LEADER 01003nam a2200253 i 4500 001 991003281879707536 008 160921s1974 sp b 000 0 spa d 020 $a8450065011 035 $ab14308447-39ule_inst 040 $aDip. di Studi Umanistici$bita 100 1 $aBerenguer Carisomo, Arturo$0192883 245 13$aLa Prosa de Bécquer /$cArturo Berenguer Carisomo 250 $a2. ed. corr. y aum. 260 $aSevilla :$bUniversidad de Sevilla,$c1974 300 $a142 p. ;$c19 cm 440 0$aPublicaciones de la Universidad de Sevilla. Colección de bolsillo ;$v30 504 $aContiene riferimenti bibliografici 600 14$aBécquer, Gustavo Adolfo$d<1836-1870>$xOpere in prosa. 907 $a.b14308447$b21-09-16$c21-09-16 912 $a991003281879707536 945 $aLE012 868.5 BEC BER$g1$i2007000275627$lle012$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i15781641$z21-09-16 996 $aProsa de Bécquer$91392544 997 $aUNISALENTO 998 $ale012$b21-09-16$cm$da $e-$fspa$gsp $h3$i0 LEADER 04526oam 2201105zu 450 001 9911019870603321 005 20260206214406.0 010 $a1-280-55673-0 010 $a9786610556731 010 $a0-471-65615-1 010 $a0-471-65616-X 035 $a(CKB)1000000000019046 035 $a(SSID)ssj0000303502 035 $a(PQKBManifestationID)11212041 035 $a(PQKBTitleCode)TC0000303502 035 $a(PQKBWorkID)10275576 035 $a(PQKB)10119555 035 $a(MiAaPQ)EBC4957569 035 $a(Au-PeEL)EBL4957569 035 $a(CaONFJC)MIL55673 035 $a(OCoLC)1024283262 035 $a(EXLCZ)991000000000019046 100 $a20160829d2004 uy 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular cancer therapeutics : strategies for drug discovery and development 210 31$a[Place of publication not identified]$cWiley Liss$d2004 215 $a1 online resource (362 pages) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a0-471-43202-4 330 $aMolecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer.; Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns. 606 $aCancer$xChemotherapy 606 $aCancer$xImmunotherapy 606 $aAntineoplastic agents$xDevelopment 606 $aPharmacogenetics 606 $aAntineoplastic Agents 606 $aDrug Delivery Systems 606 $aDrug Evaluation 606 $aNeoplasms 606 $aDrug Therapy 606 $aEvaluation Studies as Topic 606 $aTherapeutic Uses 606 $aDisease 606 $aPharmacology 606 $aGenetics 606 $aInvestigative Techniques 606 $aPharmacologic Actions 606 $aTherapeutics 606 $aBiology 606 $aHealth Occupations 606 $aBiological Science Disciplines 606 $aChemical Actions and Uses 606 $aDiagnostic Techniques and Procedures 606 $aNatural Science Disciplines 606 $aOccupations 606 $aOncology$2HILCC 606 $aMedicine$2HILCC 606 $aHealth & Biological Sciences$2HILCC 615 0$aCancer$xChemotherapy. 615 0$aCancer$xImmunotherapy. 615 0$aAntineoplastic agents$xDevelopment. 615 2$aPharmacogenetics. 615 2$aAntineoplastic Agents. 615 2$aDrug Delivery Systems. 615 2$aDrug Evaluation. 615 2$aNeoplasms. 615 2$aDrug Therapy. 615 2$aEvaluation Studies as Topic. 615 2$aTherapeutic Uses. 615 2$aDisease. 615 2$aPharmacology. 615 2$aGenetics. 615 2$aInvestigative Techniques. 615 2$aPharmacologic Actions. 615 2$aTherapeutics. 615 2$aBiology. 615 2$aHealth Occupations. 615 2$aBiological Science Disciplines. 615 2$aChemical Actions and Uses. 615 2$aDiagnostic Techniques and Procedures. 615 2$aNatural Science Disciplines. 615 2$aOccupations. 615 7$aOncology 615 7$aMedicine 615 7$aHealth & Biological Sciences 676 $a616.99/4061 702 $aPrendergast$b George C. 801 0$bPQKB 906 $aBOOK 912 $a9911019870603321 996 $aMolecular cancer therapeutics : strategies for drug discovery and development$94420653 997 $aUNINA