LEADER 02878nam 2200421 n 450 001 996383679303316 005 20221108102403.0 035 $a(CKB)1000000000581246 035 $a(EEBO)2240887921 035 $a(UnM)99856469 035 $a(EXLCZ)991000000000581246 100 $a19921008d1623 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 15$a[The military art of trayning. With the discipline of drilling all in lively portraytures]$b[electronic resource] 210 $a[[London] $c[E. All-de, solde by R. Daniel$d1622] [1623?]] 215 $a[90] p., [77] leaves of plates $cill. (metal cuts) 300 $aIn two parts. F. S. Ferguson examined both the Huth copies and the British Library copy and drew up the following ideal description: Engraved frontispiece with Mars seated upon a cannon (present only in Huth 4982); part 1 collates A-E F⁴ (A1, letterpress title page; A2, dedication; A3-F2, text, pp. 1-79, [80]; F3,4 blank); part 2 has engraved title page, 44 numbered musket positions, and 33 numbered pike positions, 1 per recto (complete only in Huth 4982), gathered in 12's: [A-F¹² G⁶]. The British Library copy has 4 unnumbered engravings of officers inserted at the beginning of part 2 and some engravings in pen facsimiles. Both Huth copies were resold at Sotheby's, 27 February 1922, lots 153-4, and bought by Ellis. Michigan acquired Huth 4982 in 1936, by which time the engraved frontispiece, musket no. 44, and pike no. 33 were no longer present. The engravings are copies of de Gheyn, cf. STC 11810--Cf. STC. 300 $aTitle, imprint, and suggested actual publication date from STC. 300 $aThe engravings of pike and musket are derived from: Gheyn, Jacob de. The exercise of armes for calivres, muskettes, and pikes. 300 $aEngraved title page has title: The military discipline wherein is most martially shone the order of drilling for ye musket and pike 1623 set forth in postures with the words of command and briefe instructions for the right vse of the same. To be exercised in musters by order form ye lords of his Ma:ties most ho:ble Priuy Counsaile. 300 $aSignatures: pi¹ A-E F⁴. 300 $aImperfect; lacks letterpress title page. 300 $aReproduction of the original in the British Library. 330 $aeebo-0018 606 $aMilitary art and science$zEngland$vEarly works to 1800 606 $aMilitary maneuvers$zEngland$vEarly works to 1800 615 0$aMilitary art and science 615 0$aMilitary maneuvers 701 $aGheyn$b Jacob de$f1565-1629.$0311054 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bCStRLIN 801 2$bWaOLN 906 $aBOOK 912 $a996383679303316 996 $aThe military art of trayning. With the discipline of drilling all in lively portraytures$92348057 997 $aUNISA LEADER 05301nam 22006494a 450 001 9911019954403321 005 20250901160824.0 010 $a1-280-27719-X 010 $a9786610277193 010 $a0-470-35561-1 010 $a0-471-74013-6 010 $a0-471-72781-4 035 $a(CKB)1000000000297443 035 $a(EBL)232612 035 $a(OCoLC)475938695 035 $a(SSID)ssj0000123720 035 $a(PQKBManifestationID)11132685 035 $a(PQKBTitleCode)TC0000123720 035 $a(PQKBWorkID)10008649 035 $a(PQKB)11122381 035 $a(MiAaPQ)EBC232612 035 $a(MiAaPQ)EBC4037039 035 $a(EXLCZ)991000000000297443 100 $a20050214d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aClinical trials $ea methodologic perspective /$fSteven Piantadosi 205 $a2nd ed. 210 $aHoboken, N.J. $cWiley-Interscience$dc2005 215 $a1 online resource (717 p.) 225 1 $aWiley series in probability and statistics 300 $aDescription based upon print version of record. 311 08$a0-471-74012-8 320 $aIncludes bibliographical references (p. 613-658 ) and indexes. 