LEADER 05399nam 22007094a 450 001 9911020374203321 005 20200520144314.0 010 $a9786612342929 010 $a9781119965619 010 $a1119965616 010 $a9781282342927 010 $a1282342924 010 $a9780470725726 010 $a0470725729 010 $a9780470725719 010 $a0470725710 035 $a(CKB)1000000000687510 035 $a(EBL)470121 035 $a(SSID)ssj0000303507 035 $a(PQKBManifestationID)11227118 035 $a(PQKBTitleCode)TC0000303507 035 $a(PQKBWorkID)10276610 035 $a(PQKB)11468947 035 $a(MiAaPQ)EBC470121 035 $a(OCoLC)264621008 035 $a(Perlego)1011612 035 $a(EXLCZ)991000000000687510 100 $a20080125d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular epidemiology of chronic diseases /$feditors, Chris Wild, Paolo Vineis, Seymour Garte 210 $aChichester, England ;$aHoboken, NJ $cJ. Wiley$dc2008 215 $a1 online resource (386 p.) 300 $aDescription based upon print version of record. 311 08$a9780470027431 311 08$a0470027436 320 $aIncludes bibliographical references and index. 327 $aMOLECULAR EPIDEMIOLOGY OF CHRONICDISEASES; Contents; Contributors; Acknowledgements; 1 Introduction: why molecular epidemiology?; 2 Study design; 2.1. Introduction: study design at square one; 2.2. Epidemiological measures; 2.3. Bias; 2.4. More on confounding; 2.5. Specifi cities of molecular epidemiology design; 2.6. Conclusions; References; Essential reading; 3 Molecular epidemiological studies that can be nested within cohorts; 3.1. Introduction; 3.2. Case-cohort studies; 3.3. Nested case-control studies 327 $a3.4. Considerations regarding biomarker analyses in case-cohort and nested case-control studies3.5. Conclusion; References; 4 Family studies, haplotypes and gene association studies; 4.1. Introduction; 4.2. Family studies; 4.3. Genetic association studies; 4.4. Discussion; References; 5 Individual susceptibility and gene-environment interaction; 5.1. Individual susceptibility; 5.2. Genetic susceptibility; 5.3. Metabolic susceptibility genes; 5.4. Study designs; 5.5. Gene-environment interaction; 5.6. Exposure dose effects in gene-environment interactions 327 $a5.7. Mutational effects of gene-environment interactions5.8. Conclusions; References; 6 Biomarker validation; 6.1. Validity and reliability; 6.2. Biomarker variability; 6.3. Measurement of variation; 6.4. Other issues of validation; 6.5. Measurement error; 6.6. Blood collection for biomarkers; 6.7. Validation of high-throughput techniques; References; 7 Exposure assessment; 7.1. Introduction; 7.2. Initial considerations of an exposure assessment strategy; 7.3. Exposure pathways and routes; 7.4. Exposure dimensions; 7.5. Exposure classifi cation, measurement or modelling 327 $a7.6. Retrospective exposure assessment7.7. Validation studies; 7.8. Quality control issues; References; 8 Carcinogen metabolites as biomarkers; 8.1. Introduction; 8.2. Overview of carcinogen metabolism; 8.3. Examples of carcinogen metabolite biomarkers; 8.4. Summary; References; 9 Biomarkers of exposure: adducts; 9.1. Introduction; 9.2. Methods for adduct detection; 9.3. Adducts identifi ed in human tissue; 9.4. Adducts as biomarkers of occupational and environmental exposure to carcinogens; 9.5. Smoking-related adducts; 9.6. DNA adducts in prospective studies; 9.7. Conclusions; References 327 $a10 Biomarkers of mutation and DNA repair capacity10.1. Introduction; 10.2. Classifi cation of mutations; 10.3. Mutations in molecular epidemiology; 10.4. DNA repair; 10.5. Classes of DNA repair; 10.6. Common assays to measure DNA repair capacity; 10.7. Integration of DNA repair assays into epidemiological studies; 10.8. Genetic markers for DNA repair capacity; References; 11 High-throughput techniques - genotyping and genomics; 11.1. Introduction; 11.2. Background; 11.3. SNP databases; 11.4. Study types; 11.5. Study design; 11.6. Genotyping technologies 327 $a11.7. Sample and study management and QC 330 $a""I think this is an excellent book-I recommend it to anyone involved in molecular epidemiology... The 26 chapters are written by topic specialists, in an explanatory, east to read style."" -BTS Newsletter, Summer 2009 ""This text provides an accessible and useful handbook for the epidemiologist who wants to survey the field, to become better informed, to look at recent developments and get some background on these or simply to appreciate further the relatively rapid changes in informatic and analytical technologies which increasingly will serve and underpin future epidemiol 606 $aMolecular epidemiology 606 $aChronic diseases$xEpidemiology 615 0$aMolecular epidemiology. 615 0$aChronic diseases$xEpidemiology. 676 $a614.4 701 $aWild$b Chris$f1959-$01839325 701 $aVineis$b Paolo$0451157 701 $aGarte$b Seymour J$01839326 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020374203321 996 $aMolecular epidemiology of chronic diseases$94418522 997 $aUNINA