LEADER 01025nam0-2200301---450- 001 990008310090403321 005 20060410125555.0 035 $a000831009 035 $aFED01000831009 035 $a(Aleph)000831009FED01 035 $a000831009 100 $a20060410d1934----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay---n---001yy 200 1 $aCommento teorico-pratico al Nuovo Testo Unico delle Legge Comunale e Provinciale$e(regio decreto 3 marso 1934, n. 383)$eindice sistematico - analitico$fLeonida Macciotta - Cesare Vittorelli 210 $aComo$cTipografia Editrice Cesare Nani$d1934 215 $a760 p.$d24 cm 676 $a342$v11 rid.$zita 700 1$aMacciotta,$bLeonida$0500071 701 1$aVittorelli,$bCesare$0500072 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990008310090403321 952 $aVI G 193$b2619$fDDA 959 $aDDA 996 $aCommento teorico-pratico al Nuovo Testo Unico delle Legge Comunale e Provinciale$9745479 997 $aUNINA LEADER 01315nam a2200229 a 4500 001 991002452549707536 008 140312s 000 0 ita d 035 $ab14176579-39ule_inst 040 $aBibl. Dip.le Aggr. Studi Umanistici - Sez. Filologia Linguistica e Letteratura$bita 100 1 $aFodella, Gianni$0121057 245 10$aRisorse umane per operare nel mercato internazionale :$b le risorse umane italiane con competenza sull'Est-Asia strumento di competività per l'Europa nel mondo : una guida per cooperare e competere /$c Gianni Fodella 260 $aRoma : $bICE, Istituto nazionale per il commercio estero, Dipartimento formazione,$c2001 300 $a163 p. ;$c24 cm 440 0$aCollana di formazione manageriale 500 $aIn testa al frontespizio: ICE, Istituto nazionale per il commercio estero 907 $a.b14176579$b02-04-14$c12-03-14 912 $a991002452549707536 945 $aLE008 FL.M. (Giapp) II A 77 C. 1 $g1$i2008000541798$lle008$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i15596783$z12-03-14 945 $aLE008 FL.M. (Giapp) II A 77 C. 2 $g2$i2008000541804$lle008$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i15596795$z12-03-14 996 $aRisorse umane per operare nel mercato internazionale$9259660 997 $aUNISALENTO 998 $ale008$b12-03-14$cm$da $e-$fita$git $h0$i0 LEADER 05402nam 2200721Ia 450 001 9911019979103321 005 20200520144314.0 010 $a9786613916471 010 $a9783527655748 010 $a3527655743 010 $a9781283604024 010 $a1283604027 010 $a9783527655762 010 $a352765576X 010 $a9783527655779 010 $a3527655778 035 $a(CKB)2670000000253894 035 $a(EBL)1023284 035 $a(SSID)ssj0000741733 035 $a(PQKBManifestationID)11486002 035 $a(PQKBTitleCode)TC0000741733 035 $a(PQKBWorkID)10742950 035 $a(PQKB)11591595 035 $a(MiAaPQ)EBC1023284 035 $a(PPN)178891037 035 $a(OCoLC)811060211 035 $a(Perlego)1012513 035 $a(EXLCZ)992670000000253894 100 $a20111102d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aReactive drug metabolites /$fAmit S. Kalgutkar ...[et. al.] 210 $aWeinheim $cWiley-VCH$d2012 215 $a1 online resource (403 p.) 225 0 $aMethods and principles in medicinal chemistry 300 $aDescription based upon print version of record. 311 08$a9783527330850 311 08$a3527330852 320 $aIncludes bibliographical references and index. 