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010   $a9786610556113
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100   $a20160829d2001      uy 
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt
182   $cc
183   $acr
200 14$aThe tumour microenvironment : causes and consequences of hypoxia and acidity
210 31$a[Place of publication not identified]$cWiley$d2001
215   $a1 online resource (312 pages)
225 1 $aNovartis Foundation Symposia ;$vv.205
300   $aBibliographic Level Mode of Issuance: Monograph
311 08$a0-471-49959-5 
311 08$a0-470-86870-8 
330   $aIn recent years, there has been great interest in exploiting the hypoxic tumour microenvironment for therapeutic gain. It has also become clear that this microenvironment is acidic and thus hostile to the growth and survival of viable normal cells. These observations lead to several fundamentally important questions that form the basis for this book. What are the relationships between tumour perfusion and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? This exciting book brings together leading clinicians and researchers to address some of these key issues. It is hypothesized that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Therapeutic strategies taking into account the consequences of altered pH, or which seek to manipulate tumour pH, more be more effective than those currently employed.
410  0$aNovartis Foundation Symposia
606   $aCell Hypoxia
606   $aNeoplasm Invasiveness
606   $aHydrogen-Ion Concentration
606   $aNeoplasm Metastasis
606   $aNeoplasms
606   $aChemical Phenomena
606   $aNeoplastic Processes
606   $aDisease
606   $aCell Respiration
606   $aMetabolism
606   $aPathologic Processes
606   $aPathological Conditions, Signs and Symptoms
606   $aCell Physiological Phenomena
606   $aOncology$2HILCC
606   $aMedicine$2HILCC
606   $aHealth & Biological Sciences$2HILCC
615  2$aCell Hypoxia.
615  2$aNeoplasm Invasiveness.
615  2$aHydrogen-Ion Concentration.
615  2$aNeoplasm Metastasis.
615  2$aNeoplasms.
615  2$aChemical Phenomena.
615  2$aNeoplastic Processes.
615  2$aDisease.
615  2$aCell Respiration.
615  2$aMetabolism.
615  2$aPathologic Processes.
615  2$aPathological Conditions, Signs and Symptoms.
615  2$aCell Physiological Phenomena.
615  7$aOncology
615  7$aMedicine
615  7$aHealth & Biological Sciences
676   $a616.992
702   $aChadwick$b Derek
702   $aGoode$b Jamie
712 02$aNovartis Foundation.
712 12$aSymposium on the Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity$f(2000 :$eLondon, England)
801  0$bPQKB
906   $aBOOK
912   $a9911019753103321
996   $aThe tumour microenvironment : causes and consequences of hypoxia and acidity$94419084
997   $aUNINA