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100   $a19991028d2000      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aMechanisms and biological significance of pulsatile hormone release
210   $aChichester, West Sussex, England ;$aNew York $cWiley$d2000
215   $a1 online resource (281 p.)
225 1 $aNovartis Foundation symposium ;$v227
300   $a"Symposium on Mechanisms and Biological Significance of Pulsatile Hormone Secretion, held at the Novartis Foundation, London, 2-4 March 1999"--P. v.
311 08$a9780471999188 
311 08$a0471999180 
320   $aIncludes bibliographical references and indexes.
327   $aMECHANISMS AND BIOLOGICAL SIGNIFICANCE OF PULSATILE HORMONE SECRETION; Contents; Participants; Introduction; Rhythmic transcription: the molecular basis of oscillatory melatonin synthesis; Discussion; The frequency encoding of pulsatility; Discussion; Timing-dependent modulation of insulin mitogenic versus metabolic signalling; Discussion; Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression; Discussion; Orderliness of hormone release; Discussion
327   $aPrediction and significance of the temporal pattern of hormone secretion in disease states Discussion; Therapeutic implications of circadian rhythms in cancer patients; Discussion; Pathophysiology of human circadian rhythms; Discussion; Nature of altered pulsatile hormone release and neuroendocrine network signalling in human ageing: clinical studies of the somatotropic, gonadotropic, corticotropic and insulin axes; Discussion; Pulsatile insulin secretion; Discussion; Control of growth hormone (GH) release by GH secretagogues; Discussion
327   $aPulsatile parathyroid hormone secretion in health and diseaseDiscussion; Significance of pulsatility in the HPA axis; Discussion; Closing remarks; Index of contributors; Subject index
330   $aThis exciting book brings together an international and interdisciplinary group of experts to discuss the importance of pulsatile signalling in the induction of biological responses. Coverage includes the basic mechanisms involved in hormone pulsatility, the significance of pulsatility in normal and disease conditions, the relevance of circadian rhythms, changes with ageing, and detailed consideration of specific peptide hormone systems. This book includes contributions from professionals working in both basic and clinical research and reveals much new and exciting work in this area and promis
410  0$aNovartis Foundation symposium ;$v227.
606   $aHormones$xSecretion$vCongresses
606   $aBiological rhythms$xMolecular aspects$vCongresses
615  0$aHormones$xSecretion
615  0$aBiological rhythms$xMolecular aspects
676   $a572
676   $a612.4/05
676   $a612.405
712 12$aSymposium on Mechanisms and Biological Significance of Pulsatile Hormone Secretion$f(1999 :$eLondon, England)
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9911019236703321
996   $aMechanisms and biological significance of pulsatile hormone release$94418715
997   $aUNINA