LEADER 03843nam 2200709 a 450 001 9911019305503321 005 20200520144314.0 010 $a9786612347962 010 $a9781282347960 010 $a1282347969 010 $a9780470514900 010 $a0470514906 010 $a9780470514917 010 $a0470514914 035 $a(CKB)1000000000377215 035 $a(EBL)470445 035 $a(OCoLC)609849343 035 $a(SSID)ssj0000305463 035 $a(PQKBManifestationID)11925006 035 $a(PQKBTitleCode)TC0000305463 035 $a(PQKBWorkID)10294237 035 $a(PQKB)11001333 035 $a(MiAaPQ)EBC470445 035 $a(Perlego)2772552 035 $a(EXLCZ)991000000000377215 100 $a20090715d1996 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aP2 purionoceptors $elocalization, function and transduction mechanisms 210 $aChichester $cWiley$d1996 215 $a1 online resource (350 p.) 225 1 $aCiba Foundation symposium ;$v198 300 $aEditors: Derek J. Chadwick (organizer) and Jamie A. Goode. 300 $aSymposium held at Ciba Foundation, London, 11-13 July 1995. 311 08$a9780471961253 311 08$a0471961256 327 $aP2 PURINOCEPTORS: LOCALIZATION, FUNCTION AND TRANSDUCTION MECHANISMS; Contents; Participants; P2 purinoceptors: historical perspective and cIassification; The diadenosine polyphosphate receptors: P2D purinoceptors; P2T purinoceptors: ADP receptors on platelets; P2Z purinoceptors; P2X receptors: a third major class of Iigand-gated ion channels; P2 purinoceptors and pyrimidinoceptors of catecholamine-producing cells and immunocytes; Trophic actions of extracellular ATP on astrocytes, synergistic interactions with fibroblast growth factors and underlying signal tranduction mechanisms 327 $aTrophic roles of P2 purinoceptors in central nervous system astroglial cellsTransduction mechanisms of P2Z purinoceptors; The diverse series of recombinant P2Y purinoceptors; General discussion I; P2U purinoceptors: cDNA cloning, signal transduction mechanisms and structure-function analysis; Functional properties of native and cloned P2X receptors; ATP as a co-transmitter with no rad ren al i ne i n sym pat he t i c nerves-function and fate; ATP release and its prejunctional modulation; General discussion II 327 $aInvolvement of distinct receptors in the actions of extracellular uridine nucleotidesFeatures of P2X receptor-mediated synapses in the rat brain: why doesn't ATP kill the postsynaptic cell?; P2 purinoceptors in the immune system; General discussion Ill; Challenges in developing P2 purinoceptor-based therapeutics; Summing-up; Index of contributors; Subject index 330 $aMany different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas. 410 0$aCiba Foundation symposium ;$v198. 606 $aPurines$xReceptors$vCongresses 606 $aAdenosine triphosphate$xReceptors$vCongresses 606 $aNeurotransmitter receptors$vCongresses 615 0$aPurines$xReceptors 615 0$aAdenosine triphosphate$xReceptors 615 0$aNeurotransmitter receptors 676 $a599 676 $a599.0188 676 $a612.0157 701 $aChadwick$b Derek$091632 701 $aGoode$b James$01841825 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019305503321 996 $aP2 purionoceptors$94421689 997 $aUNINA