LEADER 03848nam 22006134a 450 001 9911019762003321 005 20200520144314.0 010 $a9786610276578 010 $a9781280276576 010 $a1280276576 010 $a9780471716716 010 $a0471716715 010 $a9780471716709 010 $a0471716707 035 $a(CKB)1000000000355465 035 $a(SSID)ssj0000104284 035 $a(PQKBManifestationID)11133453 035 $a(PQKBTitleCode)TC0000104284 035 $a(PQKBWorkID)10078533 035 $a(PQKB)10699924 035 $a(MiAaPQ)EBC238506 035 $a(Perlego)2750844 035 $a(EXLCZ)991000000000355465 100 $a20040820d2005 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAntiviral drug discovery for emerging diseases and bioterrorism threats /$fedited by Paul F. Torrence 210 $aHoboken, N.J. $cWiley-Interscience$dc2005 215 $ax, 420 p. $cill 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a9780471668275 311 08$a0471668273 320 $aIncludes bibliographical references and index. 327 $aViral bioterrorism and antiviral countermeasures / M. Bray -- Research on emerging and bioterror threats / C. Tseng -- Antiviral drug targets and strategies for emerging viral diseases and bioterrorism threats / E. de Clercq -- Perspectives for the therapy against arenavirus infections / E.B. Damonte, C.C. Garcia -- S-adenosylhomocysteine hydrolase inhibitors as a source of anti-filovirus agents / S.W. Schneller, M. Yang -- Antiviral strategies for Ebola virus / R.N. Harty and J. M. Licata -- IMPDH inhibitors : discovery of antiviral agents against emerging diseases / V. Nair -- Lethal mutagenesis : exploiting error-prone replication of riboviruses for -- Antiviral therapy / J.D. Graci, C.E. Cameron -- Structural biology of flavivral replications and opportunities for drug design / K. Murthy -- Confronting new and old antiviral threats : broad spectrum potential of prenylation inhibitors / M. Elazar, J.S. Glenn -- 327 $aThe discovery and development of new antivirals for smallpox / E.R. Kern -- Prevention of viral infection by immunocamouflage of target tissues / L. McCoy, M.D. Scott -- Viral evasion of the interferon system : novel targets for drug discovery / L. Powell, P.F. Torrence -- The emergence of pandemic influenza : bioterrorist vs. mother nature / J. S. Oxford, A. Catchpole, R. Lambkin -- Novel approach to smallpox (variola) inhibitors / A. Rich, B. Jacobs -- Structure-based design of anti-SARS drug / R. Hilgenfeld. 330 8 $aAntiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents. 606 $aAntiviral agents 606 $aDrug development 606 $aBioterrorism 615 0$aAntiviral agents. 615 0$aDrug development. 615 0$aBioterrorism. 676 $a616.9/1061 701 $aTorrence$b Paul F$01837821 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019762003321 996 $aAntiviral drug discovery for emerging diseases and bioterrorism threats$94422349 997 $aUNINA