LEADER 03558nam 22006375 450 001 9911015686903321 005 20250712130220.0 010 $a9783031953224$b(electronic bk.) 010 $z9783031953217 024 7 $a10.1007/978-3-031-95322-4 035 $a(MiAaPQ)EBC32207543 035 $a(Au-PeEL)EBL32207543 035 $a(CKB)39633457300041 035 $a(DE-He213)978-3-031-95322-4 035 $a(OCoLC)1527858967 035 $a(EXLCZ)9939633457300041 100 $a20250712d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMathematical Modeling of the Healthy and Diseased Lung $eLinking Structure, Biomechanics, and Mechanobiology /$fby Béla Suki, Jason H. T. Bates 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (479 pages) 311 08$aPrint version: Suki, Béla Mathematical Modeling of the Healthy and Diseased Lung Cham : Springer,c2025 9783031953217 327 $aintroduction -- lung anatomy and physiology -- lumped parameter models of lung function -- parenchymal tissue elasticity -- tissue viscoelasticity -- homeostasis and repair -- asthma -- pulmonary fibrosis -- chronic obstructive pulmonary disease -- acute lung injury -- lung defenses -- the aging lung -- what is coming next. 330 $aThe lung is a complex multiscale organ that serves as the primary interface between the environment and the tissues of the body. Homeostatic maintenance of lung function throughout life is essential for health. While failure of lung homeostasis underlies many of the most common chronic diseases that afflict mankind, the precise pathophysiologic mechanisms involved are often unclear. Investigative techniques such as microscopic imaging and atomic force microscopy are providing new insights into lung tissue properties at the micro scale. It nevertheless remains to be seen how this growing body of information can be integrated into a comprehensive picture of the lung. Mathematical and computational modeling has emerged as an essential tool for gaining such a holistic understanding. This book introduces the reader to the art of modeling as a means of linking lung structure to function over multiple length scales from the intracellular level to that of the whole organ, with specific attention given to the pathophysiology of a number of common lung diseases and aging. 606 $aBiomedical engineering 606 $aBiomathematics 606 $aRespiratory organs 606 $aPhysiology 606 $aBioinformatics 606 $aBiomedical Engineering and Bioengineering 606 $aMathematical and Computational Biology 606 $aRespiratory Physiology 606 $aComputational and Systems Biology 615 0$aBiomedical engineering. 615 0$aBiomathematics. 615 0$aRespiratory organs. 615 0$aPhysiology. 615 0$aBioinformatics. 615 14$aBiomedical Engineering and Bioengineering. 615 24$aMathematical and Computational Biology. 615 24$aRespiratory Physiology. 615 24$aComputational and Systems Biology. 676 $a610.28 700 $aSuki$b Béla$01833790 701 $aBates$b Jason H. T$01833791 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9911015686903321 996 $aMathematical Modeling of the Healthy and Diseased Lung$94408739 997 $aUNINA