LEADER 04133nam 2200721 a 450 001 9911019696103321 005 20200520144314.0 010 $a9786612347771 010 $a9781282347779 010 $a1282347772 010 $a9780470514221 010 $a0470514221 010 $a9780470514238 010 $a047051423X 035 $a(CKB)1000000000377136 035 $a(EBL)470637 035 $a(OCoLC)609849624 035 $a(SSID)ssj0000306544 035 $a(PQKBManifestationID)11230110 035 $a(PQKBTitleCode)TC0000306544 035 $a(PQKBWorkID)10299133 035 $a(PQKB)10017870 035 $a(MiAaPQ)EBC470637 035 $a(Perlego)2773226 035 $a(EXLCZ)991000000000377136 100 $a19920109d1992 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPostimplantation development in the mouse 210 $aChichester ;$aNew York $cWiley$d1992 215 $a1 online resource (332 p.) 225 1 $aCiba Foundation symposium ;$v165 300 $aEditors, Derek J. Chadwick and Joan Marsh. 300 $a"A Wiley-Interscience publication." 311 08$a9780471933847 311 08$a0471933848 320 $aIncludes bibliographical references and indexes. 327 $aPOSTIMPLANTATION DEVELOPMENT IN THE MOUSE; Contents; Introduction; Clonal analysis of cell fate during gastrulation and early neurulation in the mouse; Establishment and organization of germ layers in the gastrulating mouse embryo; General discussion I : Problems with cell markers and embryo cultures; Three-dimensional representation of gastrulation in the mouse; Use of chimeras to study gene function in mesodermal tissues during gastrulation and early organogenesis; Action of the Brachyury gene in mouse embryogenesis; Molecular mechanisms of pattern formation in the vertebrate hindbrain 327 $aGeneral discussion II : Developmental abnormalities in tetraploid mouse embryosMyogenesis in the mouse; Development of the skeletal system; Development of the Ieft-right axis; The role of Sry in mammalian sex determination; Epithelial-mesenchymal interactions in murine organogenesis; The Wnt family of cell signalling molecules in postimplantation development of the mouse; The TGF-B-related DVR family in mammalian development; General discussion III Compiling information on developmental gene expression 327 $aUse of embryonic stem cells to study mutations affecting postimplantation development in the mouseGenetic manipulation of the mouse via gene targeting in embryonic stem cells; The gene trap approach in embryonic stem cells: the potential for genetic screens in mice; Final discussion : Functional redundancy; When does an embryo become a fetus?; Summary; Author index; Subject index 330 $aExamines the establishment of the germ layers and other cell lineages in the early embryo including details of cell movements during the beginning stages of primitive streak formation. Discusses patterns of gene expression during the development of such tissues as the limb bud, skeletal, muscle and the central nervous systems placing special emphasis on commitment to particular cell types. Although it concentrates on the mouse as an example of mammalian development--chick, amphibian and Drosophila embryogenesis are employed whenever these organisms are more applicable to the study of a particu 410 0$aCiba Foundation symposium ;$v165. 606 $aMice$xEmbryos$vCongresses 606 $aMice$xDevelopment$vCongresses 606 $aDevelopmental cytology$vCongresses 606 $aMice$xEmbryos$xPhysiology$vCongresses 615 0$aMice$xEmbryos 615 0$aMice$xDevelopment 615 0$aDevelopmental cytology 615 0$aMice$xEmbryos$xPhysiology 676 $a599.32/33 701 $aChadwick$b Derek$091632 701 $aMarsh$b Joan$091633 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019696103321 996 $aPostimplantation development in the mouse$94422435 997 $aUNINA