LEADER 05092nam 2200733z 450 001 9911019719403321 005 20230830173756.0 010 $a9786610366798 010 $a9781280366796 010 $a1280366796 010 $a9780470305560 010 $a0470305568 010 $a9781601195159 010 $a160119515X 010 $a9780471234920 010 $a0471234923 035 $a(CKB)111056485566910 035 $a(EBL)152097 035 $a(OCoLC)475871925 035 $a(SSID)ssj0000073111 035 $a(PQKBManifestationID)11107288 035 $a(PQKBTitleCode)TC0000073111 035 $a(PQKBWorkID)10102907 035 $a(PQKB)10097389 035 $a(MiAaPQ)EBC152097 035 $a(JP-MeL)3000111451 035 $a(NjHacI)99111056485566910 035 $a(Perlego)2786220 035 $a(EXLCZ)99111056485566910 100 $a20220719d ||| || 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aThermodynamics of Pharmaceutical Systems $eAn Introduction for Students of Pharmacy /$fConnorsKennethA.? 210 $c??????????????????????????????$d2002.9 210 1$aHoboken, New Jersey :$cWiley-Interscience,$d2002. 215 $a1 online resource (358 p.) 300 $aDescription based upon print version of record. 311 08$a9780471461395 311 08$a0471461393 311 08$a9780471202417 311 08$a047120241X 320 $aIncludes bibliographical references (p. 333-335) and index. 327 $aTHERMODYNAMICS OF PHARMACEUTICAL SYSTEMS; CONTENTS; PREFACE; I BASIC THERMODYNAMICS; 1 Energy and the First Law of Thermodynamics; 1.1. Fundamental Concepts; 1.2. The First Law of Thermodynamics; 1.3. The Enthalpy; 2 The Entropy Concept; 2.1. The Entropy Defined; 2.2. The Second Law of Thermodynamics; 2.3. Applications of the Entropy Concept; 3 The Free Energy; 3.1. Properties of the Free Energy; 3.2. The Chemical Potential; 4 Equilibrium; 4.1. Conditions for Equilibrium; 4.2. Physical Processes; 4.3. Chemical Equilibrium; II THERMODYNAMICS OF PHYSICAL PROCESSES 327 $a5 Introduction to Physical Processes5.1. Scope; 5.2. Concentration Scales; 5.3. Standard States; 6 Phase Transformations; 6.1. Pure Substances; 6.2. Multicomponent Systems; 7 Solutions of Nonelectrolytes; 7.1. Ideal Solutions; 7.2. Nonideal Solutions; 7.3. Partitioning between Liquid Phases; 8 Solutions of Electrolytes; 8.1. Coulombic Interaction and Ionic Dissociation; 8.2. Mean Ionic Activity and Activity Coefficient; 8.3. The Debye-Hu?ckel Theory; 9 Colligative Properties; 9.1. Boiling Point Elevation; 9.2. Freezing Point Depression; 9.3. Osmotic Pressure; 9.4. Isotonicity Calculations 327 $a10 Solubility10.1. Solubility as an Equilibrium Constant; 10.2. The Ideal Solubility; 10.3. Temperature Dependence of the Solubility; 10.4. Solubility of Slightly Soluble Salts; 10.5. Solubilities of Nonelectrolytes: Further Issues; 11 Surfaces and Interfaces; 11.1. Thermodynamic Properties; 11.2. Adsorption; III THERMODYNAMICS OF CHEMICAL PROCESSES; 12 Acid-Base Equilibria; 12.1. Acid-Base Theory; 12.2. pH Dependence of Acid-Base Equilibria; 12.3. Calculation of Solution pH; 12.4. Acid-Base Titrations; 12.5. Aqueous Solubility of Weak Acids and Bases; 12.6. Nonaqueous Acid-Base Behavior 327 $a12.7. Acid-Base Structure and Strength13 Electrical Work; 13.1. Introduction; 13.2. Oxidation-Reduction Reactions; 13.3. Electrochemical Cells; 13.4. pH Measurement; 13.5. Ion-Selective Membrane Electrodes; 14 Noncovalent Binding Equilibria; 14.1. Introduction; 14.2. The Noncovalent Interactions; 14.3. Binding Models; 14.4. Measurement of Binding Constants; APPENDIXES; A Physical Constants; B Review of Mathematics; B.1. Introduction; B.2. Logarithms and Exponents; B.3. Algebraic and Graphical Analysis; B.4. Dealing with Change; B.5. Statistical Treatment of Data; B.6. Dimensions and Units 327 $aANSWERS TO PROBLEMSBIBLIOGRAPHY; INDEX 330 $aStudies of thermodynamics often fail to demonstrate how the mathematical intricacies of the subject relate to practical laboratory applications. Thermodynamics of Pharmaceutical Systems makes these connections clear, emphasizing specific applications to pharmaceutical systems in a study created specifically for contemporary curriculums at colleges of pharmacy. Students investigating drug discovery, drug delivery, and drug action will benefit from Kenneth Connors's authoritative treatment of the fundamentals of thermodynamics as well as his attention to drug molecules and experimental conside 606 $aPharmaceutical chemistry 606 $aThermodynamics 615 0$aPharmaceutical chemistry. 615 0$aThermodynamics. 676 $a615.19 676 $a615/.19 686 $a499.3$2njb/09 686 $aQC 311$2njb/09 686 $a615/.19$2njb/09 801 1$bJP-MeL 906 $aBOOK 912 $a9911019719403321 996 $aThermodynamics of Pharmaceutical Systems$94420967 997 $aUNINA