivatives of ?-amino acids and proteins -- Saccharidic fluorinated derivatives -- Inhibition of enzymes by fluorinated compounds -- Fluorinated drugs. 330 $a Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes 606 $aFluorine compounds$xTherapeutic use 606 $aFluorine$xPhysiological effect 606 $aOrganofluorine compounds 606 $aBioorganic chemistry 615 0$aFluorine compounds$xTherapeutic use. 615 0$aFluorine$xPhysiological effect. 615 0$aOrganofluorine compounds. 615 0$aBioorganic chemistry. 676 $a547/.02 700 $aBe?gue?$b Jean-Pierre$00 701 $aBonnet-Delpon$b Danie?le$00 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020438903321 996 $aBioorganic and medicinal chemistry of fluorine$94416483 997 $aUNINA