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100   $a20061031d2007      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aDecoding the genomic control of immune reactions
210   $aChichester ;$aHoboken, NJ $cWiley$d2007
215   $a1 online resource (230 p.)
225 1 $aNovartis Foundation symposium ;$v281
300   $aDescription based upon print version of record.
311 08$a9780470027554 
311 08$a047002755X 
320   $aIncludes bibliographical references and indexes.
327   $aDecoding the Genomic Control of Immune Reactions; Contents; Chair's introduction; Transcriptional regulatory networks in macrophages; DISCUSSION; The RIKEN mouse transcriptome: lessons learned and implications for the regulation of immune reactions; DISCUSSION; Molecular pathways for lymphangiogenesis and their role in human disease; DISCUSSION; GENERAL DISCUSSION I; Specifying the patterns of immune cell migration; DISCUSSION; Human monogenic disorders that confer predisposition to specific infections; DISCUSSION; The genetic control of susceptibility to Mycobacterium tuberculosis
327   $aDISCUSSIONTh2 lymphoproliferative disorders resulting from defective LAT signalosomes; DISCUSSION; Genetic analysis of systemic autoimmunity; DISCUSSION; Genetic resistance to smallpox: lessons from mousepox; DISCUSSION; The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes; DISCUSSION; Genetic control of host-pathogen interactions in mice; DISCUSSION; Mycobacterium tuberculosis and its ability to resist immunity; DISCUSSION; Systems genetics: the next generation in genetics research?; DISCUSSION
327   $aRegulation of the immune system in metazoan parasite infectionsDISCUSSION; Closing remarks; Contributor Index; Subject Index
330   $aThis book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections.  The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.  Specific 
410  0$aNovartis Foundation symposium ;$v281.
606   $aImmunogenetics$vCongresses
606   $aImmunology$vCongresses
615  0$aImmunogenetics
615  0$aImmunology
676   $a616.0796
712 02$aNovartis Foundation.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9911019098803321
996   $aDecoding the genomic control of immune reactions$94421299
997   $aUNINA