327 $aCLINICAL TRIALS; CONTENTS; Preface; Preface to the First Edition; 1 Preliminaries; 1.1 Introduction; 1.2 Audience and Scope; 1.3 Other Sources of Knowledge; 1.3.1 Terminology; 1.3.2 Review of Notation and Terminology Is Helpful; 1.4 Examples, Data, and Programs; 1.5 Summary; 2 Clinical Trials as Research; 2.1 Introduction; 2.1.1 Clinical Reasoning Is Based on the Case History; 2.1.2 Statistical Reasoning Emphasizes Inference Based on Designed Data Production; 2.1.3 Clinical and Statistical Reasoning Converge in Research; 2.2 Defining Clinical Trials Formally 327 $a2.2.1 Mixing of Clinical and Statistical Reasoning Is Recent2.2.2 Clinical Trials Are Rigorously Defined; 2.2.3 Experiments Can Be Misunderstood; 2.2.4 Clinical Trials as Science; 2.2.5 Trials and Statistical Methods Fit within a Spectrum of Clinical Research; 2.3 Practicalities of Usage; 2.3.1 Predicates for a Trial; 2.3.2 Trials Can Provide Confirmatory Evidence; 2.3.3 Clinical Trials Are Unwieldy, Messy, and Reliable; 2.3.4 Other Methods Are Valid for Making Some Clinical Inferences; 2.3.5 Trials Are Difficult to Apply in Some Circumstances; 2.3.6 Randomized Studies Can Be Initiated Early 327 $a2.4 Summary2.5 Questions for Discussion; 3 Why Clinical Trials Are Ethical; 3.1 Introduction; 3.1.1 Science and Ethics Share Objectives; 3.1.2 Equipoise and Uncertainty; 3.2 Duality; 3.2.1 Clinical Trials Sharpen, but Do Not Create, the Issue; 3.2.2 A Gene Therapy Tragedy Illustrates Duality; 3.2.3 Research and Practice Are Convergent; 3.2.4 The Hippocratic Tradition Does Not Proscribe Clinical Trials; 3.2.5 Physicians Always Have Multiple Roles; 3.3 Historically Derived Principles of Ethics; 3.3.1 Nuremberg Contributed an Awareness of the Worst Problems 327 $a3.3.2 High-Profile Mistakes Were Made in the United States3.3.3 The Helsinki Declaration Was Widely Adopted; 3.3.4 Other International Guidelines Have Been Proposed; 3.3.5 Institutional Review Boards Provide Ethical Oversight; 3.3.6 Ethical Principles Relevant to Clinical Trials; 3.4 Contemporary Foundational Principles; 3.4.1 Collaborative Partnership; 3.4.2 Scientific Value; 3.4.3 Scientific Validity; 3.4.4 Fair Subject Selection; 3.4.5 Favorable Risk-Benefit; 3.4.6 Independent Review; 3.4.7 Informed Consent; 3.4.8 Respect for Subjects; 3.5 Methodologic Reflections 327 $a3.5.1 Practice Based on Unproven Treatments Is Not Ethical3.5.2 Ethics Considerations Are Important Determinants of Design; 3.5.3 Specific Methods Have Justification; 3.6 Professional Conduct; 3.6.1 Conflict of Interest; 3.6.2 Professional Statistical Ethics; 3.7 Summary; 3.8 Questions for Discussion; 4 Contexts for Clinical Trials; 4.1 Introduction; 4.1.1 Some Ways to Learn about Trials in a Given Context; 4.1.2 Issues of Context; 4.2 Drugs; 4.2.1 Are Drugs Special?; 4.2.2 Why Trials Are Used Extensively for Drugs; 4.3 Devices; 4.3.1 Use of Trials for Medical Devices 327 $a4.3.2 Are Devices Different from Drugs? 330 $aLearn rigorous statistical methods to ensure valid clinical trialsThis Second Edition of the critically hailed Clinical Trials builds on the text's reputation as a straightforward and authoritative presentation of statistical methods for clinical trials. Readers are introduced to the fundamentals of design for various types of clinical trials and then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of 410 0$aWiley series in probability and statistics. 606 $aClinical trials$xStatistical methods 615 0$aClinical trials$xStatistical methods. 676 $a610/.72 676 $a615.50724 700 $aPiantadosi$b Steven$01841951 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019954403321 996 $aClinical trials$94421861 997 $aUNINA