LEADER 05239nam 2200685Ia 450 001 9911020146103321 005 20200520144314.0 010 $a9786612460852 010 $a9781282460850 010 $a1282460854 010 $a9783527626847 010 $a3527626840 010 $a9783527626830 010 $a3527626832 035 $a(CKB)1000000000802822 035 $a(EBL)482029 035 $a(OCoLC)566133558 035 $a(SSID)ssj0000341344 035 $a(PQKBManifestationID)11257586 035 $a(PQKBTitleCode)TC0000341344 035 $a(PQKBWorkID)10389901 035 $a(PQKB)10691824 035 $a(MiAaPQ)EBC482029 035 $a(PPN)152509879 035 $a(Perlego)2765706 035 $a(EXLCZ)991000000000802822 100 $a20090506d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aPeptides as drugs $ediscovery and development /$fedited by Bernd Groner 210 $aWeinheim $cWiley-VCH$dc2009 215 $a1 online resource (244 p.) 300 $aDescription based upon print version of record. 311 08$a9783527322053 311 08$a3527322051 320 $aIncludes bibliographical references and index. 327 $aPeptides as Drugs; Contents; Preface; List of Contributors; 1: Peptides as Drugs: Discovery and Development; 1.1 Discovery of New Potential Drug Targets and the Limitations of Druggability; 1.2 Protein Interaction Domains Are at the Core of Signaling Pathways; 1.3 Peptides as Inhibitors of Protein Interactions; References; 2: Mimics of Growth Factors and Cytokines; 2.1 Introduction; 2.2 The Cytokines; 2.2.1 The Receptors; 2.2.2 "Simple" Receptors; 2.2.3 "Complex" Receptors; 2.3 Defining Receptor Recognition Sites in Cytokines Using Chimeric Proteins 327 $a2.4 Receptor Recognition Sites are Organized as Exchangeable Modules2.5 The Concept of Fusing the Cytokine to the Soluble Receptor: Hyper-IL-6; 2.6 Antagonists Specifically Inhibiting IL-6 Trans-Signaling; 2.7 In Vitro Evolution of Peptides and Proteins; 2.7.1 Platforms for the Selection of High-Affinity Binders; 2.7.2 Agonists and Antagonists of Cytokines and Growth Hormones; 2.8 Concluding Remarks; References; 3: Peptides Derived from Exon v6 of the CD44 Extracellular Domain Prevent Activation of Receptor Tyrosine Kinases and Subsequently Angiogenesis and Metastatic Spread of Tumor Cells 327 $a3.1 Introduction3.2 CD44 Proteins and Their Involvement in RTK Activation; 3.3 CD44v6 Acts as a Coreceptor for c-Met and Ron; 3.4 Three Amino Acids in CD44 Exon v6 Are Crucial for the CD44v6 Coreceptor Function, and Small Peptides Can Interfere with This Function; 3.5 The Ectodomain of CD44v6 Binds to HGF; 3.6 Peptides Corresponding to Exon v6 of CD44 Inhibit Metastatic Spread of Tumor Cells; 3.7 The Significance of the Collaboration between CD44v6 and c-Met In Vivo; 3.8 The CD44v6 Peptides Interfere with Angiogenesis; 3.9 Outlook; References 327 $a4: Peptide Aptamers Targeting the Viral E6 Oncoprotein Induce Apoptosis in HPV-positive Cancer Cells4.1 Human Papillomaviruses and Oncogenesis; 4.1.1 Cervical Cancer; 4.1.2 The E6 and E7 Genes; 4.2 Peptide Aptamers Targeting the HPV E6 Oncoprotein; 4.3 E6-Targeting Peptide Aptamers: Therapeutic Perspectives; 4.3.1 Therapeutic Target Protein Evaluation by Peptide Aptamers; 4.3.2 The Intrinsic Therapeutic Potential of Peptide Aptamers; 4.3.3 Identification of Functional Peptide Mimics by Displacement Screening; 4.4 Perspectives; References 327 $a5: The Prevention of HIV Infection with Viral Entry Inhibitors5.1 Introduction: The Potential of Peptides as Drugs in the Treatment of HIV Infection; 5.2 The HIV Entry Process; 5.3 Peptides that Inhibit Receptor or Coreceptor Binding; 5.3.1 Physiological Antimicrobial Peptides; 5.3.1.1 Defensins; 5.3.2 Chemokines; 5.3.3 Synthetic Peptides and Peptidomimetics; 5.4 Inhibitors of the Viral and Cellular Membrane Fusion Process; 5.5 Entry Inhibitory Peptides Selected by the Phage Display Technology; 5.6 Limitations of Peptides in the Treatment of HIV Infection 327 $a5.7 Strategies to Prolong the In Vivo Half-Life of Antiviral Peptides 330 $aBy covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class.The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs.With its integration of b 606 $aDrugs$xDesign 606 $aPeptide drugs 615 0$aDrugs$xDesign. 