LEADER 03947nam 2200685Ia 450 001 9911019825503321 005 20200520144314.0 010 $a9786610900824 010 $a9781280900822 010 $a1280900822 010 $a9780470319390 010 $a0470319399 010 $a9780470319406 010 $a0470319402 035 $a(CKB)1000000000357042 035 $a(EBL)297464 035 $a(SSID)ssj0000259603 035 $a(PQKBManifestationID)11244615 035 $a(PQKBTitleCode)TC0000259603 035 $a(PQKBWorkID)10186298 035 $a(PQKB)11770170 035 $a(MiAaPQ)EBC297464 035 $a(OCoLC)181345961 035 $a(PPN)250337878 035 $a(Perlego)2786370 035 $a(EXLCZ)991000000000357042 100 $a20061121d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTinkering $ethe microevolution of development /$f[editors: Gregory Bock and Jamie Goode] 210 $aChichester ;$aHoboken, NJ $cJohn Wiley & Sons$d2007 215 $a1 online resource (301 p.) 225 1 $aNovartis Foundation symposium ;$v284 300 $aDescription based upon print version of record. 311 08$a9780470034293 311 08$a0470034297 320 $aIncludes bibliographical references and indexes. 327 $aTinkering: The Microevolution of Development; Contents; The evolutionary developmental biology of tinkering: an introduction to the challenge; Tinkering: a conceptual and historical evaluation; DISCUSSION; Tinkering: new embryos from old-rapidly and cheaply; DISCUSSION; The relationship between development and evolution through heritable variation; DISCUSSION; Genetic networks as transmitting and amplifying devices for natural genetic tinkering; DISCUSSION; Butterfly eyespot patterns and how evolutionary tinkering yields diversity; DISCUSSION; GENERAL DISCUSSION I 327 $aTinkering with transcription factor proteins: the role of transcription factor adaptation in developmental evolutionDISCUSSION; Tinkering with constraints in the evolution of the vertebrate limb anterior-posterior polarity; DISCUSSION; Affecting tooth morphology and renewal by fine-tuning the signals mediating cell and tissue interactions; DISCUSSION; GENERAL DISCUSSION II; Evolution of covariance in the mammalian skull; DISCUSSION; The developmental genetics of microevolution; DISCUSSION; The economy of tinkering mammalian teeth; DISCUSSION 327 $aPelvic skeleton reduction and Pitx1 expression in threespine stickleback populationsDISCUSSION; Using patterns of fin and limb phylogeny to test developmental- evolutionary scenarios; DISCUSSION; Craniofacial variation and developmental divergence in primate and human evolution; DISCUSSION; Contributor Index; Subject Index 330 $aMuch recent research in evolutionary developmental biology has focused on the origin of new body plans. However, most evolutionary change at the population and species level consists of tinkering: small-scale alterations in developmental pathways within a single body plan. Such microevolutionary events have been well studied on a population genetic level and from the perspective of adaptive phenotypic evolution, but their developmental mechanisms remain poorly studied. This book explores both theoretical and practical issues of tinkering. It features a wide range of perspectives to addres 410 0$aNovartis Foundation symposium ;$v284. 606 $aMolecular biology 606 $aMolecular evolution 615 0$aMolecular biology. 615 0$aMolecular evolution. 676 $a572.8 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019825503321 996 $aTinkering$94421093 997 $aUNINA