LEADER 05474nam 2200721Ia 450 001 9911019339303321 005 20200520144314.0 010 $a9786611939441 010 $a9781281939449 010 $a1281939447 010 $a9780470699836 010 $a0470699833 010 $a9780470699829 010 $a0470699825 035 $a(CKB)1000000000551348 035 $a(EBL)366773 035 $a(SSID)ssj0000111891 035 $a(PQKBManifestationID)11143326 035 $a(PQKBTitleCode)TC0000111891 035 $a(PQKBWorkID)10080567 035 $a(PQKB)10215772 035 $a(MiAaPQ)EBC366773 035 $a(CaSebORM)9780470027110 035 $a(OCoLC)501313843 035 $a(PPN)190415940 035 $a(OCoLC)832729102 035 $a(OCoLC)ocn832729102 035 $a(Perlego)2752885 035 $a(EXLCZ)991000000000551348 100 $a20080722d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBioinformatics for vaccinology /$fDarren R. Flower 205 $a1st edition 210 $aChichester, West Sussex, England ;$aHoboken, NJ $cJohn Wiley & Sons$d2008 215 $a1 online resource (314 p.) 300 $aDescription based upon print version of record. 311 08$a9780470027110 311 08$a0470027118 320 $aIncludes bibliographical references and index. 327 $aBioinformatics for Vaccinology; Contents; Preface; Acknowledgements; Exordium; 1 Vaccines: Their place in history; Smallpox in history; Variolation; Variolation in history; Variolation comes to Britain; Lady Mary Wortley Montagu; Variolation and the Sublime Porte; The royal experiment; The boston connection; Variolation takes hold; The Suttonian method; Variolation in Europe; The coming of vaccination; Edward Jenner; Cowpox; Vaccination vindicated; Louis Pasteur; Vaccination becomes a science; Meister, Pasteur and rabies; A vaccine for every disease; In the time of cholera 327 $aHaffkine and choleraBubonic plague; The changing face of disease; Almroth wright and typhoid; Tuberculosis, Koch, and Calmette; Vaccine BCG; Poliomyelitis; Salk and Sabin; Diphtheria; Whooping cough; Many diseases, many vaccines; Smallpox: Endgame; Further reading; 2 Vaccines: Need and opportunity; Eradication and reservoirs; The ongoing burden of disease; Lifespans; The evolving nature of disease; Economics, climate and disease; Three threats; Tuberculosis in the 21 st century; HIV and AIDS; Malaria: Then and now; Influenza; Bioterrorism; Vaccines as medicines 327 $aVaccines and the pharmaceutical industryMaking vaccines; The coming of the vaccine industry; 3 Vaccines: How they work; Challenging the immune system; The threat from bacteria: Robust, diverse, and endemic; Microbes, diversity and metagenomics; The intrinsic complexity of the bacterial threat; Microbes and humankind; The nature of vaccines; Types of vaccine; Carbohydrate vaccines; Epitopic vaccines; Vaccine delivery; Emerging immunovaccinology; The immune system; Innate immunity; Adaptive immunity; The microbiome and mucosal immunity; Cellular components of immunity; Cellular immunity 327 $aThe T cell repertoireEpitopes: The immunological quantum; The major histocompatibility complex; MHC nomenclature; Peptide binding by the MHC; The structure of the MHC; Antigen presentation; The proteasome; Transporter associated with antigen processing; Class II processing; Seek simplicity and then distrust it; Cross presentation; T cell receptor; T cell activation; Immunological synapse; Signal 1, signal 2, immunodominance; Humoral immunity; Further reading; 4 Vaccines: Data and databases; Making sense of data; Knowledge in a box; The science of -omes and -omics; The proteome 327 $aSystems biologyThe immunome; Databases and databanks; The relational database; The XML database; The protein universe; Much data, many databases; What proteins do; What proteins are; The amino acid world; The chiral nature of amino acids; Naming the amino acids; The amino acid alphabet; Defining amino acid properties; Size, charge and hydrogen bonding; Hydrophobicity, lipophilicity and partitioning; Understanding partitioning; Charges, ionization, and pka; Many kinds of property; Mapping the world of sequences; Biological sequence databases; Nucleic acid sequence databases 327 $aProtein sequence databases 330 $a"... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues-making the book enticing and useful, all at once..." Human Vaccines, 2010 ""... This book has sever 606 $aImmunoinformatics 606 $aVaccines$xDesign$xData processing 615 0$aImmunoinformatics. 615 0$aVaccines$xDesign$xData processing. 676 $a615/.3720285 700 $aFlower$b Darren R$0472707 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019339303321 996 $aBioinformatics for vaccinology$9226177 997 $aUNINA