LEADER 04988nam 2200709 a 450 001 9911020363003321 005 20200520144314.0 010 $a9786613679529 010 $a9781280768750 010 $a1280768754 010 $a9780470719251 010 $a0470719257 010 $a9780470716762 010 $a0470716762 035 $a(CKB)1000000000687683 035 $a(EBL)703771 035 $a(SSID)ssj0000715178 035 $a(PQKBManifestationID)11434928 035 $a(PQKBTitleCode)TC0000715178 035 $a(PQKBWorkID)10700526 035 $a(PQKB)11300350 035 $a(MiAaPQ)EBC703771 035 $a(OCoLC)264621110 035 $a(Perlego)2759770 035 $a(EXLCZ)991000000000687683 100 $a19840321d1962 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCiba Foundation Symposium, jointly with Co-ordinating Committee for Symposia on Drug Action, on Enzymes and Drug Action /$feditor for the Co-ordinating Committee, J.L. Mongar ; editor for the Ciba Foundation, A.V.S. de Reuck 210 $aBoston $cLittle, Brown$d1962 215 $a1 online resource (581 p.) 225 1 $aCiba Foundation symposium 300 $aDescription based upon print version of record. 311 08$a9780470722695 311 08$a047072269X 320 $aIncludes bibliographical references and indexes. 327 $aENZYMES AND DRUG ACTION; CONTENTS; Wellcome Building Sessions; Session 1: Enzymes as Primary Points of Drug Action; Chairman's introduction; Inhibition of acetylcholinesterase; Discussion; Carbonic anhydrase inhibition and physiological function; Discussion; Session 2: Active Transport; Pinocytosis; Discussion; Possible mechanisms of active transport; Discussion; Effects of drugs on active transport; Discussion; Session 3: Multiple Mechanisms; I. Insulin; The explanation of the action of insulin on sugar permeability at molecular level; Action of insulin on metabolic reactions; Discussion 327 $aII. DigitalisAction of cardiac glycosides on ionic movements; Digitalis: action on metabolism and the contractile system; Discussion; III. Central Nervous System Depressants; Action of barbiturates upon respiratory enzymes; Appraising enzymic actions of central depressants by examining cerebral tissues; Discussion; Session 4: Receptors; Relation between enzymes and cholinergic receptors; Discussion; Induction of receptors; Discussion; Session 5: Altered Drug Metabolism; Chairman's introduction; Adaptive enzymes in animals; Discussion; Drug tolerance; Discussion 327 $aThe genetics of drug sensitivity with special reference to suxamethoniumDiscussion; Session 6: Drug Metabolism: Subcellular Aspects; Drug metabolism-subcellular mechanisms; Discussion; Cellular injury by drugs; Protection against cellular injury by drugs; Discussion; Panel Discussion; Ciba Foundation Sessions on Drug-Enzyme Interaction at the Molecular Level; Session 1: Enzymes; Introduction: Enzymes; Models of active centres: acetylcholine; Active transport; Mode of action of insulin; Limitations of enzymes as models; Session 2: Receptors; Introduction: Receptors; Definition of receptors 327 $aIdentifying active centresEffect of denervation on receptors; Events at the cell membrane; Rate theory of drug action; Interaction at the Subcellular and Cellular Levels; Session 3: Subcellular Level; Introduction: Membranes; Subcellular particles; Phosphatidic acid cycle; Antihistamines and membrane permeability; Drug concentrations in vitro; Session 4: Cellular Level; Introduction: Cellular aspects; Reconstituting in vitro; In vitro and in vivo; Microsomal enzymes; Endoplasmic reticulum; Enzymes in young animals; Transaminase and GABA; Drug interactions; General considerations 330 8 $aThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. 410 0$aCiba Foundation symposium. 606 $aEnzymes$vCongresses 606 $aDrugs$xPhysiological effect$vCongresses 606 $aDrugs$xMetabolism$vCongresses 615 0$aEnzymes 615 0$aDrugs$xPhysiological effect 615 0$aDrugs$xMetabolism 676 $a612.0151 701 $aMongar$b J. L$01275307 701 $aDe Reuck$b Anthony V. S$0290946 712 02$aBiological Council.$bCo-ordinating Committee for Symposia on Drug Action. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020363003321 996 $aCiba Foundation Symposium, jointly with Co-ordinating Committee for Symposia on Drug Action, on Enzymes and Drug Action$93005150 997 $aUNINA