LEADER 04129nam 2200757 a 450 001 9911020245403321 005 20200520144314.0 010 $a9786612122460 010 $a9781282122468 010 $a1282122460 010 $a9780470514863 010 $a0470514868 010 $a9780470514870 010 $a0470514876 035 $a(CKB)1000000000376022 035 $a(EBL)470484 035 $a(OCoLC)646516147 035 $a(SSID)ssj0000388240 035 $a(PQKBManifestationID)11250450 035 $a(PQKBTitleCode)TC0000388240 035 $a(PQKBWorkID)10431000 035 $a(PQKB)10524275 035 $a(MiAaPQ)EBC470484 035 $a(Perlego)2761003 035 $a(EXLCZ)991000000000376022 100 $a19951206d1996 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGrowth factors as drugs for neurological and sensory disorders /$f[editors, Gregory R. Bock (organizer) and Jamie A. Goode] 210 $aChichester ;$aNew York $cWiley$d1996 215 $a1 online resource (265 p.) 225 1 $aCiba Foundation symposium ;$v196 300 $aPapers presented at a symposium held at the Ciba Foundation, London, 25-27 April 1995. 311 08$a9780471957218 311 08$a0471957216 320 $aIncludes bibliographical references and indexes. 327 $aGROWTH FACTORS AS DRUGS FOR NEUROLOGICAL AND SENSORY DISORDERS; Contents; Participants; Introduction; Motor neuron disease and model systems: aetiologies, mechanisms and therapies; Potential utility of rhlGF-1 in neu romuscular and/or degenerative disease; Therapeutic potential of the n e u rot ro p h i n s and n e u rot ro p h i n-C NT F combinations in peripheral neuropathies and motor neuron diseases; Development of neurotrophic factor therapy for Alzheimer's disease 327 $aGrowth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-bSomatic gene therapy for nervous system disease; Neurotrophic factors in the treatment of peripheral neuropathy; General discussion I; Growth factors in the treatment of degenerative retinal disorders; Effects of neurotrophins on the survival and regrowth of injured retinal neurons; Neurotrophic factors as pharmacological agents for the treatment of injured auditory neurons; Growth factors as potential drugs for the sensory epithelia of the ear 327 $aFactors affecting neuronal birth and death in the mammalian olfactory epithelium The problems of delivering neuroactive molecules to the CNS; Closing remarks; Index of contributors; Subject index 330 $aDegeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear. 410 0$aCiba Foundation symposium ;$v196. 606 $aNervous system$xDegeneration$xChemotherapy$vCongresses 606 $aNerve growth factor$xTherapeutic use$vCongresses 606 $aNeurotropin$xTherapeutic use$vCongresses 606 $aGrowth factors$xTherapeutic use$vCongresses 606 $aAfferent pathways$xDiseases$xChemotherapy$vCongresses 606 $aSensory disorders$xChemotherapy$vCongresses 615 0$aNervous system$xDegeneration$xChemotherapy 615 0$aNerve growth factor$xTherapeutic use 615 0$aNeurotropin$xTherapeutic use 615 0$aGrowth factors$xTherapeutic use 615 0$aAfferent pathways$xDiseases$xChemotherapy 615 0$aSensory disorders$xChemotherapy 676 $a616.8/0461 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020245403321 996 $aGrowth factors as drugs for neurological and sensory disorders$94422476 997 $aUNINA