LEADER 03236nam 2200649Ia 450 001 9911019963403321 005 20200520144314.0 010 $a9786612342752 010 $a9781282342750 010 $a1282342754 010 $a9780470721551 010 $a0470721553 010 $a9780470721568 010 $a0470721561 035 $a(CKB)1000000000579667 035 $a(EBL)406495 035 $a(SSID)ssj0000157792 035 $a(PQKBManifestationID)11155896 035 $a(PQKBTitleCode)TC0000157792 035 $a(PQKBWorkID)10144410 035 $a(PQKB)11411790 035 $a(MiAaPQ)EBC406495 035 $a(OCoLC)299043657 035 $a(Perlego)2768187 035 $a(EXLCZ)991000000000579667 100 $a20080707d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFragment-based drug discovery $ea practical approach /$feditors, Edward R. Zartler, Michael J. Shapiro 210 $aChichester, U.K. $cJohn Wiley & Sons$d2008 215 $a1 online resource (297 p.) 300 $aDescription based upon print version of record. 311 08$a9780470058138 311 08$a0470058137 320 $aIncludes bibliographical references and index. 327 $aFragment-Based Drug Discovery; Contents; List of Contributors; 1 Introduction to Fragment-based Drug Discovery; 2 Designing a Fragment Process to Fit Your Needs; 3 Assembling a Fragment Library; 4 Practical Aspects of Using NMR in Fragment-based Screening; 5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses; 6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins; 7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry; 8 Computational Approaches to Fragment and Substructure Discovery and Evaluation 327 $a9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools10 Capture Methods for Fragment-based Discovery; 11 Identification of High-affinity -Secretase Inhibitors Using Fragment-based Lead Generation; Index 330 $aFragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical ti 606 $aDrug development 606 $aDrugs$xDesign 606 $aLigands (Biochemistry) 615 0$aDrug development. 615 0$aDrugs$xDesign. 615 0$aLigands (Biochemistry) 676 $a615/.19 701 $aZartler$b Edward$01839103 701 $aShapiro$b Michael$g(Michael J.)$067246 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019963403321 996 $aFragment-based drug discovery$94418229 997 $aUNINA