LEADER 09202nam 2200721 a 450 001 9911019377003321 005 20200520144314.0 010 $a9786612689413 010 $a9781282689411 010 $a128268941X 010 $a9780470689592 010 $a0470689595 010 $a9780470689608 010 $a0470689609 035 $a(CKB)2550000000012038 035 $a(EBL)516973 035 $a(OCoLC)649476989 035 $a(SSID)ssj0000426125 035 $a(PQKBManifestationID)11310559 035 $a(PQKBTitleCode)TC0000426125 035 $a(PQKBWorkID)10372460 035 $a(PQKB)10304732 035 $a(MiAaPQ)EBC516973 035 $a(PPN)273307479 035 $a(Perlego)2773339 035 $a(EXLCZ)992550000000012038 100 $a20100202d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProcess analytical technology $espectroscopic tools and implementation strategies for the chemical and pharmaceutical industries /$fedited by Katherine A. Bakeev 205 $a2nd ed. 210 $aChichester, West Sussex $cWiley$d2010 215 $a1 online resource (583 p.) 300 $aDescription based upon print version of record. 311 08$a9780470722077 311 08$a047072207X 320 $aIncludes bibliographical references and index. 327 $aMachine generated contents note: Chapter 1 -- Overview of Process Analysis and PAT -- Jason E. Dickens -- 1.1 Introduction -- 1.2 Execution of Process Analysis Projects -- 1.3 Process Instrumentation -- 1.4 Conclusions -- 1.5 Glossy of Acronyms and Terms -- 1.6 References -- Chapter 2 -- Implementation of Process Analytical Technologies -- Robert Guenard and Gert Thurau -- 2.1 Introduction to implementation of process analytical technologies (PAT) in the industrial setting -- 2.2 Generalized process analytics work process -- 2.3 Considerations for PAT implementation in the pharmaceutical industry -- 2.4 Conclusions -- 2.5 References -- Chapter 3 -- Process Sampling: Theory of Sampling - the missing link in Process Analytical Technologies (PAT) -- Kim H. Esbensen and Peter Paasch-Mortensen -- 3.1 Introduction -- 3.2 Theory of Sampling TOS - introduction -- 3.3 Mass reduction as a specific sampling procedure -- 3.4 Fundamental Sampling Principle (FSP) -- 3.5 Sampling - a very practical issue -- 3.6 Reactors vessels - identical process sampling issues -- 3.7 Heterogeneity characterisaton of 1-d lots: variography -- 3.8 Data Quality - new insight from THE TOS -- 3.9 Validation in chemometrics AND PAT -- 3.10 Summary -- References -- Chapter 4 -- UV-visible spectroscopy for On-Line Analysis -- Marcel A. Liauw, Lewis C. Baylor and Patrick E. O'Rourke -- 4.1 Introduction -- 4.2 Theory -- 4.3 Instrumentation -- 4.4 Sample interface -- 4.5 Implementation -- 4.6 Applications -- 4.7 Detailed application notes -- 4.8 Conclusion -- References -- Chapter 5 -- Near-infrared Spectroscopy for Process Analytical Technology : Theory, Technology and Implementation -- Michael B. Simpson -- 5.1 Introduction -- 5.2 Theory of near-infrared spectroscopy -- 5.3 Analyser technologies in the near-infrared -- 5.4 The sampling interface -- 5.5 Practical examples of near-infrared analytical applications -- 5.6 Conclusion -- References -- 327 $aChapter 6 -- Infrared Spectroscopy for Process Analytical Applications -- John P. Coates -- 6.1 Introduction -- 6.2 Practical aspects of IR Spectroscopy -- 6.3 Instrumentation Design and Technology -- 6.4 Process IR Instrumentation -- 6.5 Applications of Process IR Analyzers -- 6.6 Process IR Analyzers: A Review -- 6.7 Trends and Directions -- Abbreviations and Acronyms -- References -- Chapter 7 -- Raman Spectroscopy -- Dr. Nancy L. Jestel -- 7.1 Attractive features of Raman spectroscopy -- 7.2 Potential issues with Raman spectroscopy -- 7.3 Fundamentals of Raman spectroscopy -- 7.4 Raman instrumentation -- 7.5 Quantitative Raman -- 7.6 Applications -- 7.7 Current state of process Raman spectroscopy -- 7.8 References -- Chapter 8 -- Near-Infrared Chemical Imaging for Product and Process Understanding -- E. Neil Lewis, Joseph W. Schoppelrei, Lisa Makein, Linda H. Kidder and Eunah Lee -- 8.1 The PAT initiative -- 8.2 The role of near-infrared chemical imaging (NIR-CI) in the pharmaceutical industry -- 8.3 Evolution of NIR imaging instrumentation -- 8.4 Chemical imaging principles -- 8.5 PAT applications -- 8.6 Processing case study one: estimating 'abundance' of sample components -- 8.7 Processing case study two: determining blend homogeneity through statistical analysis -- 8.8 Final thoughts -- Acknowledgements -- Chapter 9: -- Acoustic chemometric monitoring of industrial production processes -- Maths Halstensen & Kim H. Esbensen -- 9.1 What is acoustic chemometrics? -- 9.2 How acoustic chemometrics works -- 9.3 Industrial production process monitoring -- 9.4 Available on-line acoustic chemometric equipment -- 9.5 Discussion -- 9.6 Conclusions -- 9.7 References -- Chapter 10 -- Process NMR Spectroscopy: Technology and On-line Applications -- John C. Edwards, Ph.D. and Paul J. Giammatteo, Ph.D. -- 10.1 Introduction -- 10.2NMR Spectroscopy Overview -- 10.3 Process NMR Instrumentation -- 10.4 Postprocessing methodologies for NMR data -- 10.5 Advantages and limitations of NMR as a process analytical technology -- 10.6 On-line and at-line applications -- 10.7 Current Development and Applications -- 10.8 Conclusions -- References -- 327 $aChapter 11 -- Fluorescent Sensing and Process Analytical Applications -- Jason E. Dickens -- 11.1 Introduction -- 11.2 Luminescence fundamentals -- 11.3 LIF sensing fundamentals -- 11.4 LIF sensing instrumentation -- 11.5 Luminescent detection risks -- 11.6 Process analytical technology applications -- 11.7 Conclusions -- References -- Chapter 12 -- Chemometrics in Process Analytical Technology (PAT) -- Charles E. Miller -- 12.1 Introduction -- 12.2 Foundations of Chemometrics -- 12.3 Chemometric Methods in PAT -- 12.4 Overfitting and Model Validation -- 12.5 Outliers -- 12.6 Calibration Strategies in PAT -- 12.7 Sample and Variable Selection in Chemometrics -- 12.8 Troubleshooting/Improving an Existing Method -- 12.9 Calibration Transfer and Instrument Standardization -- 12.10 Chemometric Model Deployment Issues in PAT -- 12.11 People Issues -- 12.12 The Final Word -- Chapter 13 -- On-line PAT Applications of Spectroscopy in the Pharmaceutical Industry -- Brandye Smith-Goettler -- 13.1 Background -- 13.2 Reaction monitoring -- 13.3 Crystallization -- 13.4 API drying -- 13.5 Nanomilling -- 13.6 Hot-melt extrusion -- 13.7 Granulation -- 13.8 Powder blending -- 13.9 Compression -- 13.10 Coating -- 13.11 Biologics -- 13.12 Cleaning validation -- 13.13 Conclusions -- References -- Chapter 14 -- NIR spectroscopy in pharmaceutical analysis: Off-line and At-line PAT Applications -- Prof. Marcelo Blanco Romi;a -- 14.1 Introduction -- 14.2 Foundation of qualitative method development -- 14.3 Foundation of quantitative method development -- 14.4 Method validation -- 14.5 Calibration transfer -- 14.6 Pharmaceutical applications -- 14.7 Conclusions -- Chapter 15 -- Near-Infrared Spectroscopy (NIR) as a PAT tool in the Chemical Industry: Added value and implementation challenges -- Ann M. Brearley and Susan J. Foulk -- 15.1 Introduction -- 15.2 Successful process analyzer implementation -- 15.3 Example applications -- Chapter 16 -- Future trends for PAT for increased process understanding and growing applications in biomanufacturing -- Katherine A. Bakeev and Jose C. Menezes -- 16.1 Introduction -- 16.2 Regulatory Guidance and its Impact on PAT -- 16.3 Going Beyond Process Analyzers Towards Solutions -- 16.4 Emerging Application Areas of PAT -- 16.5 New and Emerging Sensor and Control Technologies -- 16.6 Advances in sampling: NeSSI[trademark symbol] -- 16.7 Challenges Ahead -- 16.8 Conclusion -- References. 330 $a"Process Analytical Technology 2nd ed. explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the spectroscopist. This second edition cover all the topics that are in the first edition, with additional chapters on process sampling, NMR spectroscopy and fluorescence spectroscopy (tbc). Other chapters cover the key spectroscopic tools, their applications in the chemical and pharmaceutical industries and basic chemometrics"--Provided by publisher. 606 $aChemistry, Technical 606 $aAnalytical chemistry$xTechnological innovations 606 $aAnalytical chemistry$xTechnique 606 $aSpectrum analysis 606 $aPharmaceutical chemistry 615 0$aChemistry, Technical. 615 0$aAnalytical chemistry$xTechnological innovations. 615 0$aAnalytical chemistry$xTechnique. 615 0$aSpectrum analysis. 615 0$aPharmaceutical chemistry. 676 $a660/.2 701 $aBakeev$b Katherine A$0942478 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019377003321 996 $aProcess analytical technology$92126814 997 $aUNINA