LEADER 05217nam 2200721Ia 450 001 9911019862703321 005 20200520144314.0 010 $a9786612301575 010 $a9781282301573 010 $a1282301578 010 $a9780470186756 010 $a0470186755 010 $a9780470188255 010 $a0470188251 035 $a(CKB)1000000000376533 035 $a(EBL)469258 035 $a(OCoLC)609847959 035 $a(SSID)ssj0000388132 035 $a(PQKBManifestationID)11286739 035 $a(PQKBTitleCode)TC0000388132 035 $a(PQKBWorkID)10411196 035 $a(PQKB)10535660 035 $a(MiAaPQ)EBC469258 035 $a(Perlego)2785628 035 $a(EXLCZ)991000000000376533 100 $a20070727d1962 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe pyrimidines /$fD.J. Brown ; with an essay by S.F. Mason 205 $a99th ed. 210 $aNew York $cInterscience$d1962 215 $a1 online resource (803 p.) 225 1 $aChemistry of heterocyclic compounds ;$v. 60 300 $aDescription based upon print version of record. 311 08$a9780470381151 311 08$a0470381159 320 $aIncludes bibliographical references and index. 327 $aTHE PYRIMIDINES; Contents; Chapter I. Introduction to the Pyrimidines; 1.History; 2 . Nomenclature; 3 . The Unique Basis of Pyrimidine Chemistry; A . The "Active" 2-,4-, and 6-Positions; B . The "Aromatic" 5-Position; C . The Effect of Electron-releasing Groups; D . The Effect of Electron-withdrawing Groups; E . Tautomeric Groups; 4 . General Summary of Pyrimidine Chemistry; A . Electrophilic Substitution; (1) Nitration and Nitrosation; (2) Diazo Coupling; (3) Halogenation; (4) Sulphonation; (5) Attack by Chloroform or Chloral; (6) Other Electrophilic Attacks 327 $aB . Direct Nucleophilic SubstitutionC . Nucleophilic Metatheses; (1) Replacement of Halogens; (a) By Amino and Substituted-amino Groups; (b) By Methoxy and Similar Groups; (c) By Hydroxy Groups; (d) By Methylthio and Related Groups; (e) By Mercapto Groups; (f) By Sulpho and Thiocyanato Groups; (2) Replacement of Methoxy, Methylthio. and Methylsulphonyl Groups; D . Other Metatheses; (1) Hydroxy- to Chloro-pyrimidines; (2) Hydroxy- to Mercapto-pyrimidines; (3) Mercapto- to Hydroxy-pyrimidines; (4) Mercapto- to Amino-pyrimidines; (5) Amino- to Hydroxy-pyrimidines 327 $a(6) Amino- to Chloro-pyrimidines(7) Replacements of Quaternary Amino Groups; E . Addition Reactions; (1) Quaternization; (2) Formation of N-Oxides; (3) Addition of Hypobromous Acid; (4) Addition of Water; (5) Addition of Grignard Reagents and Lithium Alkyls; F . Oxidative Reactions; G . Reductive Reactions; (1) Nuclear Reduction; (2) Reductive Removal of Groups; (3) Reductive Modification of Groups; H . The Modification of Substituents; (1) Amino Groups; (2) Hydroxy Groups; (3) Mercapto Groups; (4) Methyl Groups; I . A Free Radical Reaction; 5 . Physical Properties of Pyrimidines 327 $aA . Electronic StructuresB . Ionization Constants; C . Spectra; D . Dipole Moments; E . Polarography; F . Solubility and Melting Point; Chapter II . The Principal Synthetic Method; 1 . General Scope; 2 . Use of B-Dialdehydes; 3 . Use of B-Aldehydo Ketones; 4 . Use of B-Diketones; 5 . Use of B-Aldehydo Esters; A . Aldehydo Esters with Thioureas; B . The Davidson-Baudisch Synthesis; C . The Use of a-Ethoxymethylene Esters; 6 . Use of B-Keto Esters; A . Keto Esters with Thioureas; B . Keto Esters with Amidines; C . Keto Esters with Guanidines; D . Keto Esters with Urea and Derivatives 327 $a7 . Use of B-Diesters (Malonic Esters)A . Malonic Esters and Amidines; B . Malonic Esters with Urea and its Alkyl Derivatives; C . Malonic Esters with Thiourea and Derivatives; D . Malonic Esters with Guanidine and its Alkyl Derivatives; 8 . Use of B-Aldehydo Nitriles; A . Aldehydo Nitriles with Ureas; B . Aldehydo NitriIes with Thioureas; C . Aldehydo Nitriles with Amidines; D . The Whitehead Synthesis of Cytosine Derivatives; E . Aldehydo Nitriles with Guanidine; 9 . Use of B-Keto Nitriles; 10 . Use of B-Ester Nitriles; A . Ester Nitriles with Amidines 327 $aB . Ester Nitriles with Urea and Alkyl Ureas 330 $aChemistry of Heterocyclic Compounds publishes articles, letters to the Editor, reviews, and minireviews on the synthesis, structure, reactivity, and biological activity of heterocyclic compounds including natural products. The journal covers investigations in heterocyclic chemistry taking place in scientific centers of all over the world, including extensively the scientific institutions in Russia, Ukraine, Latvia, Lithuania and Belarus. 410 0$aChemistry of heterocyclic compounds ;$v. 60. 606 $aPyrimidines 606 $aChemistry 615 0$aPyrimidines. 615 0$aChemistry. 676 $a547.593 676 $a547/.59/05 676 $a547/.593 700 $aBrown$b D. J$0383088 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019862703321 996 $aThe pyrimidines$91996097 997 $aUNINA