LEADER 03879nam 2200685 a 450 001 9911019402703321 005 20200520144314.0 010 $a9786612347719 010 $a9781282347717 010 $a1282347713 010 $a9780470514085 010 $a0470514086 010 $a9780470514092 010 $a0470514094 035 $a(CKB)1000000000376481 035 $a(EBL)470458 035 $a(SSID)ssj0000298869 035 $a(PQKBManifestationID)11248022 035 $a(PQKBTitleCode)TC0000298869 035 $a(PQKBWorkID)10238418 035 $a(PQKB)10018076 035 $a(MiAaPQ)EBC470458 035 $a(OCoLC)181173059 035 $a(Perlego)2769504 035 $a(EXLCZ)991000000000376481 100 $a19910118d1991 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHost-guest molecular interactions $efrom chemistry to biology 210 $aChichester ;$aNew York $cWiley$d1991 215 $a1 online resource (290 p.) 225 1 $aCiba Foundation symposium ;$v158 300 $aProceedings of the Symposium on Host-Guest Molecular Interactions: from Chemistry to Biology held at the Ciba Foundation, London, Jul. 3-5, 1990. 311 08$a9780471929581 311 08$a0471929581 320 $aIncludes bibliographical references and indexes. 327 $aHOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics 327 $aBinding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index 330 $aComposed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species. Exciting applications are emerging in this field and it is expected that improved understanding of the interactions in synthetic host molecule complexes will lead to a better understanding of the more complex biological systems. Topics include biomimetic chemistry, preorganization, self-assembly, template-directed synthesis, antibiotic binding to peptides and DNA, interactions between prote 410 0$aCiba Foundation symposium ;$v158. 606 $aLigand binding (Biochemistry)$vCongresses 606 $aDrugs$xDesign$vCongresses 606 $aProtein engineering$vCongresses 606 $aProtein binding$vCongresses 615 0$aLigand binding (Biochemistry) 615 0$aDrugs$xDesign 615 0$aProtein engineering 615 0$aProtein binding 676 $a574.19/245 712 12$aSymposium on Host-Guest Molecular Interactions: from Chemistry to Biology$f(1990 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019402703321 996 $aHost-guest molecular interactions$94420704 997 $aUNINA LEADER 06773nam 2200721 a 450 001 9910957321103321 005 20251017110103.0 010 $a9786610185634 010 $a9780309172288 010 $a0309172284 010 $a9781280185632 010 $a1280185635 010 $a9780309593885 010 $a0309593883 010 $a9780585259901 010 $a0585259909 035 $a(CKB)110986584752908 035 $a(OCoLC)45731829 035 $a(CaPaEBR)ebrary10055159 035 $a(SSID)ssj0000196421 035 $a(PQKBManifestationID)12024615 035 $a(PQKBTitleCode)TC0000196421 035 $a(PQKBWorkID)10143756 035 $a(PQKB)10300347 035 $a(MiAaPQ)EBC3376165 035 $a(Au-PeEL)EBL3376165 035 $a(CaPaEBR)ebr10055159 035 $a(OCoLC)923261685 035 $a(Perlego)4736736 035 $a(DNLM)929577 035 $a(BIP)6397735 035 $a(EXLCZ)99110986584752908 100 $a19991227d2000 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aManaged care systems and emerging infections $echallenges and opportunities for strengthening surveillance, research, and prevention : workshop summary, based on a workshop of the Forum on Emerging Infections, Division of Health Sciences Policy, Institute of Medicine /$fJonathan R. Davis, editor 205 $a1st ed. 210 $aWashington, DC $cNational Academy Press$d2000 215 $a1 online resource (127 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a9780309068284 311 08$a0309068282 320 $aIncludes bibliographical references. 327 $aManaged Care Systems and Emerging Infections -- Copyright -- REVIEWERS -- Preface -- Contents -- Summary -- BASIC AND CLINICAL RESEARCH -- CLINICAL PRACTICE GUIDELINES -- SURVEILLANCE AND MONITORING -- EDUCATION AND OUTREACH -- DRUG FORMULARIES -- 1 Introduction -- BACKGROUND -- ABOUT THE WORKSHOP AND ORGANIZATION OF THE WORKSHOP SUMMARY -- 2 Conducting Basic and Clinical Research in the Managed Care Setting -- PERSPECTIVE OF ASSOCIATION OF AMERICAN MEDICAL COLLEGES ON BASIC AND CLINICAL RESEARCH -- OPPORTUNITIES FOR POPULATION-BASED CLINICAL RESEARCH USING DATA FROM MANAGED CARE ORGANIZATIONS -- CONDUCTING CLINICAL RESEARCH WITHIN MANAGED CARE ORGANIZATIONS -- NIH ACTIVITIES RELATED TO CLINICAL RESEARCH AND MANAGED CARE -- SUMMARY OF CHALLENGES