LEADER 02658nam 2200601 a 450 001 9910791824703321 005 20200520144314.0 010 $a1-61728-253-7 035 $a(CKB)2560000000070112 035 $a(EBL)3019954 035 $a(SSID)ssj0000470688 035 $a(PQKBManifestationID)12158892 035 $a(PQKBTitleCode)TC0000470688 035 $a(PQKBWorkID)10412442 035 $a(PQKB)11495966 035 $a(MiAaPQ)EBC3019954 035 $a(Au-PeEL)EBL3019954 035 $a(CaPaEBR)ebr10674962 035 $a(OCoLC)923662206 035 $a(EXLCZ)992560000000070112 100 $a20090920d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aKaryogamic theory of cancer cell formation from the view of the XXI century$b[electronic resource] /$fG. Gogichadze and T. Gogichadze 210 $aNew York $cNova Biomedical Books$dc2010 215 $a1 online resource (195 p.) 225 1 $aCancer etiology, diagnosis and treatments series 300 $aDescription based upon print version of record. 311 $a1-60876-386-2 320 $aIncludes bibliographical references and index. 327 $aHistory of the problem -- Hybrid cells receiving methods and mechanism of cells fusion -- Geno- and phenotypic characteristics of hybrid cells -- Utilization of somatic hybridization in biology and medicine -- Etiology and pathogenesis of cancer -- Factors, induced the malignant process -- The theory of "two synkaryons" -- Experimental and clinical confirmations of the "two synkaryons" theory -- Explanation of differented complicated aspects of the experimental and clinical oncology from the standpoint of the "two synkaryons" theory -- Etiology and pathogenesis of AIDS -- Possible common etiology and pathogenesis of cancer and AIDS -- A possible reason for interrelation of some malignant tumors and AIDS -- A paradoxical idea of cancer's resolution. 410 0$aCancer etiology, diagnosis, and treatments. 606 $aCarcinogenesis 606 $aCancer cells 606 $aCell hybridization 606 $aAIDS (Disease)$xEtiology 615 0$aCarcinogenesis. 615 0$aCancer cells. 615 0$aCell hybridization. 615 0$aAIDS (Disease)$xEtiology. 676 $a616.99/4071 700 $aGogichadze$b G. K$01478466 701 $aGogichadze$b T$01478467 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910791824703321 996 $aKaryogamic theory of cancer cell formation from the view of the XXI century$93694140 997 $aUNINA LEADER 05396nam 2200697Ia 450 001 9911020238503321 005 20200520144314.0 010 $a9786611758660 010 $a9781281758668 010 $a1281758663 010 $a9783527615452 010 $a3527615458 010 $a9783527615445 010 $a352761544X 035 $a(CKB)1000000000540642 035 $a(EBL)481430 035 $a(SSID)ssj0000120638 035 $a(PQKBManifestationID)11141696 035 $a(PQKBTitleCode)TC0000120638 035 $a(PQKBWorkID)10081830 035 $a(PQKB)11031127 035 $a(MiAaPQ)EBC481430 035 $a(OCoLC)214281425 035 $a(Perlego)2755343 035 $a(EXLCZ)991000000000540642 100 $a19941215d1995 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aChemometric methods in molecular design /$fedited by Han van de Waterbeemd 210 $aWeinheim, Ger. ;$aNew York $cVCH$dc1995 215 $a1 online resource (380 p.) 225 1 $aMethods and principles in medicinal chemistry ;$vv. 2 300 $aDescription based upon print version of record. 311 08$a9783527300440 311 08$a3527300449 320 $aIncludes bibliographical references and index. 