LEADER 01106nam--2200385---450- 001 990001235870203316 005 20090401145653.0 010 $a0-8039-8959-8 035 $a000123587 035 $aUSA01000123587 035 $a(ALEPH)000123587USA01 035 $a000123587 100 $a20031104d1995----km-y0enga50------ba 101 0 $aeng 102 $aGB 105 $ay---z---001yy 200 1 $aLaw, crime and sexuality$eessays in feminism$fCarol Smart 210 $aLondon [etc.]$cSage$d1995 215 $a250 p.$d23 cm 410 0$12001 454 1 $12001 461 1$1001------$12001 606 0 $aFemminismo$xTeorie e diritto 700 1$aSMART,$bCarol$0226241 801 0$aIT$bsalbc$gISBD 912 $a990001235870203316 951 $aXXVI.1.E 1 (ISP V 725)$b13011 E.C.$cISP V$d00116684 959 $aBK 969 $aGIU 979 $aMARIA$b10$c20031104$lUSA01$h0844 979 $aPATRY$b90$c20040406$lUSA01$h1728 979 $aIANNONE$b90$c20050713$lUSA01$h1254 979 $aRSIAV1$b90$c20090401$lUSA01$h1456 996 $aLaw, crime and sexuality$9987556 997 $aUNISA LEADER 06034nam 22006735 450 001 9911015620703321 005 20250712073522.0 010 $a3-031-91863-0 024 7 $a10.1007/978-3-031-91863-6 035 $a(MiAaPQ)EBC32201090 035 $a(Au-PeEL)EBL32201090 035 $a(CKB)39614958700041 035 $a(OCoLC)1527723880 035 $a(DE-He213)978-3-031-91863-6 035 $a(EXLCZ)9939614958700041 100 $a20250708d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOmics Approaches in Biofilm Research $ePerspectives and Applications /$fedited by Siddhardha Busi, Subhaswaraj Pattnaik, Ram Prasad 205 $a1st ed. 2025. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2025. 215 $a1 online resource (641 pages) 311 08$a3-031-91862-2 327 $aSection I An Introduction to Biofilms and Omics -- Introduction to Microbial biofilms -- Microbial Biofilms and Resistome: Concept and Applications -- Fundamentals and Application of Omics in Microbiology -- Microbiomes and biofilms: Fundamentals and Translational Applications -- Section II Omics in Biofilm Research -- Genomic insights in Biofilm research -- Proteomics and their Applications in Biofilm Research -- Transcriptomics in understanding the Biofilm Dynamics and inhibition -- Metabolomics approaches in understanding the biofilm and its inhibitors -- Metagenomics in understanding the microbial biofilms and Therapeutic Intervention -- Phenomics and microbial biofilms -- Comparative genomics in understanding microbial biofilms -- Lipidomics in understanding microbial biofilms -- Culturomics and biofilms -- Section III Omics as Diagnostic and Therapeutic tools -- Omics in the diagnosis/identification of biofilms -- Omics in Diagnosis and Therapeutics of Polymicrobial biofilms -- Systems biology/Computational systems biology and biofilm -- Synthetic biology and Biofilms -- Omics-based Therapeutics against Biofilm Mechanics. 330 $aThe increased incidence of microorganisms' selective pressure to traditional antibiotics has led to the emergence of multi-drug resistance (MDR) phenomena and has become a global health issue with a catastrophic influence on millions of lives, as well as the global economy. The inherent tendency of pathogenic microorganisms to infer MDR could be attributed to their ability to form recalcitrant biofilm matrices. The biofilm matrix not only advocates chronic nosocomial infections, but also critically provides protection against environmental stress including antibiotic therapies. Biofilm-mediated MDR has posed a serious challenge to human well-being. Henceforth, it is important to understand the pathophysiology of biofilms and the concomitant development of diagnostic & therapeutic modalities to counteract biofilm-mediated chronic infections. The lack of understanding on biofilm biology has a critical negative influence on diagnostic and therapeutic efforts. Therefore, it is imperative to discover the right course of action to understand biofilm mechanics. The advent of Omics-based approaches has provided a holistic realization to understand biofilm ecology with special reference to the pathophysiological interactions of antibiotic-resistant genes, protein-protein interactions, and response-based interactions with therapeutic agents upon infection. The inherent ability of several Omics-based approaches has provided a comprehensive understanding of biofilm dynamics at various levels of organization such as genes, mRNA, proteins, and their regulation. Omics-based tools such as metagenomics, transcriptomics, proteomics, metabolomics, etc. have provided a new horizon to understand and tackle the biofilm-mediated antibiotic resistance. The integrated approach to consider multi-Omics tools (e.g. genomics, transcriptomics, proteomics, lipidomics, metabolomics, etc.) has further improved our understanding of the mechanisms associated with biofilm resistome profile. The applications of transcriptomics, proteomics, and metabolomics profiles of biofilm matrices could provide new dimensions in relation to the characteristic properties of different ARGs, their relative expression profiles, and their metabolic intervention in biofilm mechanics. Also, advanced integrated Phenomics, Lipidomics, and Culturomics approaches could provide novel avenues to understand the diverse range of biofilm phenotypes, their macromolecular reorganization profiles, and molecular tools for identification of microbial species in the complex biofilm microenvironment. Based on the advancement in omics-based tools, ?Omics Approaches in Biofilm Research: Perspectives and Applications? integrates the current knowledge of biofilm microenvironment and innovative strategies to address biofilm mediated drug resistance. This work provides a comprehensive platform to enhance our knowledge, diagnosis and strategies to mitigate biofilms and associated diseases. 606 $aGenomics 606 $aGenetics 606 $aMedical microbiology 606 $aBiology 606 $aMicrobiology 606 $aGenomics 606 $aGenetics and Genomics 606 $aMedical Microbiology 606 $aBiological Sciences 606 $aMicrobiology 615 0$aGenomics. 615 0$aGenetics. 615 0$aMedical microbiology. 615 0$aBiology. 615 0$aMicrobiology. 615 14$aGenomics. 615 24$aGenetics and Genomics. 615 24$aMedical Microbiology. 615 24$aBiological Sciences. 615 24$aMicrobiology. 676 $a572.86 700 $aBusi$b Siddhardha$01832229 701 $aPattnaik$b Subhaswaraj$01832230 701 $aPrasad$b Ram$01781615 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911015620703321 996 $aOmics Approaches in Biofilm Research$94406099 997 $aUNINA