AND OPPORTUNITIES -- Supporting the Functions of Academic Health Centers -- Ensuring Adequate Databases for Clinical Research -- Exploiting the Unique Advantages of Managed Care for Surveillance and Research -- Promoting Collaboration -- Summary -- 3 Clinical Practice Guidelines -- CLINICAL PRACTICE GUIDELINES FOR EMERGING INFECTIONS AND MANAGED CARE -- REALITIES OF IMPLEMENTING GUIDELINES -- MAKING GUIDELINES INSTRUMENTAL: THEORY VERSUS PRACTICE -- SUMMARY OF CHALLENGES AND OPPORTUNITIES -- Promoting Adoption and Use of Guidelines in Managed Care Organizations -- Involving Clinicians in Guideline Development and Implementation -- The Need for Systemwide, Standardized Guidelines -- Promoting Professional and Public Education -- Summary -- 4 Surveillance and Monitoring -- AN EMPLOYER'S PERSPECTIVE -- MANAGED CARE AND INFECTIOUS DISEASE SURVEILLANCE: OPPORTUNITIES FOR COLLABORATION -- COLLABORATIVE SURVEILLANCE EFFORTS AND MONITORING OF DATA -- LATTER DAY SAINTS HOSPITAL'S SYSTEM -- LABORATORY-BASED REPORTING AND MANAGING ENCOUNTER-LEVEL DATA -- LABORATORY-BASED REPORTING ISSUES -- LEGAL CONCERNS. 327 $aSUMMARY OF CHALLENGES AND OPPORTUNITIES -- Understanding Professional Roles in Surveillance and Monitoring -- Ensuring Availability of Data -- Promoting Sharing of Data -- Tracking Nosocomial Infections -- Accurate Reporting of Encounter-Level Data -- Overcoming Structural Barriers -- Summary -- 5 Education and Outreach -- COORDINATING HEALTH PLAN RESEARCH AND EDUCATIONAL EFFORTS -- IMPACTS OF MANAGED CARE SYSTEM'S EDUCATIONAL EFFORTS ON CONTROL OF ANTIBIOTIC USE -- EDUCATION AND OUTREACH PERSPECTIVES OF THE NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES -- MANAGED CARE SYSTEMS AND EMERGING INFECTIONS: EDUCATION AND OUTREACH -- SUMMARY OF CHALLENGES AND OPPORTUNITIES -- Promote Professional Education Efforts -- Encourage Judicious Antibiotic Use -- Invest in Educational Programs -- Summary -- 6 Drug Formularies -- REGULATORY ISSUES -- RELATIONSHIP BETWEEN MANAGED CARE FORMULARIES AND TREATMENT OUTCOMES -- BACTERIAL RESISTANCE, THE ANTIBIOTIC FORMULARY, AND OTHER MANAGEMENT STRATEGIES -- ECONOMICS OF RESTRICTIONS ON PHARMACEUTICALS -- SUMMARY OF CHALLENGES AND OPPORTUNITIES -- Ensuring Availability of Current Information on New Drugs -- Managing Antibiotic Selective Pressure -- Need for New Management Strategies for Cost Reduction -- Achieving Quality Care and Cost Containment -- Summary -- 7 Concluding Remarks -- References -- Appendix A Veterans Health Administration and Infectious Disease -- CLINICAL RESEARCH -- CLINICAL PRACTICE -- Information Technology -- Homelessness -- SURVEILLANCE AND MONITORING -- Emerging Pathogens Initiative -- Annual Infectious Diseases and Infection Control Report -- EDUCATION -- DRUG FORMULARY -- Appendix B Glossary and Acronyms -- Acronyms -- Glossary -- Appendix C Workshop Agenda -- Appendix D Forum Member and Staff Biographies -- FORUM MEMBERS -- STUDY STAFF. 330 $aManaged Care Systems and Emerging Infections: Challenges and Opportunities for Strengthening Surveillance, Research, and Prevention Jonathan R. Davis, Editor; Based on a Workshop of the Forum on Emerging Infections, Institute of Medicine This workshop summary report from the IOM Forum on Emerging Infections, Managed Care Systems and Emerging Infections: Challenges and Opportunities for Strenghening Surveillance, Research and Prevention This book examines how the managed care revolution has created both problems and opportunities in the fight against infectious diseases. It highlights ways in which managed care systems can aid research, develop clinical guidelines, manage the use of antibiotics, support public education efforts, and monitor the spread of emerging infections and microbial resistance. 606 $aEmerging infectious diseases 606 $aManaged care plans (Medical care) 615 0$aEmerging infectious diseases. 615 0$aManaged care plans (Medical care) 676 $a362.1/04258 701 $aDavis$b Jonathan R$01805450 712 02$aInstitute of Medicine (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910957321103321 996 $aManaged care systems and emerging infections$94360764 997 $aUNINA