LEADER 04102nam 2200589 450 001 9910155388703321 005 20200520144314.0 010 $a3-11-045939-6 024 7 $a10.1515/9783110459395 035 $a(CKB)3850000000000968 035 $a(MiAaPQ)EBC4768891 035 $a(DE-B1597)460711 035 $a(OCoLC)985981419 035 $a(OCoLC)992455431 035 $a(DE-B1597)9783110459395 035 $a(PPN)202112233 035 $a(Au-PeEL)EBL4768891 035 $a(CaPaEBR)ebr11316713 035 $a(CaONFJC)MIL967010 035 $a(OCoLC)962064202 035 $a(EXLCZ)993850000000000968 100 $a20161222h20162016 uy 0 101 0 $ager 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aBenjamin Constant $ecorrespondance generale, XI (1819-1820) /$fTextes etablis et annotes par Cecil Courtney et Paul Rowe ; avee la collaboration de Adrianne Tooke et Dennis Wood 210 1$aBerlin, [Germany] ;$aBoston, [England] :$cDe Gruyter,$d2016. 210 4$d©2016 215 $a1 online resource (776 pages) $cillustrations 225 0 $aBenjamin Constant : Ceuvres Completes : Serie Correspondance Generale ;$v11 311 $a3-11-042712-5 320 $aIncludes bibliographical references and index. 327 $tFrontmatter -- $tTable des matières -- $tListe des illustrations -- $tIntroduction au onzième volume -- $tAbréviations et sigles bibliographiques -- $tChronologie -- $tCorrespondance, (1819-1820). Part I -- $tCorrespondance, (1819-1820). Part II -- $tCorrespondance, (1819-1820). Part III -- $tAppendices -- $tRépertoire -- $tTables et Index 330 $aCet onzième volume de la Correspondance générale comprend 473 lettres écrites au cours des années 1819 et 1820, époque où Constant, comme député de la Sarthe à partir de mars 1819, ajoute à sa réputation de journaliste et de publiciste celle de brillant orateur et de défenseur des principes des libéraux. Le présent volume constitue aussi un précieux document sur la vie intellectuelle et politique de l'époque, non seulement à Paris, mais aussi dans la Sarthe, grâce à l'abondante correspondance de Constant avec de nombreux habitants de ce département. Le lecteur y trouvera aussi des lettres intéressantes entre Constant et certains membres de sa famille, notamment celles de sa demi-s?ur Louise, qui en décembre 1820 publie son premier roman Alphonse et Mathilde. 330 $aThis eleventh volume of the Correspondance générale, which covers the years 1819 and 1820, is a valuable document of the intellectual life of the period as well as the multiple activities of Benjamin Constant as député of the Sarthe, orator, journalist, publicist and champion of political and civil liberties during the second Restoration. Cet onzième volume de la Correspondance générale comprend 473 lettres écrites au cours des années 1819 et 1820, époque où Constant, comme député de la Sarthe à partir de mars 1819, ajoute à sa réputation de journaliste et de publiciste celle de brillant orateur et de défenseur des principes des libéraux. Le présent volume constitue aussi un précieux document sur la vie intellectuelle et politique de l'époque, non seulement à Paris, mais aussi dans la Sarthe, grâce à l'abondante correspondance de Constant avec de nombreux habitants de ce département. Le lecteur y trouvera aussi des lettres intéressantes entre Constant et certains membres de sa famille, notamment celles de sa demi-s?ur Louise, qui en décembre 1820 publie son premier roman Alphonse et Mathilde. 606 $aNovelists, Swiss$y19th century$vCorrespondence 608 $aElectronic books. 615 0$aNovelists, Swiss 676 $a848.609 700 $aCourtney$b Cecil$0255612 702 $aRowe$b Paul 702 $aTooke$b Adrianne 702 $aWood$b Dennis 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910155388703321 996 $aBenjamin Constant$92477460 997 $aUNINA LEADER 05382nam 22006974a 450 001 9911019165603321 005 20200520144314.0 010 $a9786610520381 010 $a9781280520389 010 $a1280520388 010 $a9783527605293 010 $a3527605290 010 $a9783527601455 010 $a3527601457 035 $a(CKB)1000000000019317 035 $a(EBL)481642 035 $a(OCoLC)174056223 035 $a(SSID)ssj0000104500 035 $a(PQKBManifestationID)11138246 035 $a(PQKBTitleCode)TC0000104500 035 $a(PQKBWorkID)10079755 035 $a(PQKB)11381024 035 $a(MiAaPQ)EBC481642 035 $a(Perlego)2752104 035 $a(EXLCZ)991000000000019317 100 $a20030331d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aApoptosis and autoimmunity /$fedited by M. Hermann and J.R. Kalden 210 $aWeinheim $cWiley-VCH$dc2003 215 $a1 online resource (405 p.) 300 $a"From mechanism to treatments"--Cover. 