LEADER 03478nam 22006495 450 001 9911018651603321 005 20250729130340.0 010 $a9789819679492 024 7 $a10.1007/978-981-96-7949-2 035 $a(CKB)39766931300041 035 $a(MiAaPQ)EBC32249800 035 $a(Au-PeEL)EBL32249800 035 $a(DE-He213)978-981-96-7949-2 035 $a(EXLCZ)9939766931300041 100 $a20250729d2025 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPractical Bioinformatics $eA Laboratory Manual /$fby Sufang Wang, Michael Gribskov 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (143 pages) 311 08$a9789819679485 327 $aChapter 1. Introduction to Bioinformatics -- Chapter 2. Introduction to Antibiotic Resistance -- Chapter 3. Introduction to Evolution and Homology -- Chapter 4. Preparing your sequences -- Chapter 5. Investigating sequence comparison statistics -- Chapter 6. Finding homologous sequences using Blast -- Chapter 7. Finding homologous sequences using UniProt -- Chapter 8. Multiple Sequence Alignment -- Chapter 9. Identifying conserved sequence motifs -- Chapter 10. Building a phylogenetic tree -- Chapter 11. Gene expression analysis in RNA-seq -- Chapter 12. Machine learning methods in RNA-seq. 330 $aThis book is a lab manual which can be integrated with bioinformatics course. The field of bioinformatics is advancing at a remarkable rate. With the development of new analytical techniques that make use of the latest advances in machine learning and data science, today?s biologists are gaining fantastic new insights into the natural world?s most complex systems. This book includes a lab-based manual that can assist students handling large biological data. It aims to help students and researchers understand (1) the importance of horizontal transfer in the spread of antibiotic resistance, and in biology more broadly; (2) how protein and nucleic acid sequences are used to determine phylogenetic trees and the genetic relationship between organisms; (3) how sequence comparisons can be used to infer protein function; and (4) how to analyze high-throughput sequencing data to do gene expression analysis. This book is valuable for researchers, teachers and students, as well as any readers who are interested in bioinformatics. 606 $aGenetics$xResearch 606 $aBiology$xTechnique 606 $aGenetics 606 $aMolecular biology 606 $aBiotechnology 606 $aGenetics Research 606 $aBiological Techniques 606 $aGenetics and Genomics 606 $aMolecular Biology 606 $aBiotechnology 615 0$aGenetics$xResearch. 615 0$aBiology$xTechnique. 615 0$aGenetics. 615 0$aMolecular biology. 615 0$aBiotechnology. 615 14$aGenetics Research. 615 24$aBiological Techniques. 615 24$aGenetics and Genomics. 615 24$aMolecular Biology. 615 24$aBiotechnology. 676 $a616.042072 700 $aWang$b Sufang$01836905 701 $aGribskov$b Michael$01836906 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911018651603321 996 $aPractical Bioinformatics$94415140 997 $aUNINA