LEADER 03963nam  22006975  450 
001 9911020423003321
005 20251023122148.0
010   $a981-9688-73-6
024 7 $a10.1007/978-981-96-8873-9
035   $a(CKB)40259239200041
035   $a(MiAaPQ)EBC32261130
035   $a(Au-PeEL)EBL32261130
035   $a(DE-He213)978-981-96-8873-9
035   $a(EXLCZ)9940259239200041
100   $a20250812d2025      u|         0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aCellular Senescence and Brain Aging $eMechanisms, Therapeutic Strategies, and Implications for Neurodegenerative Diseases /$fedited by Gaurav Gupta
205   $a1st ed. 2025.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025.
215   $a1 online resource (344 pages)
311 08$a981-9688-72-8 
327   $aChapter1.. Aging and Neurodegeneration -- Chapter2.. Introduction to Cellular Senescence -- Chapter3.. Introduction to Senescence-Associated Secretory Phenotype (SASP) -- Chapter4.. Cellular senescence in the aging brain -- Chapter5.. Neurodegeneration in the aging brain: role of cellular senescence -- Chapter6.. Cellular senescence in Alzheimer's Disease (AD) -- Chapter7.. Cellular senescence in Parkinson's Disease (PD) -- Chapter8.. Cellular senescence in Huntington's Disease (HD) -- Chapter9.. Cellular senescence in Amyotrophic Lateral Sclerosis (ALS) -- Chapter10.. Cellular senescence in Vascular Dementia (VaD) -- Chapter11.. Cellular senescence in Multiple Sclerosis (MS) -- Chapter12.. Future Prospects and Challenges.
330   $aThe book examines the cellular senescence in brain aging processes and its effects on three major neurodegenerative conditions: Alzheimer?s disease, Parkinson?s disease, and Huntington?s disease. It discusses basic aging mechanisms, including oxidative stress, mitochondrial dysfunction, and neuroinflammation, before moving on to current treatments such as senolytics and autophagy modulators. The book is divided into several chapters, with specific sections dedicated to experimental approaches, detection methods, and disease-by-disease analysis of cellular senescence effects. A specific chapter explores the clinical potential of senescence-targeting therapies and discusses upcoming study pathways. This publication is aimed at researchers in neuroscience, clinicians, graduate students, neuroscientists, and neuropharmacology professionals involved in the assessment of age-related disorders. It delivers thorough expertise by combining research evidence on brain aging with methods to combat cognitive decline. The structured system within this publication creates connections between basic research and medical implementation, providing essential knowledge for treating neurodegeneration.
606   $aNeurosciences
606   $aNervous system$xDiseases
606   $aNeurophysiology
606   $aNeurons
606   $aNeuroimmunology
606   $aPsychobiology
606   $aHuman behavior
606   $aNeuroscience
606   $aNeurological Disorders
606   $aCellular Neuroscience
606   $aNeuroimmunology
606   $aBehavioral Neuroscience
615  0$aNeurosciences.
615  0$aNervous system$xDiseases.
615  0$aNeurophysiology.
615  0$aNeurons.
615  0$aNeuroimmunology.
615  0$aPsychobiology.
615  0$aHuman behavior.
615 14$aNeuroscience.
615 24$aNeurological Disorders.
615 24$aCellular Neuroscience.
615 24$aNeuroimmunology.
615 24$aBehavioral Neuroscience.
676   $a612.8
676   $a618.9768
700   $aGupta$b Gaurav$0929074
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9911020423003321
996   $aCellular Senescence and Brain Aging$94420266
997   $aUNINA