LEADER 03725nam 2200697 a 450 001 9911019930003321 005 20200520144314.0 010 $a9786612347627 010 $a9781282347625 010 $a1282347624 010 $a9780470513866 010 $a0470513861 010 $a9780470513873 010 $a047051387X 035 $a(CKB)1000000000377312 035 $a(EBL)470465 035 $a(OCoLC)609849370 035 $a(SSID)ssj0000299288 035 $a(PQKBManifestationID)11278326 035 $a(PQKBTitleCode)TC0000299288 035 $a(PQKBWorkID)10238688 035 $a(PQKB)11700503 035 $a(MiAaPQ)EBC470465 035 $a(Perlego)2762213 035 $a(EXLCZ)991000000000377312 100 $a19890925d1989 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIgE, mast cells, and the allergic response 210 $aChichester ;$aNew York $cJohn Wiley & Sons$d1989 215 $a1 online resource (294 p.) 225 1 $aCiba Foundation symposium ;$v147 300 $a"Symposium on IgE, Mast Cells, and the Allergic Response, held at the Ciba Foundation, London, 11-13 April 1989"--Contents p. 300 $aEdited and organized by Derek Chadwick and others. 300 $a"A Wiley-Interscience publication." 311 08$a9780471923091 311 08$a0471923095 320 $aIncludes bibliographical references and indexes. 327 $aIgE, MAST CELLS AND THE ALLERGIC RESPONSE; Contents; Introduction; Control of in vivo IgE production in the mouse by interleukin 4; Structure and function of FcE receptor II (FcE,RII/CD23): a point of contact between the effector phase of allergy and B cell differentiation; Different mast cell mediators produced by different mast cell phenotypes; Mast cells: immunologically specific effectors and potential sources of multiple cytokines during IgE-dependent responses; Non-IgE-mediated mast cell stimulation; The receptor with high affinity for IgE 327 $aCalcium: an important second messenger in mast cellsLow affinity IgE receptors: regulation and functional roles in cell activation; IgE and inflammatory cells; Molecular genetics of human responsiveness to allergens; Influence of environmental factors on IgE production; Epidemiology of the allergic response; Heterogeneity of human FcERI-bearing cells; Conventional and new approaches to hyposensitization; Final general discussion; Closing statement; Index of contributors; Subject index 330 $aReviews recent basic research into IgE, mast cells, and the allergic response and the relevance of this work to human pathophysiology, and discusses new methods of treatment. This symposium is unique in the IgE field for its breadth of coverage and interdisciplinary nature, and it shows the benefits from the current rapid expansion of knowledge in cell biology, immunology, and molecular genetics, as well as the potential clinical significance of this research to clinical immunologists and allergologists. 410 0$aCiba Foundation symposium ;$v147. 606 $aImmunoglobulin E$vCongresses 606 $aMast cells$xImmunology$vCongresses 606 $aAllergy$xPathogenesis$vCongresses 615 0$aImmunoglobulin E 615 0$aMast cells$xImmunology 615 0$aAllergy$xPathogenesis 676 $a616.07/9 701 $aChadwick$b Derek$091632 712 12$aSymposium on IgE, Mast Cells and the Allergic Response$f(1989 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019930003321 996 $aIgE, mast cells, and the allergic response$94419471 997 $aUNINA