LEADER 02669nam a2200397 i 4500 001 991001528469707536 008 111214s2003 de b 000 0 ger d 020 $a3598112599 (4 vol.) 035 $ab14028761-39ule_inst 040 $aBiblioteca Interfacoltà$bita 082 04$a016.676 245 10$aInternationale Bibliographie zur Papiergeschichte :$bIBP : Berichtszeit: bis einschliesslich Erscheinungsjahr 1996 /$cDie Deutsche Bibliothek, Deutsches Buch- und Schriftmuseum der Deutschen Bücherei Leipzig [Hrsg.] ; berarbeitet von Frieder Schmidt ... [et al.] 260 $aMünchen :$bK.G. Saur,$c2003 300 $a4 v. ;$c25 cm. 505 0 $gBd. 1.:$tAllgemeine Geschichte des Papiers-Territorien und Orte : 00001-09103.$g- LVII, 581 p. 505 0 $gBd. 2.:$tEinzelaspekte des Produktionprozesses, Papiergeschichtsforschung : 09104-20000.$g- P. XVI, 813-2389 505 0 $gBd. 3.:$tPersonenregister, Körperschaftsregister, geographisches Register, Register der Sachbegriffe.$g- P. V, 1207-1811 505 0 $gBd. 4.:$tTitelregister, Konkordanzliste zu WBB, BBB, Leif und Pulsiano.$g- P. V, 1813-2389 650 4$aCarta$xFabbricazione$vBibliografia 650 4$aCarta$xIndustria$vBibliografia 700 1 $aSchmidt, Frieder 710 2 $aDeutsches Buch und Schriftmuseum $eauthor$4http://id.loc.gov/vocabulary/relators/aut$0731878 710 2 $aDeutsche Bibliothek$eauthor$4http://id.loc.gov/vocabulary/relators/aut$0432725 907 $a.b14028761$b02-04-14$c14-12-11 912 $a991001528469707536 945 $aLE002 SB 676 INT$cv. 1$g1$i2002000631039$lle002$op$pE127.25$q-$rn$so $t0$u0$v0$w0$x0$y.i1535992x$z14-12-11 945 $aLE002 SB 676 INT$cv. 2$g1$i2002000631046$lle002$op$pE127.25$q-$rn$so $t0$u0$v0$w0$x0$y.i15359980$z14-12-11 945 $aLE002 SB 676 INT$cv. 3$g1$i2002000631053$lle002$op$pE127.25$q-$rn$so $t0$u0$v0$w0$x0$y.i15359992$z14-12-11 945 $aLE002 SB 676 INT$cv. 4$g1$lle002$op$pE127.25$q-$rn$so $t0$u0$v0$w0$x0$y.i15360234$z14-12-11 945 $aLE002 SB 676 INT$cv. 1$g2$i2002000632371$lle002$op$pE124.50$q-$rn$so $t0$u0$v0$w0$x0$y.i15389741$z12-03-12 945 $aLE002 SB 676 INT$cv. 2$g2$i2002000632388$lle002$op$pE124.50$q-$rn$so $t0$u0$v0$w0$x0$y.i15389765$z12-03-12 945 $aLE002 SB 676 INT$cv. 3$g2$i2002000632395$lle002$op$pE124.50$q-$rn$so $t0$u0$v0$w0$x0$y.i15389789$z12-03-12 945 $aLE002 SB 676 INT$cv. 4$g2$i2002000632401$lle002$op$pE124.50$q-$rn$so $t0$u0$v0$w0$x0$y.i15389790$z12-03-12 996 $aInternationale Bibliographie zur Papiergeschichte$91441973 997 $aUNISALENTO 998 $ale002$b14-12-11$cm$da $e-$fger$gde $h0$i0 LEADER 05396nam 2200685Ia 450 001 9911018973203321 005 20200520144314.0 010 $a9786612331534 010 $a9781282331532 010 $a1282331531 010 $a9780470749043 010 $a0470749040 010 $a9780470749050 010 $a0470749059 035 $a(CKB)1000000000807934 035 $a(EBL)547167 035 $a(OCoLC)501316340 035 $a(SSID)ssj0000301811 035 $a(PQKBManifestationID)11247571 035 $a(PQKBTitleCode)TC0000301811 035 $a(PQKBWorkID)10263324 035 $a(PQKB)10227219 035 $a(MiAaPQ)EBC547167 035 $a(Perlego)2770622 035 $a(EXLCZ)991000000000807934 100 $a20090803d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aLinker strategies in solid-phase organic synthesis /$fedited by Peter J. H Scott 210 $aHoboken, NJ $cWiley$d2009 215 $a1 online resource (707 p.) 300 $aDescription based upon print version of record. 311 08$a9780945090960 311 08$a094509096X 311 08$a9780470511169 311 08$a0470511168 320 $aIncludes bibliographical references and index. 