LEADER 03922nam 2200661Ia 450 001 9911018923203321 005 20200520144314.0 010 $a9786611840488 010 $a9781281840486 010 $a1281840483 010 $a9780470696781 010 $a0470696788 010 $a9780470696798 010 $a0470696796 035 $a(CKB)1000000000555886 035 $a(EBL)366864 035 $a(SSID)ssj0000161580 035 $a(PQKBManifestationID)11155164 035 $a(PQKBTitleCode)TC0000161580 035 $a(PQKBWorkID)10199398 035 $a(PQKB)10441772 035 $a(MiAaPQ)EBC366864 035 $a(OCoLC)264714678 035 $a(Perlego)2760761 035 $a(EXLCZ)991000000000555886 100 $a20080101d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGenetic effects on environmental vulnerability to disease /$fedited by Michael Rutter 210 $aChicester $cWiley-Blackwell (an imprint of John Wiley & Sons Ltd)$d2008 215 $a1 online resource (237 p.) 225 1 $aNovartis Foundation symposium ;$v293 300 $aDescription based upon print version of record. 311 08$a9780470777800 311 08$a047077780X 320 $aIncludes bibliographical references and indexes. 327 $aGenetic effects on environmental vulnerability to disease; Contents; 1: Introduction: whither gene-environment interactions?; 2: Gene-environment interaction: overcoming methodological challenges; 3: Gene-environment interaction and behavioral disorders: a developmental perspective based on endophenotypes; 4: Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory; GENERAL DISCUSSION I; 5: Role of gene-stress interactions in gene-finding studies 327 $a6: Practice and public policy in the era of gene-environment interactions7: Gene-environment interaction and the metabolic syndrome; GENERAL DISCUSSION II; 8: Longitudinal studies of gene-environment interaction in common diseases-good value for money?; 9: Gene-environment interactions in breast cancer; 10: Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections; 11: Gene-environment interactions in environmental lung diseases; GENERAL DISCUSSION III 327 $a12: Gene-environment interaction in complex diseases: asthma as an illustrative case13: Conclusions: taking stock and looking ahead; Glossary; Contributor Index; Subject Index; Color Plate 330 $aMuch research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss:How epidemiological cohort studies can bett 410 0$aNovartis Foundation symposium ;$v293. 606 $aDisease susceptibility$xGenetic aspects$vCongresses 606 $aEnvironmentally induced diseases$xGenetic aspects$vCongresses 615 0$aDisease susceptibility$xGenetic aspects 615 0$aEnvironmentally induced diseases$xGenetic aspects 676 $a616.042 701 $aRutter$b Michael$f1933-$0160572 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911018923203321 996 $aGenetic effects on environmental vulnerability to disease$94416590 997 $aUNINA