327 $aChernornetric Methods in Molecular Design; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 Quantitative Molecular Design; 1.2 Chemometrics; 1.3 The Hansch Approach; 1.4 Modern Chemometric Approaches in Molecular Design; 1.5 Software; 1.5.1 General Statistical Packages; 1.5.2 Specialized Software for SPC Studies; References; 2 Molecular Concepts; 2.1 Representations of Molecules; 2.1.1 Introduction; 2.1.2 Substituent Constants; 2.1.2.1 Electronic Substituent Constants; 2.1.2.2 The Hydrophobic Substituent Constant,p; 2.1.2.3 Partition Coefficient - Log P 327 $a2.1.2.4 Steric Substituent Constants2.1.3 Whole Molecule Representations; 2.1.3.1 Topological Descriptions; 2.1.3.2 Electronic Whole Molecule Descriptors; 2.1.3.3 Geometric Descriptors; References; 2.2 Atom-Level Descriptors for QSAR Analyzes; 2.2.1 Introduction; 2.2.2 An Atom-Level Description of Structure; 2.2.2.1 The Field; 2.2.2.2 The Intrinsic State of an Atom; 2.2.2.3 The Field Effect on Each Atom; 2.2.3 Strategies for Use of E-State Indices; 2.2.4 Examples of E-State QSAR; 2.2.4.1 MAO Inhibition with Hydrazides; 2.2.4.2 Adenosine A, Inhibitors 327 $a2.2.4.3 Anesthetic Concentration of Haloalkanes2.2.4.4 Odor Sensitivity of Pyrazines; 2.2.5 Conclusions; References; 3 Experimental Design in Synthesis Planning and Structure-Property Correlations; 3.1 Experimental Design; 3.1.1 The Importance of Experimental Design in Medicinal Chemistry; 3.1.2 Strategy in Experimental Design; 3.1.3 Selected Methods for Experimental Design; 3.1.3.1 Methods for the Direct Optimization of Lead Compounds; 3.1.3.2 Methods for the Systematic Investigation of Parameter Space; 3.1.3.3 Choice of Molecular Descriptors; 3.1.4 Summary and Conclusion; References 327 $a3.2 Applications of Statistical Experimental Design and PLS Modeling in QSAR3.2.1 Introduction; 3.2.2 A Strategy for QSAR Development in Drug Design; 3.2.2.1 Formulation of Classes of Similar Compounds (Step 1); 3.2.2.2 Structural Description and Definition of Design Variables (Step 2); 3.2.2.3 Selection of the Training Set of Compounds (Step 3); 3.2.2.4 Biological Testing (Step 4); 3.2.2.5 QSAR Development (Step 5; 3.2.2.6 Validation and Predictions for Non-Tested Compounds (Step; 3.2.3 Examples of Design and PLS Modeling; 3.2.3.1 Bradykinin Potentiating Pentapeptides 327 $a3.2.3.2 Dipeptides (Inhibiting the Angiotensin Converting Enzyme)3.2.3.3 Dipeptides (Bitter Tasting); 3.2.3.4 Mimetics; 3.2.3.5 Haloalkanes; 3.2.3.6 Dibenzofurans; 3.2.3.7 Monosubstituted Benzenes; 3.2.3.8 Corrosive Carboxylic Acids; 3.2.4 Discussion and Conclusions; Software Used; Acknowledgements; References; 3.3 Total Response Surface Optimization; 3.3.1 Background; 3.3.2 Representation of a Response Surface; 3.3.3 Structure Descriptors from Chemical Graph Theory; 3.3.4 Examples; 3.3.4.1 Neurotoxicity of Fluorophosphorous Compounds 327 $a3.3.4.2 Bioconcentration of Chlorinated Phenyls and Biphenyls 330 $aThe statistical analysis of experimental and theoretical data lies at the heart of modern drug design. This practice-oriented handbook is a comprehensive account of modern chemometric methods in molecular design. It presents strategies for making more rational choices in the planning of syntheses, and describes techniques for analyzing biological and chemical data. Written by the world's experts, it provides in-depth information on* molecular concepts* experimental design in the planning of syntheses* multivariate analysis of chemical and biological data* statistical validation 410 0$aMethods and principles in medicinal chemistry ;$vv. 2. 606 $aQSAR (Biochemistry) 606 $aDrugs$xDesign 615 0$aQSAR (Biochemistry) 615 0$aDrugs$xDesign. 676 $a547.13 676 $a615/.1901 701 $aWaterbeemd$b Han van de$0860600 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020238503321 996 $aChemometric methods in molecular design$92181934 997 $aUNINA