LEADER 02763nam 2200685 a 450 001 9911019428703321 005 20200520144314.0 010 $a9786613283245 010 $a9783527633494 010 $a3527633499 010 $a9781283283243 010 $a1283283247 010 $a9783527633470 010 $a3527633472 010 $a9783527633487 010 $a3527633480 035 $a(CKB)2550000000054248 035 $a(EBL)700863 035 $a(SSID)ssj0000507332 035 $a(PQKBManifestationID)11303298 035 $a(PQKBTitleCode)TC0000507332 035 $a(PQKBWorkID)10546561 035 $a(PQKB)11749187 035 $a(MiAaPQ)EBC700863 035 $a(OCoLC)729724693 035 $a(Perlego)1011692 035 $a(EXLCZ)992550000000054248 100 $a20111111d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProtein kinases as drug targets /$fedited by Bert Klebl, Gerhard Muller, and Michael Hamacher 205 $a2nd ed. 210 $aWeinheim, Germany $cWiley-VCH$d2011 215 $a1 online resource (398 p.) 225 1 $aMethods and principles in medicinal chemistry ;$vv. 49 300 $aDescription based upon print version of record. 311 08$a9783527317905 311 08$a3527317902 320 $aIncludes bibliographical references and index. 327 $apt. 1. Hit finding and profiling for protein kinases : assay development and screening, libraries -- pt. 2. Medicinal chemistry -- pt. 3. Application of kinase inhibitors to therapeutic indication areas. 330 $aThis timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs.Backed by recent clinical experience with first-generation drugs in the b 410 0$aMethods and principles in medicinal chemistry ;$vv. 49. 606 $aProtein kinases 606 $aDrugs$xDesign 615 0$aProtein kinases. 615 0$aDrugs$xDesign. 676 $a615.19 701 $aMuller$b Gerhard$027342 701 $aKlebl$b Bert$01838711 701 $aHamacher$b Michael$01838712 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019428703321 996 $aProtein kinases as drug targets$94417758 997 $aUNINA