LEADER 03281oam 2200493z- 450 001 9911019333603321 005 20230626035424.0 010 $a9783527823413 010 $a3527823417 010 $a9783527823420 010 $a3527823425 010 $a9783527823437 010 $a3527823433 035 $a(CKB)5580000000394956 035 $a(VLeBooks)9783527823420 035 $a(Perlego)3863299 035 $a(EXLCZ)995580000000394956 100 $a20230323d2022 uy | 101 0 $aeng 200 00$aHuman and Animal Filariases $eLandscape, Challenges, and Control 205 $a1st 210 $cWiley-VCH$d2022 210 $cWeinheim, Germany :$cWiley,$d[2023] 215 $a1 online resource 225 0 $aDrug Discovery in Infectious Diseases 311 08$a9783527346592 311 08$a3527346597 330 $a Human and Animal Filariases The rational approach to controlling human and animal diseases caused by nematodes Filariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs. Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination. Human and Animal Filariases readers will find: A comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery Practical information on assay development, target validation, and required drug product profiles Insights from global experts from leading academic institutions as well as from pharma and healthcare companies Human and Animal Filariases is a unique reference for parasitologists, veterinarians, as well as professionals in the pharmaceutical industry and in public health agencies. 606 $aFilarial worms 606 $aFilariasis 606 $aParasitic diseases 606 $aParasitology 615 0$aFilarial worms. 615 0$aFilariasis. 615 0$aParasitic diseases. 615 0$aParasitology. 676 $a595.7857 701 $aKaminsky$b Ronald$01840766 701 $aGeary$b Timothy G$01840767 701 $aSelzer$b Paul M$01062877 906 $aBOOK 912 $a9911019333603321 996 $aHuman and Animal Filariases$94420334 997 $aUNINA