LEADER 04006nam 2200685 a 450 001 9911019919503321 005 20200520144314.0 010 $a9786612347955 010 $a9781282347953 010 $a1282347950 010 $a9780470514887 010 $a0470514884 010 $a9780470514894 010 $a0470514892 035 $a(CKB)1000000000377140 035 $a(EBL)470488 035 $a(OCoLC)609849414 035 $a(SSID)ssj0000312621 035 $a(PQKBManifestationID)11925261 035 $a(PQKBTitleCode)TC0000312621 035 $a(PQKBWorkID)10350483 035 $a(PQKB)10451708 035 $a(MiAaPQ)EBC470488 035 $a(Perlego)2788239 035 $a(EXLCZ)991000000000377140 100 $a19951228d1996 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aVariation in the human genome /$f[editors, Derek Chadwick and Gail Cardew] 210 $aChichester ;$aNew York $cWiley$d1996 215 $a1 online resource (341 p.) 225 1 $aCiba Foundation symposium ;$v197 300 $aSymposium on Variation in the Human Genome, held at the Ciba Foundation, London, 15 June 1995. 311 08$a9780471961529 311 08$a0471961523 327 $aVARIATION IN THE HUMAN GENOME; Contents; Participants; Introduction; Phylogeographic variability in traditional societies; Interpreting genetic variabiIity: the effects of shared evolutionary history; Microsatellites: evolution and mutational processes; The phenylalanine hydroxylase locus: a marker for the history of phenylketonuria and human genetic diversity; Genetic and geographical variability in cystic fibrosis: evolutionary considerations; Unusual inheritance patterns due to dynamic mutation in fragile X syndrome 327 $aControl of b-thalassaemia by carrier screening, genetic counselling and prenatal diagnosis: the Sardinian experienceMultigenic control of skin tumour development in mice1; Population genetics of tumours; Genetic factors that contribute to interindividual variations in plasma low density lipoprotein-cholesterol levels1; Genetic architecture of common mu Itifactorial diseases; World distribution of HLA alleles and implications for disease 327 $aCladistic approaches to identifying determinants of variability in multifactorial phenotypes and tt e evolutionary significance of variation in the human genomeQuantitative phenotype analysis for localization and identification of disease-related genes in a complex genetic background; The genetics of common diseases: the implications of population variability; Final discussion; Summary; Index of contributors; Subject index 330 $aThe mapping of human genes is proceeding rapidly. Genes associated with specific inherited diseases are being identified, often providing insight into the molecular cause of the disease. At the moment, however, little consideration is being given to the variation present in different human populations. Variation in the Human Genome discusses methods of analysing population genetic data and how contemporary genetic heterogeneity arises during the evolution and migration of human populations. Specific disorders such as cystic fibrosis, beta-thalassaemia, fragile X, phenylketonuria and tumour dev 410 0$aCiba Foundation symposium ;$v197. 606 $aHuman population genetics$vCongresses 606 $aHuman genome$vCongresses 606 $aHuman genetics$xVariation$vCongresses 615 0$aHuman population genetics 615 0$aHuman genome 615 0$aHuman genetics$xVariation 676 $a573.2/1 701 $aChadwick$b Derek$091632 701 $aCardew$b Gail$0857118 712 12$aSymposium on Variation in the Human Genome$f(1995 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019919503321 996 $aVariation in the human genome$94421490 997 $aUNINA