LEADER 05372nam 22006854a 450 001 9911019314703321 005 20200520144314.0 010 $a9786611135317 010 $a9781281135315 010 $a1281135313 010 $a9780470517437 010 $a0470517433 010 $a9780470517444 010 $a0470517441 035 $a(CKB)1000000000413971 035 $a(EBL)326413 035 $a(OCoLC)476124182 035 $a(SSID)ssj0000176759 035 $a(PQKBManifestationID)11170150 035 $a(PQKBTitleCode)TC0000176759 035 $a(PQKBWorkID)10206033 035 $a(PQKB)10010364 035 $a(MiAaPQ)EBC326413 035 $a(PPN)188664904 035 $a(Perlego)2762253 035 $a(EXLCZ)991000000000413971 100 $a20070604d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIminosugars $efrom synthesis to therapeutic applications /$feditors, Philippe Compain and Olivier R. Martin 210 $aChichester, West Sussex, England ;$aHoboken, NJ, USA $cJ. Wiley$dc2007 215 $a1 online resource (487 p.) 300 $aDescription based upon print version of record. 311 08$a9780470033913 311 08$a0470033916 320 $aIncludes bibliographical references and index. 327 $aIminosugars; Contents; Foreword; Preface; List of contributors; 1 Iminosugars: past, present and future; 2 Naturally occurring iminosugars and related alkaloids: structure, activity and applications; 2.1 Introduction; 2.2 -Glucosidase inhibitors; 2.3 -Glucosidase inhibitors; 2.4 - and -Galactosidase inhibitors; 2.5 -Mannosidase inhibitors; 2.6 Concluding remarks and future prospects; References; 3 General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries; 3.1 Introduction; 3.2 Monocyclic compounds; 3.3 1-N-Iminosugars; 3.4 Bicyclic compounds 327 $a3.5 Other bicyclic compounds3.6 Iminosugar conjugates; 3.7 Conclusions; References; 4 Iminosugar C-glycosides: synthesis and biological activity; 4.1 Introduction; 4.2 Synthesis of iminosugar C-glycosides; 4.3 Biological activity of iminosugar C-glycosides; 4.4 Conclusion; References; 5 Imino-C-disaccharides and analogues: synthesis and biological activity; 5.1 Introduction; 5.2 Synthesis of imino-C-disaccharides; 5.3 Conformations of imino-C-disaccharides; 5.4 Glycosidase inhibitory activities of imino-C-disaccharides 327 $a5.5 Efficient combinatorial method for the discovery of glycosidase inhibitors5.6 Antitumour activity of new -mannosidase inhibitors; 5.7 Conclusion; References; 6 Isofagomine, noeuromycin and other 1-azasugars, iminosugar-related glycosidase inhibitors; 6.1 Introduction; 6.2 1-Azasugars that are piperidines (isofagomine, noeuromycin, etc.); 6.3 1-Azasugars that are hydrazines; 6.4 1-Azasugars that are oxazines; 6.5 1-Azasugars that are piperidones; 6.6 Sulphur-containing analogues of 1-azasugars; 6.7 Slow inhibition and thermodynamics of binding 327 $a6.8 Are 1-azasugars (and iminosugars) transition state analogues?References; 7 Iminosugar-based glycosyltransferase inhibitors; 7.1 Biological role and structural features of glycosyltransferases; 7.2 Development of inhibitors of glycosyltransferases; 7.3 Conclusion; References; 8 Transition state analogue inhibitors of N-ribosyltransferases; 8.1 Introduction; 8.2 Nucleoside hydrolases; 8.3 Purine nucleoside phosphorylases (PNPs); 8.4 5'-Methylthioadenosine (MTA) nucleosidases and phosphorylases; 8.5 Ricin A-chain; References; 9 Iminosugars as antiviral agents; 9.1 Introduction 327 $a9.2 The relationship between glucosidase inhibition and antiviral action9.3 Fate of viral glycoproteins in glucosidase-inhibited cells; 9.4 Specificity of glucosidase inhibition; 9.5 N-Alkyl DNJs inhibit virus growth by non-glucosidase inhibitory mechanisms - other potential activities of these compounds; 9.6 New directions for improving glucosidase inhibitors as antiviral agents; References; 10 Iminosugars as active-site-specific chaperones for the treatment of lysosomal storage disorders; 10.1 Introduction; 10.2 Degradation of glycosphingolipids 327 $a10.3 Lysosomal enzyme biosynthesis and ER-associated degradation (ERAD) 330 $aIminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970's, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is "a boom time" for iminosugar 606 $aImino sugars$xSynthesis 606 $aImino sugars$xTherapeutic use 615 0$aImino sugars$xSynthesis. 