327 $aReactive Drug Metabolites; Contents; Preface; A Personal Foreword; 1 Origin and Historical Perspective on Reactive Metabolites; Abbreviations; 1.1 Mutagenesis and Carcinogenesis; 1.2 Detection of Reactive Metabolites; 1.3 Induction and Inhibition: Early Probes for Reactive Metabolites and Hepatotoxicants; 1.4 Covalent Binding and Oxidative Stress: Possible Mechanisms of Reactive Metabolite Cytotoxicity; 1.5 Activation and Deactivation: Intoxication and Detoxification; 1.6 Genetic Influences on Reactive Metabolite Formation 327 $a1.7 Halothane: the Role of Reactive Metabolites in Immune-Mediated Toxicity1.8 Formation of Reactive Metabolites, Amount Formed, and Removal of Liability; 1.9 Antibodies: Possible Clues but Inconclusive; 1.10 Parent Drug and Not Reactive Metabolites, Complications in Immune-Mediated Toxicity; 1.11 Reversible Pharmacology Should not be Ignored as a Primary Cause of Side Effects; 1.12 Conclusions: Key Points in the Introduction; References; 2 Role of Reactive Metabolites in Genotoxicity; Abbreviations; 2.1 Introduction; 2.2 Carcinogenicity of Aromatic and Heteroaromatic Amines 327 $a2.3 Carcinogenicity of Nitrosamines2.4 Carcinogenicity of Quinones and Related Compounds; 2.5 Carcinogenicity of Furan; 2.6 Carcinogenicity of Vinyl Halides; 2.7 Carcinogenicity of Ethyl Carbamate; 2.8 Carcinogenicity of Dihaloalkanes; 2.9 Assays to Detect Metabolism-Dependent Genotoxicity in Drug Discovery; 2.10 Case Studies in Eliminating Metabolism-Based Mutagenicity in Drug Discovery Programs; References; 3 Bioactivation and Inactivation of Cytochrome P450 and Other Drug-Metabolizing Enzymes; Abbreviations; 3.1 Introduction 327 $a3.2 Pharmacokinetic and Enzyme Kinetic Principles Underlying Mechanism-Based Inactivation and Drug-Drug Interactions3.2.1 Enzyme Kinetic Principles of Mechanism-Based Inactivation; 3.2.2 Pharmacokinetic Principles Underlying DDIs Caused by Mechanism-Based Inactivation; 3.3 Mechanisms of Inactivation of Cytochrome P450 Enzymes; 3.3.1 Quasi-Irreversible Inactivation; 3.3.2 Heme Adducts; 3.3.3 Protein Adducts; 3.4 Examples of Drugs and Other Compounds that are Mechanism-Based Inactivators of Cytochrome P450 Enzymes; 3.4.1 Amines; 3.4.2 Methylenedioxyphenyl Compounds 327 $a3.4.3 Quinones, Quinone Imines, and Quinone Methides3.4.4 Thiophenes; 3.4.5 Furans; 3.4.6 Alkynes; 3.4.7 2-Alkylimidazoles; 3.4.8 Other Noteworthy Cytochrome P450 Inactivators; 3.5 Mechanism-Based Inactivation of Other Drug-Metabolizing Enzymes; 3.5.1 Aldehyde Oxidase; 3.5.2 Monoamine Oxidases; 3.6 Concluding Remarks; References; 4 Role of Reactive Metabolites in Drug-Induced Toxicity - The Tale of Acetaminophen, Halothane, Hydralazine, and Tienilic Acid; Abbreviations; 4.1 Introduction; 4.2 Acetaminophen; 4.2.1 Metabolism of Acetaminophen; 4.2.2 Metabolic Activation of Acetaminophen 327 $a4.3 Halothane 330 $aClosing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the st 410 0$aMethods and Principles in Medicinal Chemistry 606 $aFree radicals (Chemistry)$xPhysiological effect 606 $aDrugs$xMetabolism 615 0$aFree radicals (Chemistry)$xPhysiological effect. 615 0$aDrugs$xMetabolism. 676 $a615.19 700 $aKalgutkar$b Amit S.$f1965-$01838209 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019979103321 996 $aReactive drug metabolites$94417146 997 $aUNINA