LEADER 03766nam 2200685 a 450 001 9911019303103321 005 20200520144314.0 010 $a9786612346002 010 $a9781282346000 010 $a1282346008 010 $a9780470513484 010 $a0470513489 010 $a9780470513491 010 $a0470513497 035 $a(CKB)1000000000377311 035 $a(EBL)470679 035 $a(SSID)ssj0000289519 035 $a(PQKBManifestationID)11911073 035 $a(PQKBTitleCode)TC0000289519 035 $a(PQKBWorkID)10402998 035 $a(PQKB)10120410 035 $a(MiAaPQ)EBC470679 035 $a(OCoLC)181169117 035 $a(Perlego)2751903 035 $a(EXLCZ)991000000000377311 100 $a19870402d1987 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAutoimmunity and autoimmune disease 210 $aChichester ;$aNew York $cWiley$d1987 215 $a1 online resource (290 p.) 225 1 $aCiba Foundation symposium ;$v129 300 $aEditors: David Evered (organizer) and Julie Whelan. 300 $a"Symposium on Autoimmunity and Autoimmune Disease, held at the Ciba Foundation, London, 30 September-2 October 1986"--Contents p. 300 $a"A Wiley-Interscience publication." 311 08$a9780471910954 311 08$a0471910953 320 $aIncludes bibliographical references and indexes. 327 $aAUTOIMMUNITY AND AUTOIMMUNE DISEASE; Contents; Participants; Introduction; Cardiac myosin and autoimmune myocarditis; Intracellular autoantigens: diagnostic fingerprints but aetiological dilemmas; Significance of carbohydrate components of cell surfaces; How is tolerance generated?; Therapeutic immune regulation in experimental interstitial nephritis with suppressor T cells and their soluble factors; Regulation of HL4 class II expression and its role in autoimmune disease; Id iotypes and autoimmunity 327 $aMolecular basis for the cross-reactive idiotypes on human anti-lgG autoanti bodies (rheumatoid factors)Autoimmunity and immunodeficiency disease; Deficiency of the effector mechanisms of the immune response and au toimmu n ity; General discussion; Monoclonal anti-la antibody therapy in animal models of autoimmune disease; Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes; Manipulation of idiotype networks in autoimmunity; Interferons: cytokines in autoimmunity; Specific immunoabsorption; Final general discussion; Chairman's summing-up; Index of contributors 327 $aSubject Index 330 $aThis work focuses on the autoimmune processes that have now been proven to underlie a number of serious diseases, including diabetes mellitus, rheumatoid arthritis and multiple sclerosis. Papers explore the rapidly expanding developments in research on immune response and regulation, and their potential in the development of treatments for autoimmune diseases. The wide range of subjects covered here include: the nature of intracellular and cell surface-derived ``self'' antigens; competing theories of the generation of immune tolerance and their implications of current theories for research and 410 0$aCiba Foundation symposium ;$v129. 606 $aAutoimmune diseases$vCongresses 615 0$aAutoimmune diseases 676 $a616.9 676 $a616.978 701 $aEvered$b David$0857127 701 $aWhelan$b Julie$0322651 712 12$aSymposium on Autoimmunity and Autoimmune Disease$f(1986 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019303103321 996 $aAutoimmunity and autoimmune disease$94421679 997 $aUNINA