LEADER 05295nam 2200661Ia 450 001 9911019880703321 005 20200520144314.0 010 $a9786610854332 010 $a9781280854330 010 $a1280854332 010 $a9783527608034 010 $a3527608036 010 $a9783527607365 010 $a3527607366 035 $a(CKB)1000000000377172 035 $a(EBL)482336 035 $a(OCoLC)70159059 035 $a(SSID)ssj0000261262 035 $a(PQKBManifestationID)11206105 035 $a(PQKBTitleCode)TC0000261262 035 $a(PQKBWorkID)10255485 035 $a(PQKB)10374377 035 $a(MiAaPQ)EBC482336 035 $a(Perlego)2786648 035 $a(EXLCZ)991000000000377172 100 $a20050106d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTranscription factors in the nervous system $edevelopment, brain function and diseases /$fedited by Gerald Thiel 210 $aWeinheim $cWiley-VCH$dc2006 215 $a1 online resource (507 p.) 300 $aDescription based upon print version of record. 311 08$a9783527312856 311 08$a3527312854 320 $aIncludes bibliographical references and index. 327 $aTranscription Factors in the Nervous System; Contents; Preface; List of Contributors; Color Plates; Part I Transcription Factors in Neural Development; 1 Roles of Hes bHLH Factors in Neural Development; 1.1 Introduction; 1.2 Structure and Transcriptional Activities of Hes Factors; 1.3 Regulation of Hes Gene Expression; 1.4 Expression of Hes Genes in the Developing Nervous System; 1.5 Maintenance of Neural Stem Cells by Hes Genes; 1.6 Promotion of Gliogenesis by Hes Genes; 1.7 Maintenance of the Isthmic Organizer by Hes Genes; 1.8 Perspective; Acknowledgments; Abbreviations 327 $a2 The Role of Pax6 in the Nervous System during Development and in Adulthood: Master Control Regulator or Modular Function?Abstract; 2.1 Introduction; 2.2 Molecular Features of Pax6; 2.2.1 The Paired Domain; 2.2.2 The Paired-Type Homeodomain; 2.2.3 Different Pax6 Isoforms; 2.2.4 Protein-Protein Interactions; 2.2.5 Post-Translational Modifications of Pax6; 2.3 Function of Pax6 in Development; 2.3.1 Function of Pax6 in the Developing Eye; 2.3.2 Function of Pax6 in the Developing Brain; 2.3.2.1 Telencephalon; 2.3.2.2 Diencephalon; 2.3.2.3 Cerebellum; 2.3.2.4 Spinal Cord 327 $a2.4 Function of Pax6 in the Adult Brain2.5 Mechanisms of Pax6 Function; 2.6 Conclusions and Outlook; Abbreviations; 3 Phox2a and Phox2b: Essential Transcription Factors for Neuron Specification and Differentiation; Abstract; 3.1 Introduction; 3.2 Molecular Characteristics of Phox2 Genes and Proteins; 3.2.1 Sequence and Gene Structure Conservation in the Animal Kingdom; 3.2.2 Transcriptional Activation by Phox2 Proteins; 3.3 Physiological Relevance of Phox2 Transcription Factors; 3.3.1 Expression Pattern; 3.3.2 Effects of Phox2 Gene Mutations 327 $a3.3.2.1 Autonomic Neural Crest Derivatives and Visceral Sensory Ganglia3.3.2.2 Central Noradrenergic Neurons; 3.3.2.3 Autonomic Centers in the Hindbrain; 3.3.3 Human Mutations; 3.4 Molecular Mechanism of Action in Different Lineages; 3.4.1 Sympathetic Neurons; 3.4.2 Parasympathetic Neurons; 3.4.3 Enteric Neurons; 3.4.4 Visceral Sensory Neurons of the Geniculate, Petrosal and Nodose Ganglia; 3.4.5 Central Noradrenergic Neurons; 3.4.6 Autonomic Centers in the Hindbrain; 3.4.6.1 Afferent Visceral Centers; 3.4.6.2 Efferent Visceral Centers; 3.4.7 Oculomotor (nIII) and Trochlear (nIV) Centers 327 $a3.5 Conclusions and Outlook3.5.1 Distinct or Identical Functions for Phox2a and Phox2b?; 3.5.2 Master Control Genes for Noradrenergic Differentiation; 3.5.3 Master Control Genes for Autonomic Reflex Circuit Generation; Acknowledgments; Abbreviations; 4 Functions of LIM-Homeodomain Proteins in the Development of the Nervous System; Abstract; 4.1 Introduction; 4.2 Common Structural Features and Classification of LIM-HD Proteins; 4.3 LIM-HD Proteins and the Development of Invertebrate Nervous Systems; 4.3.1 C. elegans; 4.3.2 Drosophila 327 $a4.4 Functions of LIM-HD Proteins in the Development of Vertebrate Nervous Systems 330 $aThis first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases.With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, ne 606 $aTranscription factors 606 $aNeural stem cells 615 0$aTranscription factors. 615 0$aNeural stem cells. 676 $a616.8042 701 $aThiel$b Gerald$01840526 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019880703321 996 $aTranscription factors in the nervous system$94420094 997 $aUNINA