311 08$a9783527304424 311 08$a3527304428 320 $aIncludes bibliographical references and index. 327 $aApoptosis and Autoimmunity; Preface; Contents; List of Contributors; Part 1 General Features of Apoptosis; 1 Apoptosis and Autoimmunity; 1.1 Introduction; 1.2 Autoimmune Diseases Associated with Targeted Cell Destruction; 1.2.1 What is the Mode of Cell Death?; 1.2.2 What Cells and What Effector Pathways are Responsible for Cell Death?; 1.3 Autoimmune Diseases Associated with Enhanced Cell Growth and Survival; 1.4 Autoimmune Diseases Associated with Abnormal Processing of Dying Cells; 1.5 Conclusions; 1.6 References; 2 Caspase Knockouts: Matters of Life and Death 327 $a2.1 Death, Development and Immune Function2.2 Apoptotic Pathways: from Nematode to Mammals; 2.3 Triggering a Killer: General Aspects of Caspase Activation; 2.4 Caspase-1 and -11: More than Mediators of Inflammatory Cytokines?; 2.5 Caspase-8 and the FAS Signaling Pathway; 2.6 Caspase-3: The Chief Executioner?; 2.7 Caspase-9: Mitochondrial Activation and the Apoptosome; 2.8 Caspase-2: A Duality of Function; 2.9 Caspase-12: Responding to Stress; 2.10 Compensatory Caspase Activation: A Caveat to Knockout Analysis; 2.11 Caspases: More than Simple Killers; 2.12 Concluding Remarks; 2.13 References 327 $aPart 2 Clearance of Apoptotic Cells3 Anti-inflammatory and Immunoregulatory Effects of Apoptotic Cells; 3.1 Introduction; 3.2 Anti-inflammatory Effects of Apoptotic Cells on Monocytes/Macrophages; 3.3 The Role of Anti-inflammatory Cytokines for the Inhibition of Pro-inflammatory Cytokine Production; 3.4 Monocyte/Macrophage Receptors receiving the Anti-inflammatory Signal from Apoptotic Cells; 3.5 Intracellular Signaling Events Causing the Anti-inflammatory State in Macrophages; 3.6 Apoptotic Cells Impair MHC Class II Surface Expression on Monocytes 327 $a3.7 Influence of Apoptotic Cells on DC Function in Allogeneic MLR3.8 The Presence of Apoptotic Cells can Shift the T(h) Cell Response towards T(h)2; 3.9 Apoptotic Cells Suppress Delayed-type Hypersensitivity (DTH) In Vivo; 3.10 Necrosis and Inflammation; 3.11 Implications of the Anti-inflammatory and Immunodulatory Effects of Apoptotic Cells for Health and Disease; 3.11.1 Apoptosis and Pregnancy; 3.11.2 Apoptosis and Irradiation; 3.11.3 Apoptosis and Cancer; 3.11.4 Apoptosis and Infections; 3.11.5 Apoptosis and Blood Transfusions; 3.12 References; 4 Complement and Apoptosis; 4.1 Introduction 327 $a4.2 Programmed Cell Death (PCD)4.3 Complement; 4.4 Complement and Apoptosis; 4.4.1 Role of Complement in the Execution Phase; 4.4.2 Complement Activation by Apoptotic Cells; 4.5 Apoptosis, Complement and Autoimmunity; 4.6 References; 5 Soluble Factors that Bind to Dying Cells Control the Outcome of Corpse Disposal: The Role of Pentraxins, Collectins and Autoantibodies; 5.1 Introduction; 5.2 Soluble Factors Involved in Apoptotic Cell Recognition and Internalization; 5.2.1 Corpse Clearance at Rest: Collectins; 5.2.2 Corpse Clearance at Rest: Cationic Factors and Other PS-binding Moieties 327 $a5.2.3 Corpse Clearance during Acute Inflammation: Pentraxins 330 $aThis is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies. 606 $aApoptosis 606 $aAutoimmunity 606 $aAutoimmune diseases 615 0$aApoptosis. 615 0$aAutoimmunity. 615 0$aAutoimmune diseases. 676 $a571.9/73 701 $aHerrmann$b M$g(Martin),$cDr.$01837364 701 $aKalden$b J. R$g(Joachim Robert)$01837365 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019165603321 996 $aApoptosis and autoimmunity$94416073 997 $aUNINA