615 0$aImino sugars$xTherapeutic use. 676 $a612/.01578 701 $aCompain$b Philippe$01837796 701 $aMartin$b Olivier R$01837797 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019314703321 996 $aIminosugars$94416628 997 $aUNINA LEADER 04277nam 22006855 450 001 9910971930503321 005 20241107101903.0 010 $a9781400839803 010 $a1400839807 024 7 $a10.1515/9781400839803 035 $a(CKB)2670000000099552 035 $a(EBL)729951 035 $a(OCoLC)748241719 035 $a(SSID)ssj0000590361 035 $a(PQKBManifestationID)11352013 035 $a(PQKBTitleCode)TC0000590361 035 $a(PQKBWorkID)10671604 035 $a(PQKB)10044229 035 $a(DE-B1597)453765 035 $a(OCoLC)979835532 035 $a(DE-B1597)9781400839803 035 $a(MiAaPQ)EBC729951 035 $a(ODN)ODN0001546439 035 $a(Perlego)735180 035 $a(EXLCZ)992670000000099552 100 $a20190708d2011 fg 0 101 0 $aeng 135 $aurnn#---|u||u 181 $ctxt 182 $cc 183 $acr 200 10$aFault Lines $eHow Hidden Fractures Still Threaten the World Economy /$fRaghuram G. Rajan 205 $aWith a New afterword by the author 210 $d2011 210 1$aPrinceton, NJ :$cPrinceton University Press,$d[2011] 210 4$dİ2011 215 $a1 online resource (283 p.) 300 $aDescription based upon print version of record. 311 08$a0-691-15263-2 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tAcknowledgments --$tIntroduction --$tONE. Let Them Eat Credit --$tTWO. Exporting to Grow --$tTHREE. Flighty Foreign Financing --$tFOUR. A Weak Safety Net --$tFIVE. From Bubble to Bubble --$tSIX. When Money Is the Measure of All Worth --$tSEVEN. Betting the Bank --$tEIGHT. Reforming Finance --$tNINE. Improving Access to Opportunity in America --$tTEN. The Fable of the Bees Replayed --$tEpilogue --$tAfterword to the Paperback Edition --$tNotes --$tIndex 330 $aRaghuram Rajan was one of the few economists who warned of the global financial crisis before it hit. Now, as the world struggles to recover, it's tempting to blame what happened on just a few greedy bankers who took irrational risks and left the rest of us to foot the bill. In Fault Lines, Rajan argues that serious flaws in the economy are also to blame, and warns that a potentially more devastating crisis awaits us if they aren't fixed. Rajan shows how the individual choices that collectively brought about the economic meltdown--made by bankers, government officials, and ordinary homeowners--were rational responses to a flawed global financial order in which the incentives to take on risk are incredibly out of step with the dangers those risks pose. He traces the deepening fault lines in a world overly dependent on the indebted American consumer to power global economic growth and stave off global downturns. He exposes a system where America's growing inequality and thin social safety net create tremendous political pressure to encourage easy credit and keep job creation robust, no matter what the consequences to the economy's long-term health; and where the U.S. financial sector, with its skewed incentives, is the critical but unstable link between an overstimulated America and an under consuming world. In Fault Lines, Rajan demonstrates how unequal access to education and health care in the United States puts us all in deeper financial peril, even as the economic choices of countries like Germany, Japan, and China place an undue burden on America to get its policies right. He outlines the hard choices we need to make to ensure a more stable world economy and restore lasting prosperity. 606 $aIncome distribution$xHistory$y21st century$zUnited States 606 $aGlobal Financial Crisis, 2008-2009$y21st century 606 $aEconomic history 607 $aUnited States$xSocial conditions$y21st century 615 0$aIncome distribution$xHistory 615 0$aGlobal Financial Crisis, 2008-2009 615 0$aEconomic history. 676 $a330.9/0511 676 $a330.9051 676 $a330.90511 686 $aBUS069000$aPOL024000$2bisacsh 700 $aRajan$b Raghuram$01331365 801 0$bDE-B1597 801 1$bDE-B1597 906 $aBOOK 912 $a9910971930503321 996 $aFault Lines$94472815 997 $aUNINA