LEADER 03961nam 2200649 a 450 001 9911019466403321 005 20200520144314.0 010 $a9786613679321 010 $a9781280768552 010 $a128076855X 010 $a9780470719015 010 $a047071901X 010 $a9780470716489 010 $a0470716487 035 $a(CKB)1000000000687271 035 $a(EBL)703747 035 $a(SSID)ssj0000715146 035 $a(PQKBManifestationID)11472746 035 $a(PQKBTitleCode)TC0000715146 035 $a(PQKBWorkID)10700296 035 $a(PQKB)10932788 035 $a(MiAaPQ)EBC703747 035 $a(OCoLC)264621124 035 $a(Perlego)2755328 035 $a(EXLCZ)991000000000687271 100 $a19860103d1957 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCiba Foundation Symposium on the Chemistry and Biology of Purines /$feditors for the Ciba Foundation, G.E.W. Wolstenholme and Cecilia M. O'Connor 210 $aBoston $cLittle, Brown and Co.$d[1957] 215 $a1 online resource (350 p.) 225 1 $aCiba Foundation symposia 300 $aDescription based upon print version of record. 311 08$a9780470722442 311 08$a0470722444 320 $aIncludes bibliographical references and indexes. 327 $aCHEMISTRY AND BIOLOGY OF PURINES; CONTENTS; Opening remarks; Synthesis and properties of purines of potential biological interest; Discussion; Some synthetic studies on purines and related heterocycles; Discussion; Some new -N-methylpurines; The structure of the hydroxypurines investigated by O-and N-methylation; Discussion; The spectra and structure of the monohydroxypurines and other potentially tautomeric purines; Short Communication; The p-electron properties of purine calculated by the L.C.A.O. method; Discussion; The degradation of uric acid by water under pressure 327 $aThe 8-position in purines. The chemical and biological transformation of purines into pteridines Discussion; Cvclonucleosides; Discussion; Stereochemistry of nucleoside synthesis; Discussion; Synthetic chemical investigations related to the metabolism of purines; Discussion; The effects of potential antipurines on a purine-requiring strain of Escherichla coli; Discussion; The chemistry of new purines in the B12 series of vitamins; Biological and microbiological activity of purine analogues of vitamin B12; Discussion; Puromycin; Discussion 327 $aChemical and biological behaviours of 9-b-D-ribofuranosylpurine Discussion; On the activation of the one-carbon unit for the biosynthesis of purine nucleotides; The enzymatic synthesis of inosinic acid de novo; Discussion; Enzymic control of purines by xanthine oxidase; Discussion; The biological effects of 8-azapurines; Discussion; Biochemical effects of 6-mercaptopurine; Discussion; The use of 6-mercaptopurine in the treatment of leukemia; Discussion; General Discussion; Chairman's closing remarks 330 8 $aThe Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. 410 0$aCiba Foundation symposium. 517 3 $aChemistry and biology of purines 606 $aPurines$vCongresses 615 0$aPurines 676 $a612.015 701 $aWolstenholme$b G. E. W$g(Gordon Ethelbert Ward)$063039 701 $aO'Connor$b Cecilia M$g(Cecilia Mary),$f1927-$0207754 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019466403321 996 $aCiba Foundation Symposium on the Chemistry and Biology of Purines$93004934 997 $aUNINA