LEADER 04196nam 22006495 450 001 9911010533703321 005 20250612130258.0 010 $a981-9668-31-X 024 7 $a10.1007/978-981-96-6831-1 035 $a(MiAaPQ)EBC32153440 035 $a(Au-PeEL)EBL32153440 035 $a(CKB)39256378400041 035 $a(DE-He213)978-981-96-6831-1 035 $a(OCoLC)1523369944 035 $a(EXLCZ)9939256378400041 100 $a20250612d2025 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDeciphering The Role of Succinate Dehydrogenase in Drug Discovery $eSDH in Drug Discovery /$fedited by Vaishali Manikrao Patil, Dileep Kumar, Satya P. Gupta 205 $a1st ed. 2025. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2025. 215 $a1 online resource (439 pages) 311 08$a981-9668-30-1 327 $aChapter 1. Succinate Dehydrogenase: Structure, Function and Significance -- Chapter 2. The Function of Succinate Dehydrogenase in Maintaining Normal Health -- Chapter 3. Role of Succinate Dehydrogenase in Cellular Respiration -- Chapter 4. Succinate Dehydrogenase: An Important Target in Drug Discovery for Tropical and Neglected Diseases -- Chapter 5. Succinate Dehydrogenase in Mitochondrial Disorders -- Chapter 6. Role of SDH in Cardiovascular Disorders -- Chapter 7. Implication of Succinate Dehydrogenase in Cancer -- Chapter 8. SDH and its Impact on Neurodegenerative Diseases: Autophagy in Neuroinflammation Perspective -- Chapter 9. Neurodegenerative Diseases and Succinate Dehydrogenase: A Therapeutics Avenue for Treatment -- Chapter 10. Fungicidal SDH Inhibitors in Agriculture: Regulation and Future Perspectives -- Chapter 11. Metabolic Disorders and Succinate Dehydrogenase. 330 $aThe book explores various aspects of Succinate Dehydrogenase (SDH) (an enzyme crucial for cellular respiration and energy production) from its assembly and regulation mechanisms to its deficiency and its implications in related disorders. It also encompasses the impact of SDH in obstructive pulmonary disorders, discussing its potential contributions and implications. It explores the design and development of SDH inhibitors as potent agent against fungal infections. It further examines the relationship between SDH mutations and cancer development, linking genetic alterations to tumorigenesis. The book focuses on therapeutic strategies and highlights the role of SDH in managing gastrointestinal tumors, neurodegenerative disorders, and aging-related diseases. It navigates through the challenges and prospects of utilizing SDH as a target for therapeutic interventions. The book also dives into the diagnostic aspects of SDH defects, elucidating their implications and potential diagnosticinvestigations. It serves as a comprehensive guide to unravel SDH's functions, dysfunctions, and therapeutic potentials. By amalgamating diverse areas such as enzymology, genetics, pharmacology, and disease management, this book emerges as an invaluable resource for researchers, clinicians, and students alike. 606 $aPharmacovigilance 606 $aDrug delivery systems 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aPharmacology 606 $aDrug Safety and Pharmacovigilance 606 $aDrug Delivery 606 $aBiomedical Research 606 $aPharmacology 615 0$aPharmacovigilance. 615 0$aDrug delivery systems. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aPharmacology. 615 14$aDrug Safety and Pharmacovigilance. 615 24$aDrug Delivery. 615 24$aBiomedical Research. 615 24$aPharmacology. 676 $a353.998 700 $aPatil$b Vaishali Manikrao$01828543 701 $aKumar$b Dileep$01426826 701 $aGupta$b Satya P$0944589 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911010533703321 996 $aDeciphering the Role of Succinate Dehydrogenase in Drug Discovery$94397460 997 $aUNINA LEADER 03760oam 22005293 450 001 9910583356903321 005 20250204110448.0 010 $a0-12-809842-2 010 $a0-12-809841-4 035 $a(CKB)4100000000646805 035 $a(MiFhGG)9780128098424 035 $a(FRCYB88849511)88849511 035 $a(BIP)55712151 035 $a(FR-PaCSA)88849511 035 $a(MiAaPQ)EBC5085057 035 $a(EXLCZ)994100000000646805 100 $a20210525d2017 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aFundamentals of Toxicologic Pathology 205 $a3rd ed. 210 1$aSaint Louis :$cElsevier Science & Technology,$d2017. 210 4$dİ2018. 215 $a1 online resource (885 pages) 327 $aPreface -- 1. An Overview of Toxicologic Pathology -- 2. Biochemical and Molecular Basis of Toxicity -- 3. Pharmacokinetics and Toxicokinetics -- 4. Principles of Pharmacodynamics and Toxicodynamics -- 5. Morphologic Manifestations of Toxic Cell Injury -- 6. Carcinogenesis: Manifestation and Mechanisms -- 7. Design of Studies and Risk Management in Toxicologic Pathology: Addressing Risks in Product Discovery and Development -- 8. Liver and Gall Bladder -- 9. Cardiovascular System -- 10. Skeletal Muscle System -- 11. Urinary System -- 12. Immune System -- 13. Hematopoietic System -- 14. Respiratory System -- 15. Digestive System -- 16. Exocrine Pancreas -- 17. Male Reproductive System -- 18. Female Reproductive System -- 19. The Mammary Gland -- 20. Endocrine System -- 21. Nervous System -- 22. Special Senses -- 23. Bone and Joints -- 24. The Integumentary System -- 25. Embryo, Fetus, and Placenta -- Index. 330 $aFundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development.The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.- Presents revised and updated information for each chapter on systems- Contains expanded sections on applied toxicologic pathology- Includes the essential information necessary to understand toxicologic pathology in an accessible language 606 $aToxicology$xmethods 606 $aPoisoning$xpathology 606 $aPoisoning$xphysiopathology 615 12$aToxicology$xmethods. 615 22$aPoisoning$xpathology. 615 22$aPoisoning$xphysiopathology. 676 $a615.9 700 $aWallig$b Matthew A$01739563 701 $aBolon$b Brad$0970645 701 $aHaschek$b Wanda M$01739564 701 $aRousseaux$b Colin G$01739565 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583356903321 996 $aFundamentals of Toxicologic Pathology$94163612 997 $aUNINA