LEADER 03210nam 2200613 a 450 001 9911019093803321 005 20200520144314.0 010 $a9786612122286 010 $a9781282122284 010 $a1282122282 010 $a9780470511411 010 $a0470511419 010 $a9780470511404 010 $a0470511400 035 $a(CKB)1000000000377558 035 $a(EBL)470424 035 $a(OCoLC)609849303 035 $a(SSID)ssj0000354412 035 $a(PQKBManifestationID)11275358 035 $a(PQKBTitleCode)TC0000354412 035 $a(PQKBWorkID)10320245 035 $a(PQKB)10457809 035 $a(MiAaPQ)EBC470424 035 $a(Perlego)2784937 035 $a(EXLCZ)991000000000377558 100 $a19940613d1994 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe lock-and-key principle $ethe state of the art--100 years on /$fedited by Jean-Paul Behr 210 $aChichester [England] ;$aNew York $cWiley$dc1994 215 $a1 online resource (340 p.) 225 1 $aPerspectives in supramolecular chemistry ;$vv. 1 300 $aDescription based upon print version of record. 311 08$a9780471939023 311 08$a0471939021 320 $aIncludes bibliographical references and index. 327 $aThe Lock-and-Key Principle; Contents; Contributors; Preface; 1 Emil Fischer's Lock-and-Key Hypothesis after 100 Years - Towards a Supracellular Chemistry; 2 Molecular Recognition in Biology: Models for Analysis of Protein-Ligand Interactions; 3 New Biocatalysts via Chemical Modification; 4 Oligonucleotides: Superspecific Ligands for Targeting Nucleic Acids and Proteins and Development of Molecular Devices; 5 Macrocycles and Antibodies as Catalysts; 6 Lock-and-Key Processes at Crystalline Interfaces: Relevance to the Spontaneous Generation of Chirality 327 $a7 A Model of the Origin of Life and Perspectives in Supramolecular Engineering8 Perspectives in Supramolecular Chemistry-From the Lock-and-Key Image to the Information Paradigm; Index 330 8 $aPublished 100 years after Emil Fischer first proposed the lock-and-key principle, this volume provides a complete review of the subject to date and offers suggestions for futher research. The major impact of the lock-and-key principle on the chemical, biomedical and materials sciences is discussed by leaders in the field, with chapters dedicated to molecular recognition, nucleic acid and protein chemistry, crystallography and the development of Emil Fischer's initial ideas. The Lock-and-Key Principle is the most up-to-date review of progress in supramolecular chemistry and the lock-and-key principle and will become the essential guide to the past, present and future of this remarkable principle. 410 0$aPerspectives in supramolecular chemistry ;$vv. 1. 606 $aMolecular recognition 615 0$aMolecular recognition. 676 $a574.8/8 701 $aBehr$b Jean-Paul$01838261 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019093803321 996 $aThe lock-and-key principle$94417218 997 $aUNINA