LEADER 03935nam 2200721Ia 450 001 9911020342103321 005 20200520144314.0 010 $a9786612687549 010 $a9781118211571 010 $a111821157X 010 $a9781282687547 010 $a1282687549 010 $a9780470409817 010 $a0470409819 010 $a9780470409800 010 $a0470409800 035 $a(CKB)1000000000687274 035 $a(EBL)469826 035 $a(OCoLC)317483221 035 $a(SSID)ssj0000198584 035 $a(PQKBManifestationID)11171664 035 $a(PQKBTitleCode)TC0000198584 035 $a(PQKBWorkID)10171307 035 $a(PQKB)10260312 035 $a(MiAaPQ)EBC469826 035 $a(Perlego)1007650 035 $a(EXLCZ)991000000000687274 100 $a20080509d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMass spectrometry in drug metabolism and pharmacokinetics /$fedited by Ragu Ramanathan 210 $aHoboken, N.J. $cWiley$dc2009 215 $a1 online resource (403 p.) 300 $aDescription based upon print version of record. 311 08$a9780471751588 311 08$a0471751588 320 $aIncludes bibliographical references and index. 327 $aMass Spectrometry in Drug Metabolism and Pharmacokinetics; Contents; Preface; About the Editor; Contributors; 1. Evolving Role of Mass Spectrometry in Drug Discovery and Development; 2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications; 3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis; 4. Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening; 5. Changing Role of FTMS in Drug Metabolism 327 $a6. High-Resolution LC-MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection7. Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies; 8. Online Electrochemical-LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants; 9. LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine; 10. Turbulent-Flow LC-MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification 327 $a11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals; Index 330 $aThis timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scien 410 0$aWiley UBCM ebooks. 606 $aDrugs$xDesign 606 $aDrugs$xMetabolism$xResearch$xMethodology 606 $aMass spectrometry 606 $aPharmacokinetics$xResearch$xMethodology 615 0$aDrugs$xDesign. 615 0$aDrugs$xMetabolism$xResearch$xMethodology. 615 0$aMass spectrometry. 615 0$aPharmacokinetics$xResearch$xMethodology. 676 $a615/.7 686 $aVS 5300$2rvk 701 $aRamanathan$b Ragu$0318435 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020342103321 996 $aMass spectrometry in drug metabolism and pharmacokinetics$94416356 997 $aUNINA