327 $aLinker Strategies In Solid-Phase Organic Synthesis; Contents; Foreword; Preface; List of Contributors; About the Editor; Abbreviations; I INTRODUCTION; 1 General Overview; 1.1 Introduction, background and pivotal discoveries; 1.2 Fundamentals of conducting solid-phase organic chemistry; 1.2.1 Apparatus; 1.2.2 Typical solid supports; 1.2.3 Fluorous supports; 1.2.4 Linker strategies; 1.2.5 Challenges; 1.2.6 Linker groups; 1.3 Concluding comments; 1.4 Personal perspective and testimony: solid-phase Mannich chemistry; References; II TRADITIONAL LINKER UNITS FOR SOLID-PHASE ORGANIC SYNTHESIS 327 $a2 Electrophile Cleavable Linker Units2.1 Introduction; 2.2 Resins for use with electrophilic linkers; 2.3 Electrophile cleavable linkers; 2.3.1 Acid labile linkers; 2.4 Conclusion; References; 3 Nucleophile Cleavable Linker Units; 3.1 Introduction; 3.2 Linker units; 3.3 Nucleophilic labile linker units; 3.3.1 Cleavage by saponification or basic trans-esterification; 3.3.2 Cleavage by aminolysis; 3.3.3 Cleavage by hydrazinolysis; 3.3.4 Cleavage by Hydroxylamines; 3.3.5 Cleavage by other nucleophiles; 3.3.6 Linker cleavage by intramolecular nucleophilic reaction; 3.4 Conclusion; References 327 $a4 Cyclative Cleavage as a Solid-Phase Strategy4.1 Introduction; 4.2 C-N bond formation; 4.2.1 Cyclopeptides and cyclodepsipeptides; 4.2.2 Heterocycles, five-membered ring formation; 4.2.3 Heterocycles, six- and seven-membered ring formation; 4.3 C-O bond formation; 4.4 C-C bond formation; 4.5 Conclusion; References; 5 Photolabile Linker Units; 5.1 Introduction; 5.2 Linkers based on the ortho-nitrobenzyloxy function; 5.3 Linkers based on the ortho-nitrobenzylamino function; 5.4 Linkers based on the ?-substituted ortho-nitrobenzyl group; 5.5 Linkers based on the ortho-nitroveratryl group 327 $a5.6 Linkers based on the phenacyl group5.7 Linkers based on the para-methoxyphenacyl group; 5.8 Linkers based on the benzoin group; 5.9 Linkers based on the pivaloyl group; 5.10 Traceless linkers; 5.11 Other types of photolabile linker units; 5.12 Conclusion; References; 6 Safety-Catch Linker Units; 6.1 Introduction; 6.2 Activation of a carbonyl group by the inductive effect (I-) of an adjacent substituent; 6.2.1 Kenner-type safety-catch linker; 6.2.2 N-boc-activated safety-catch linker; 6.2.3 Sulfide/sulfone safety-catch linker; 6.2.4 Dpr(phoc) safety-catch linker 327 $a6.3 Activation by the mesomeric effect (M-) of the -X-Y=Z moiety adjacent to a carbonyl group6.3.1 Carbonyl activation by oxidative aromatization; 6.3.2 Carbonyl activation by indole ring formation; 6.3.3 Benzyl/phenyl-hydrazide safety-catch linker; 6.3.4 Dehydration activated safety-catch linker; 6.4 Activation by the positive mesomeric effect (M+) of the -X-Y=Z moiety adjacent to a N-acyl or O-alkyl group; 6.4.1 Benzhydryl-based safety-catch linker; 6.4.2 Indole-based safety-catch linker; 6.4.3 Nitrobenzyl alcohol-based safety-catch linker; 6.5 Aromatic SNAr substitution 327 $a6.6 Fragmentation by ?-elimination 330 $aLinker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new 606 $aSolid-phase synthesis 606 $aOrganic compounds$xSynthesis 615 0$aSolid-phase synthesis. 615 0$aOrganic compounds$xSynthesis. 676 $a547.2 701 $aScott$b Peter J. H$0934605 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911018973203321 996 $aLinker strategies in solid-phase organic synthesis$94416874 997 $aUNINA