LEADER 04364nam 2200721 a 450 001 9911019694503321 005 20200520144314.0 010 $a9786612347672 010 $a9781282347670 010 $a1282347675 010 $a9780470513989 010 $a0470513985 010 $a9780470513996 010 $a0470513993 035 $a(CKB)1000000000377205 035 $a(EBL)470472 035 $a(SSID)ssj0000310375 035 $a(PQKBManifestationID)11229913 035 $a(PQKBTitleCode)TC0000310375 035 $a(PQKBWorkID)10287324 035 $a(PQKB)11025675 035 $a(MiAaPQ)EBC470472 035 $a(OCoLC)181173156 035 $a(Perlego)2776106 035 $a(EXLCZ)991000000000377205 100 $a19900626d1990 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSteroids and neuronal activity 210 $aChichester, West Sussex, England ;$aNew York $cWiley$d1990 215 $a1 online resource (296 p.) 225 1 $aCiba Foundation symposium ;$v153 300 $a"Symposium on Steroids and Neuronal Activity, held at the Ciba Foundation, London, 23-25 January 1990"--P. v. 300 $a"A Wiley-Interscience publication." 300 $aEditors: Derek Chadwick, organizer, and Kate Widdows. 311 08$a9780471926894 311 08$a0471926892 320 $aIncludes bibliographical references and indexes. 327 $aSTEROIDS AND NEURONAL ACTIVITY; Contents; Introduction; Steroid effects on neuronal activity: when is the genome involved?; Neuroendocrine metabolism of progesterone and related progestins; Steroid modulation of the GABAA receptor complex: electrophysiological studies; Steroid regulation of the GABAA receptor: ligand binding, chloride transport and behaviour; Steroid binding at si receptors: CNS and immunological implications; General discussion I : Gene-mediated corticosteroid effects on neuronal excitability; Effects of progesterone and its metabolites on neuronal membranes 327 $aIn vitro effects of 17B-oestradiol on the sensitivity of receptors coupled to adenylate cyclase on striatal neurons in primary cultureEffect of oestradiol on dopamine receptors and protein kinase C activity in the rat pituitary: binding of oestradiol to pituitary membranes; The molecular features of membrane perturbation by anaesthetic steroids: a study using differential scanning calorimetry, small angle X-ray diffraction and solid state 2H NMR; Effects of prostaglandin E2 and progesterone on rat brain synaptosomal plasma membranes; Steroids and neuronal destruction or stabilization 327 $aGeneral discussion II : Sex differences in GABA-mediated responsesSteroids in relation to epilepsy and anaesthesia; Early and late effects of steroid hormones on the central nervous system; Final general discussion : Use of adrenal corticosteroids in sports; Steroids and anaesthesia; Role of steroids in the brain; Genomic or non-genomic?; Summing-up; Index of contributors; Subject index 330 $aClassical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text deals with recent discoveries showing that steroids can modulate the activity of some neurotransmitters. It explores the role of GABA as an important regulator of neuronal activity in the central nervous system and its inhibitory action as mediated via the GABA receptor and potentiated by steroids. 410 0$aCiba Foundation symposium ;$v153. 606 $aNeuroendocrinology$vCongresses 606 $aSteroid hormones$xPhysiological effect$vCongresses 606 $aNeurons$vCongresses 615 0$aNeuroendocrinology 615 0$aSteroid hormones$xPhysiological effect 615 0$aNeurons 676 $a612.8/14 701 $aChadwick$b Derek$091632 701 $aWiddows$b Kate$01839963 712 12$aSymposium on Steroids and Neuronal Activity$f(1990 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019694503321 996 $aSteroids and neuronal activity$94422428 997 $aUNINA