LEADER 00952cam0-22003011i-450- 001 990003792360403321 005 20130613082940.0 035 $a000379236 035 $aFED01000379236 035 $a(Aleph)000379236FED01 035 $a000379236 100 $a20030910d1992----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $a<>modernizzazione difficile$el'introduzione dei calcolatori nella gestione di due grandi stabilimenti siderurgici italiani (1969-1974)$fAlberto Baldissera 210 $aTorino$cTirrenia Stampatori$d1992 215 $a179 p.$d24 cm 610 0 $aAziende$aSistemi informativi$aAutomazione 676 $a338.4$v11$zita 700 1$aBaldissera,$bAlberto$0144042 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a990003792360403321 952 $a306.360945 BAL 1$b3896$fBFS 959 $aBFS 996 $aModernizzazione difficile$9506299 997 $aUNINA LEADER 05494nam 22007575 450 001 9911015876103321 005 20250702130314.0 010 $a3-031-91459-7 024 7 $a10.1007/978-3-031-91459-1 035 $a(MiAaPQ)EBC32189556 035 $a(Au-PeEL)EBL32189556 035 $a(CKB)39567939400041 035 $a(OCoLC)1526864011 035 $a(DE-He213)978-3-031-91459-1 035 $a(EXLCZ)9939567939400041 100 $a20250702d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHistone and Non-Histone Reversible Acetylation in Development, Aging and Disease /$fedited by Marta Halasa, Anna Wawruszak 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (646 pages) 225 1 $aResults and Problems in Cell Differentiation,$x1861-0412 ;$v75 311 08$a3-031-91458-9 327 $aPart I. Introduction to Reversible Acetylation and Its Biological Consequences -- Chapter 1. Histone and Non-Histone Reversible Acetylation in Development, Aging and Disease -- Chapter 2. Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer -- Part II. Acetylation of Cytoskeleton-Associated Proteins -- Chapter 3. Acetylation and Deacetylation of Cytoskeleton-Associated Proteins -- Chapter 4. Tubulin Acetylation: A Critical Regulator of Microtubule Function -- Chapter 5. Tubulin Acetylation and the Cellular Mechanosensing and Stress Response -- Part III. Acetylation in Development -- Chapter 6. Reversible Histone Acetylation During Preimplantation Embryo Development in Mammals -- Chapter 7. Epigenetic Echoes: Decoding the Acetylation Journey from Neural Crest to Melanocyte -- Part IV. Acetylation in Physiological and Pathological Processes -- Chapter 8. Impact of Histone Acetyltransferases and His-tone Deacetylases on Adult Brain Myelin Plastici-ty -- Chapter 9. Acetylation in Cardiac Aging: Molecular Mechanism and Therapeutic Approaches -- Chapter 10. Regulatory Roles for SIRT1 in Aging and Immunosenescence -- Chapter 11. Repurposing Histone Deacetylase Inhibitors for Management of Solid Organ Transplant Rejection -- Chapter 12. Acetylation in Viral Infection and Disease -- Chapter 13. Reversible Acetylation of Non-Histone Proteins in Human Cancers -- Chapter 14. Lysine Acetyltransferase 6 Complexes in Neurodevelopmental Disorders and Different Types of Cancer -- Chapter 15. Bromodomain and PHD Finger-Containing Protein 1: From Biological Functions to a Developmental Disorder, Cancer and Therapeutics. 330 $aThis volume explores various aspects of reversible acetylation of histone and non-histone proteins, focusing on their roles in development, ageing and disease progression. It examines the biological consequences of modulating acetylation levels by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Covered are manipulations at multiple levels, from in vitro and in vivo studies to clinical trials and FDA-approved therapies. The book is divided in four parts: Part I provides an overview of post-translational modifications in the context of development, ageing, neurodegenerative and cancer-related diseases. It highlights the role of histone acetylation in higher genome organization and explores the functions of the proteins involved. Part II focuses on the modulation of cytoskeleton-associated proteins through reversible acetylation. It examines how acetylation influences cytoskeletal compartments, thereby regulating cellular structure and function. Part III examines acetylation in the context of development. It describes acetylation as a key regulator of early embryogenesis, influencing chromatin structure and gene expression. Part IV discusses physiological and pathological aspects of histone and non-histone protein acetylation and its modulation by activators and inhibitors. The book is a valuable resource for scientists, clinicians and academic teachers alike. 410 0$aResults and Problems in Cell Differentiation,$x1861-0412 ;$v75 606 $aPost-translational modification 606 $aEpigenetics 606 $aProteins 606 $aCell differentiation 606 $aProteins$xSynthesis 606 $aTumor suppressor proteins 606 $aAntioncogenes 606 $aPost-translational Modifications 606 $aEpigenetics 606 $aProtein Biochemistry 606 $aCell Differentiation 606 $aProtein Synthesis and Translation 606 $aTumour-suppressor Proteins 615 0$aPost-translational modification. 615 0$aEpigenetics. 615 0$aProteins. 615 0$aCell differentiation. 615 0$aProteins$xSynthesis. 615 0$aTumor suppressor proteins. 615 0$aAntioncogenes. 615 14$aPost-translational Modifications. 615 24$aEpigenetics. 615 24$aProtein Biochemistry. 615 24$aCell Differentiation. 615 24$aProtein Synthesis and Translation. 615 24$aTumour-suppressor Proteins. 676 $a572.645 700 $aHalasa$b Marta$01766850 701 $aWawruszak$b Anna$01832391 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911015876103321 996 $aHistone and Non-Histone Reversible Acetylation in Development, Aging and Disease$94406508 997 $aUNINA