615 0$aPeptide drugs. 676 $a615.19 676 $a615.3 701 $aGroner$b B$g(Bernd)$01837971 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911020146103321 996 $aPeptides as drugs$94416846 997 $aUNINA LEADER 03868oam 2200697I 450 001 9910957210603321 005 20251117085458.0 010 $a1-4094-2399-9 010 $a1-317-06639-1 010 $a9786612892752 010 $a1-315-60531-7 010 $a1-282-89275-4 010 $a1-4094-0024-7 024 7 $a10.4324/9781315605319 035 $a(CKB)3710000000964642 035 $a(Au-PeEL)EBL4456104 035 $a(CaPaEBR)ebr11463608 035 $a(CaONFJC)MIL975466 035 $a(OCoLC)1011163380 035 $a(OCoLC)948604952 035 $a(MiAaPQ)EBC4456104 035 $a(MiAaPQ)EBC605123 035 $a(EXLCZ)993710000000964642 100 $a20180706e20162010 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aRenaissance theories of vision /$fedited by John Shannon Hendrix and Charles H. Carman 210 1$aLondon ;$aNew York :$cRoutledge,$d2016. 215 $a1 online resource (258 pages) $cillustrations 225 1 $aVisual Culture in Early Modernity 300 $a"An Ashgate book"--Cover. 300 $aFirst published 2010 by Ashgate Publishing. 311 08$a1-4094-8651-6 311 08$a1-317-06640-5 320 $aIncludes bibliographical references and index. 327 $aIntroduction / John S. Hendrix and Charles H. Carman -- Classical optics and the perspectivae traditions leading to the Renaissance / Nader El-Bizri -- Meanings of perspective in the Renaissance : tensions and resolution / Charles Carman -- Criminal vision in early modern Florence : Fra Angelico's altarpiece for "Il Tempio" and the Magdalenian gaze / Allie Terry -- Donatello's Chellini Madonna, light, and vision / Amy R. Bloch -- Perception as a function of desire in the Renaissance / John Hendrix -- Leonardo da Vinci's theory of vision and creativity : the Uffizi Annunciation / Liana De Girolami Cheney -- At the boundaries of sight : the Italian Renaissance cloud putto / Christian Kleinbub -- Gesture and perspective in Raphael's School of Athens / Nicholas Temple -- Seeing and the transfer of spirits in early modern art theory / Thijs Weststeijn -- "All in him selfe as in a glass he sees" : mirrors and vision in the Renaissance / Faye Tudor -- "Nearest the tangible earth" : Rembrandt, Samuel van Hoogstraten, George Berkeley, and the optics of touch / Alice Crawford Berghof. 330 8 $aHow are processes of vision, perception, and sensation conceived in the Renaissance? How are those conceptions made manifest in the arts? The essays in this volume address these and similar questions to establish important theoretical and philosophical bases for artistic production in the Renaissance and beyond. The essays also attend to the views of historically significant writers from the ancient classical period to the eighteenth century, including Plato, Aristotle, Plotinus, St Augustine, Ibn Sina (Avicenna), Ibn al-Haytham (Alhazen), Ibn Sahl, Marsilio Ficino, Nicholas of Cusa, Leon Battista Alberti, Gian Paolo Lomazzo, Gregorio Comanini, John Davies, Rene Descartes, Samuel van Hoogstraten, and George Berkeley. 410 0$aVisual culture in early modernity. 606 $aVisual perception$xHistory 606 $aVision$xHistory 606 $aPerspective$xHistory 606 $aArt$xPhilosophy 606 $aArt, Renaissance 615 0$aVisual perception$xHistory. 615 0$aVision$xHistory. 615 0$aPerspective$xHistory. 615 0$aArt$xPhilosophy. 615 0$aArt, Renaissance. 676 $a701.8 701 $aCarman$b Charles H$0777391 701 $aHendrix$b John$0899828 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910957210603321 996 $aRenaissance theories of vision$94482835 997 $aUNINA