LEADER 05324nam 2200685Ia 450 001 9911019382303321 005 20200520144314.0 010 $a9786610921683 010 $a9781280921681 010 $a1280921684 010 $a9783527610945 010 $a3527610944 010 $a9783527610952 010 $a3527610952 035 $a(CKB)1000000000376507 035 $a(EBL)481955 035 $a(OCoLC)173136985 035 $a(SSID)ssj0000146429 035 $a(PQKBManifestationID)11137435 035 $a(PQKBTitleCode)TC0000146429 035 $a(PQKBWorkID)10183086 035 $a(PQKB)10041352 035 $a(MiAaPQ)EBC481955 035 $a(Perlego)2758931 035 $a(EXLCZ)991000000000376507 100 $a20061204d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEnantioselective organocatalysis $ereactions and experimental procedures /$fedited by Peter I. Dalko 210 $aWeinheim $cWiley-VCH ;$aChichester $cJohn Wiley [distributor]$d2007 215 $a1 online resource (563 p.) 300 $aDescription based upon print version of record. 311 08$a9783527315222 311 08$a3527315225 320 $aIncludes bibliographical references and index. 327 $aEnantioselective Organocatalysis; Contents; Preface; List of Contributors; List of Abbreviations; 1 Asymmetric Organocatalysis: A New Stream in Organic Synthesis; 1.1 Introduction; 1.2 Historical Background; 1.3 Catalysts; 1.3.1 Privileged Catalysts; 1.3.1.1 Proline [7k, 56]; 1.3.1.2 Cinchona Alkaloids [61]; 1.3.1.3 TADDOLs and Derivatives [63]; 1.3.1.4 Binaphthol Derivatives; 1.4 Reaction Types; 1.4.1 Covalent Catalysis; 1.4.2 Non-Covalent Organocatalysis; 1.5 How This Book is Organized; References and Notes; 2 Enamine Catalysis; 2.1 Aldol and Mannich-Type Reactions; 2.1.1 Introduction 327 $a2.1.2 Aldol Reactions2.1.2.1 Aldol Reactions of Alkyl Ketone Donors; 2.1.2.2 Aldol Reactions of ?-Oxyketone Donors; 2.1.2.3 Aldol Reactions of Aldehyde Donors; 2.1.2.4 Aldol Reactions with Ketone Acceptors; 2.1.2.5 Intramolecular Aldol Reactions; 2.1.2.6 Mechanism and Transition States of Aldol Reactions and Effects of Water on Aldol Reactions; 2.1.2.7 Catalyst Recycling; 2.1.2.8 Catalyst Development Strategies; 2.1.3 Mannich Reactions; 2.1.3.1 Mannich-Type Reactions of Aldehyde Donors with Glyoxylate Imines; 2.1.3.2 Mannich-Type Reactions of Aldehyde Donors with Other Preformed Imines 327 $a2.1.3.3 Three-Component Mannich Reactions using Aldehyde Donors2.1.3.4 Mannich-Type Reactions of Ketone Donors; References; 2.2 ?-Heteroatom Functionalization; 2.2.1 Introduction; 2.2.2 Direct ?-Amination of Aldehydes and Ketones; 2.2.3 Direct ?-Amination of ?-Cyanoacetates and ?-Dicarbonyl Compounds; 2.2.4 Direct ?-Oxygenation Reactions of Aldehydes and Ketones; 2.2.5 Direct ?-Oxygenation Reactions of ?-Ketoesters; 2.2.6 Direct ?-Halogenation Reactions of Aldehydes and Ketones; 2.2.6.1 Direct ?-Fluorination of Aldehydes; 2.2.6.2 Direct ?-Fluorination of ?-Ketoesters 327 $a2.2.6.3 Direct ?-Chlorination of Aldehydes and Ketones2.2.6.4 Direct ?-Chlorination of ?-Ketoesters; 2.2.6.5 Direct ?-Bromination of Aldehydes and Ketones; 2.2.7 Direct ?-Sulfenylation of Aldehydes; 2.2.8 Direct ?-Sulfenylation of Lactones, Lactams, and ?-Diketones; 2.2.9 Direct ?-Selenation of Aldehydes and Ketones; References; 2.3 Direct Conjugate Additions via Enamine Activation; 2.3.1 Introduction; 2.3.2 Factors Determining the Stereoselectivity of the Organocatalytic Conjugate Additions; 2.3.3 Addition of Ketones to Nitroolefins and Alkylidene Malonates; 2.3.3.1 Proline 327 $a2.3.3.2 Pyrrolidine Amines and Pyrrolidine Amine Salts as Catalysts for Michael-Type Addition of Ketones to Activated Olefins2.3.3.3 Chiral Primary Amines; 2.3.3.4 Amine/Thiourea Catalysts; 2.3.4 Addition of Aldehydes to Nitroolefins and Alkylidene Malonates; 2.3.4.1 Aminopyrrolidine Catalysts; 2.3.4.2 Addition of Aldehydes and Ketones to Enones; 2.4 Conclusions; References; 3 Iminium Catalysis; 3.1 Introduction; 3.2 The Catalysis Concept of Iminium Activation; 3.3 Development of the ''First-Generation'' Imidazolidinone Catalysts 327 $a3.4 Development of the ''Second-Generation'' Imidazolidinone Catalysts 330 $aIn this reference leaders at the forefront of research provide an insight into one of the hottest topics in organic synthesis, focusing on the most important enantioselective reactions.Clearly structured, each entry begins with a concise introduction, including a mechanistic discussion of the reaction, followed by preparative guidelines for newcomers, such as carefully selected working procedures with critical notes for bench chemists, rules of thumb and tips and tricks. 606 $aEnantioselective catalysis 606 $aOrganic compounds$xSynthesis 615 0$aEnantioselective catalysis. 615 0$aOrganic compounds$xSynthesis. 676 $a541.395 676 $a547.1395 676 $a547.2 701 $aDalko$b Peter I$01622280 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019382303321 996 $aEnantioselective organocatalysis$94422611 997 $aUNINA