LEADER 04011nam 22005053 450 001 9911020342403321 005 20250608090416.0 010 $a1-394-23614-X 010 $a1-394-23613-1 035 $a(MiAaPQ)EBC32148645 035 $a(Au-PeEL)EBL32148645 035 $a(CKB)39171251400041 035 $a(OCoLC)1522997052 035 $a(BIP)119114563 035 $a(BIP)95900576 035 $a(EXLCZ)9939171251400041 100 $a20250608d2025 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCharacterizing Biotherapeutics $eAnalytical Methods for Diverse Modalities 205 $a1st ed. 210 1$aNewark :$cJohn Wiley & Sons, Incorporated,$d2025. 210 4$dİ2025. 215 $a1 online resource (477 pages) 311 08$a1-394-23611-5 330 $aProvides detailed and up-to-date coverage of analytical approaches for biologic drug modalities The development of innovative biologic therapies has revolutionized medicine, but their complexity demands equally advanced analytical approaches. Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities introduces the tools and techniques used to analyze these groundbreaking therapies. Designed to help readers characterize and troubleshoot increasingly diverse and sophisticated therapeutic molecules, this in-depth guide addresses different biologic drugs, their unique analytical challenges, and the methods that enable their analysis. Organized into two comprehensive sections, Characterizing Biotherapeutics first delves into the fundamentals of analytical platforms, providing a robust foundation in techniques such as mass spectrometry and biophysical assays. The second section applies these methods to real-world scenarios, focusing on drug discovery, clinical evaluation, and commercial considerations in drug development. Authors Jennie R. Lill and Wendy Sandoval provide clear guidance tailored to the evolving demands of therapeutic innovations such as structural characterization, high-throughput biophysical assays, and RNA-based therapeutics. Equipping researchers with the knowledge to navigate the challenges posed by increasingly complex biologics, Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities: Discusses new and emerging biological molecule diversity and both traditional analytical methods Provides characterization strategies for large molecule (protein/antibody) based therapeutics Summarizes cutting-edge technologies for novel modalities and antibody protein therapeutics Incorporates the latest advancements in mass spectrometry, functional assays, and biophysical methods Addresses specialized analytical issues for membrane proteins and other challenging targets Presents methodologies for assessing safety and therapeutic potential Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities is an essential reference for analytical scientists, biologists, and mass spectrometrists involved in biomolecule analysis. It is also a valuable resource for graduate students taking advanced courses in biotechnology, drug development, and biotherapeutic analysis, as well as professionals in biotechnology and pharmaceutical industries working to advance biotherapeutic research and development. 606 $aSCIENCE / Chemistry / Analytic$2bisacsh 606 $aSCIENCE / Life Sciences / Biochemistry$2bisacsh 606 $aSCIENCE / Life Sciences / Molecular Biology$2bisacsh 615 7$aSCIENCE / Chemistry / Analytic 615 7$aSCIENCE / Life Sciences / Biochemistry 615 7$aSCIENCE / Life Sciences / Molecular Biology 676 $a615.7 700 $aLill$b Jennie R$01837602 701 $aSandoval$b Wendy$01837603 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020342403321 996 $aCharacterizing Biotherapeutics$94416357 997 $aUNINA